By
Sampson Onwuka
The Chapter was destined to be written and the final solution begins from where we started….
There is something about the Medical Institutions and the
Act of medical discoveries that can plunge an entire world of information into
some abyss until perhaps redemption. All the breakthroughs in science and
technology need not be rehearsed as a consequence of these long years of
experiment and studies, leading to disasters of all types and sometimes with
some degree of consequence. One man whose theory concerning the problems of
perpetual error and why institutions carry on with these mistakes is Joseph
Greenberg in his dissertations about language and human dispersion theory,
theories well evident by the Luigi Cavalli-Sforza. Mistakes can be conceived by
any number of institutions and can be transferred from one form to another and
until a breakthrough; it survives some of the assumptions in business and
elsewhere. The advent of HIV at least in the least in the last 35 years is no
different from this kind of problem, especially those of Polio which has given
us all the headache known to us.
That a thing and perhaps a sickness such as paralyses from
Polio eluded the frontiers of sciences for at least 40 years in spite of the
breakthrough by the Karl Landsteiner on A, B, O on the bone marrow and the
brilliance of a certain Jewish immigrant by name Simon Flexner who for his sake
and for the need of medical research that they developed the Rockefeller
Institute in New York.
These men including those took umbrage under his leadership, (1) Herald Cox (2) Max Theiler (3) Isabel Morgan (4) Thomas Francis (5) Tom Rivers (6) Peter Olitsky (7) Albert Sabin, names very familiar with us in Virology and the culture, and like in many open sources these are champions of medicine for many years in vaccination and early attempts stem cell research. The book that throws some light on the history of these few including the familiar Max Theiler who succeeded in growing a Virus in the brain of mouse is called Polio; An American Story, by David M. Oshinsky (05), we should be able to quote from this book, at least in gainsaying on some of the assumptions about the connection between Polio and HIV, where the author made some medical blunders no more than the ones that Merck made about the unknown dynamics of the human immune system.
These men including those took umbrage under his leadership, (1) Herald Cox (2) Max Theiler (3) Isabel Morgan (4) Thomas Francis (5) Tom Rivers (6) Peter Olitsky (7) Albert Sabin, names very familiar with us in Virology and the culture, and like in many open sources these are champions of medicine for many years in vaccination and early attempts stem cell research. The book that throws some light on the history of these few including the familiar Max Theiler who succeeded in growing a Virus in the brain of mouse is called Polio; An American Story, by David M. Oshinsky (05), we should be able to quote from this book, at least in gainsaying on some of the assumptions about the connection between Polio and HIV, where the author made some medical blunders no more than the ones that Merck made about the unknown dynamics of the human immune system.
But in Oshinky’s ‘Polio’ story we are privy to his citations
describing an important figure in fight of Polio by name Karl Landsteiner that
“At his Laboratory in Vienna, Landsteiner produced an emulsion from the Spinal
cord of a boy who just died of Polio. He passed the liquid through a porcelain
filter, injected the contents into the stomach of two rhesus monkeys, and
waited to observe the result. It didn’t take long; the monkeys proved to be
wonderfully susceptible hosts. Both succumbed to Polio, their spinal cords
showing much the same damage that had occurred in the little boy.
The Polio virus had been isolated.” The process of extracting a virus would in future be that complicated but they follow the same process, yet the intentions behind rendering the piece in spite of the Polio is taint the discourse with the bone marrow incident regarding the treatment of immune deficiency syndrome that much effort has been put in to help the victims of the AIDS whose bodies are racked by the virus by chemotherapy in removing much of the bloods in the spleen and bone marrow of the affected areas or areas of interest, and using a foreign entity and bone marrow try to restore the blood of the patient in a process that is similar to cancer treatment yet they get worse and worse.
The point that HIV is at least for now a blood borne Virus does not
The Polio virus had been isolated.” The process of extracting a virus would in future be that complicated but they follow the same process, yet the intentions behind rendering the piece in spite of the Polio is taint the discourse with the bone marrow incident regarding the treatment of immune deficiency syndrome that much effort has been put in to help the victims of the AIDS whose bodies are racked by the virus by chemotherapy in removing much of the bloods in the spleen and bone marrow of the affected areas or areas of interest, and using a foreign entity and bone marrow try to restore the blood of the patient in a process that is similar to cancer treatment yet they get worse and worse.
The point that HIV is at least for now a blood borne Virus does not
If the virus is fed through the mouth the victim hardly
suffers any special injuries and any specific inductive injuries but when the
Virus is fed through the nose, the reactions were very fatal. In fact the mode
of infection which are so believed as the same and similar to Tuberculosis
which infected people through the nose and breathing, cursed severe reaction in
the body of the victims particularly the monkeys, may have given some reason
that the mode of penetration of the virus was similar to other agents of the
body.
David Oshinsky writes that “No one found a way to block
poliovirus from entering the body or to neutralize it with drugs or chemicals
once it got inside” For many years the conception that the nose was how the
virus entered the body proved frustrating to scientist and in the image of
Simon Flexner who help to carry out major reforms in virology, there was hardly
anyone to challenge the basic assumptions.
There was something else, apparently the reason why the mouth feeding of the virus did not convey any particular kind of adaptive meaning, is that the monkey used for these experiment is called Rhesus monkey. Its ability to mount immune response depended on many things, in part for the silaic acids which are contained in the body and are presence in the nose and nasal cavity, exfoliates its existence and as someone theorized, many people did not know why we couldn’t stop the virus from entering the body. It would seem that it was only through the nose that such penetration of the body was possible.
There was something else, apparently the reason why the mouth feeding of the virus did not convey any particular kind of adaptive meaning, is that the monkey used for these experiment is called Rhesus monkey. Its ability to mount immune response depended on many things, in part for the silaic acids which are contained in the body and are presence in the nose and nasal cavity, exfoliates its existence and as someone theorized, many people did not know why we couldn’t stop the virus from entering the body. It would seem that it was only through the nose that such penetration of the body was possible.
The story on how it was discovered that other primates
reacted differently to the virus when fed from the mouth is not clear, but the
opposition of Flexner to the use of these primates proved that it was a
well-known fact or suspected as such that a particularly kind of monkey acted
differently when the virus is fed through the mouth. The rest were victims of
the same thing. For that reason, the understanding that the route of the virus
was from the alimentary canal and not the nose or at least more than nose,
proved a damage to Flexner’s theories and became a point of rally for all
scientist. This new knowledge is so critical to further enhance the experiment
on Polio viruses that it led many scientists to shift their attention from
monkeys to chimpanzees.
Oshinsky put it kindly that “if Polio virus entered through
the mouth and worked its way down the digestive tract, then it must travel
through the blood before entering the central nervous system. If so, a vaccine
designed to raise anti-body levels in the bloodstream would be able to
neutralize the virus before serious damage was done.”
From this development, they were able after almost forty
years of the studies on Polio virus to now learn how the virus develops and
what makes it work and why the virus became a hit for the rest of the
scientific America. At least Scientists were now able to focus at (early
infection) and the blood stream was the place. In the words of John Paul, “It
meant that small amount of virus which invaded the blood could probably be
overcome by relatively small amounts of circulating anti-body, and by this
means could be blocked from gaining access to the central nervous system….At
one fell swoop, the problem of immunizing man had been rendered easier than was
expected.”
Among the first investigators to look at the virus in
previous and neglected blood samples was a certain Dorothy Horstmann, who was a
member of Yale crack Polio Unit team of invested much of her time in looking at
blood of the victims that came into the hospital from the 1943. A basic line
should include David Bodian and his group; she was not the first or the only
one that looked at the blood of the victims that were infected by the Polio
virus. And the blood became very central to the point of demonstrating from the
stored blood of nine year old, that unless the virus was not in the system and
in the body already, there was no way of knowing unless she got sick. That it
was only on this account did any change take place in the body at all, that as
soon the blood realized that it had a disruption in its system, proteins and
folded inwards and then the attack on the nervous system which is primary to
the virus.
If fed through the mouth the virus could invade all the
stomach and reach down the body where it profligates, but majority of time and
according to several practices which are done, the virus hardly makes it into
the blood stream in large amount when induced through the mouth of some monkeys
and ended up creating paralyses leaving antibodies which has neutralized the
virus. The whooping size of his academics raised the tempo of suspicion towards
Apes, Chimpanzees, and Monkeys as probable origins of the Virus which
eventually came in with their mutations in human and hence nearly justified the
all kinds of experiments in Congo. I must confess I have only casually flip
through the books and do not intend on writing on what clearly obvious from his
missive that the general academic consensus favors a Spillover from Monkeys and
Chimpanzee into Human beings.
Philip Alcabes (2010) Dread book that attempts to consider
what the early CDC workers attempted to achieve with HIV and how some of the
jokes about HIV did not shy from the social stigma of those who were called
freaks or in the 60’s bums, who suffered all kinds of malfunction in the body
and were essentially housed elsewhere till perhaps redemption which sometimes
arrived too late. If it is not impossible to locate this item elsewhere is
because of alternate historical account of outbreaks in City wide location,
point to breakthroughs that gave medicine a new and profound meaning.
In his chronicle on HIV he pointed to an early date made by CDC released in September 1982, that “Homosexuals or bi-sexual makes – 75%, intravenous drug abuser with no history of homosexual activity – 13%, Haitians with neither a history of homosexuality or intravenous drug abuse – 6%, persons with hemophilia A with no other risk factors – 0.3%, and persons in none of the other groups – 5%.” Whereas anyone could get the virus he argues, HIV was simply the most dreaded thing partly for the fact that there was no cures at the time, but largely for the social stigma that was associated with it. Many of the Black and Hispanic in New York did not see it as very present and dangerous virus capable of infecting black as well others, and they loathed the virus as a white-man disease.
In his chronicle on HIV he pointed to an early date made by CDC released in September 1982, that “Homosexuals or bi-sexual makes – 75%, intravenous drug abuser with no history of homosexual activity – 13%, Haitians with neither a history of homosexuality or intravenous drug abuse – 6%, persons with hemophilia A with no other risk factors – 0.3%, and persons in none of the other groups – 5%.” Whereas anyone could get the virus he argues, HIV was simply the most dreaded thing partly for the fact that there was no cures at the time, but largely for the social stigma that was associated with it. Many of the Black and Hispanic in New York did not see it as very present and dangerous virus capable of infecting black as well others, and they loathed the virus as a white-man disease.
But before long, it was gradually shown that the virus began
as a series of carefully planned conquest over the host immune system, and
after a decade of the virus of the human it degenerates into something else.
For if Blacks were gradually gaining up to others despite
being one of the smallest groups of minority in New York in terms of new cases
on HIV, it was due to the problems of information and reaction, which do not
add to anything useful.
For Asians and Africans, they were largely hung over on the
transfer of the new virus emanating from Gay Communities in New York to other
parts of New York and elsewhere, and since they loathed these communities; they
are easily vulnerable to the viruses.
Although New York in times past may have entertained the arrival of
diseases and other infectious disorder, it has lead the fights against
dangerous diseases, against Polio and Influenza, against diseases; both
airborne and waterborne. The City is hive of visitors with long term view of
the City and travelers for other reasons and immigrant population since the
18th hundred has continued to sprawl till very recent days.
New York downtown has no particular architectural, the
immigrant populations; Irish, Italians, Jews, Africans, Caribbean, North and
Central America, and other income capable brackets were primarily concerned
with their own survival. Although the immigration continued in New York by
Europeans, it helped to form some of the assumptions about new diseases and
epidemics, to a point that it can be said that studies about the early diseases
in New York in the last 100 years or so were mostly derived from reaction to
outbreaks such as Chicken Pox (Varicella), Pertussis (Whooping Cough),
Pneumococcus, Hepatitis A, Hepatitis B, Rotavirus, Influenza, Meningococcal and
some variety of human papillomavirus. In a sense some of the assumptions about
these diseases made outsiders temporary targets for reasons of their own.
The Polio virus was one of those outbreaks where a strain
from African monkeys was very necessary in understanding the pathology of Polio
which Flexner believed was generated from stomach to the body or through
digestive tract – in essence it was ingested. Many of the experiments at the
very beginning had to with mouth feeding of some of the creatures and primates
– especially monkeys were fed through the mouth with strains of Polio virus and
the end was not to the interest of the scientist. The main point is not the
process of profligate Polio virus but on why it was necessary to ingest the
various from the beginning and why the issue of blood pathogen proved a
different and difficult point to redress. Look at it differently, when it
became very clear that the Polio passed through several processes and
especially the blood, the science committee was more than ready to handle the
Polio mellitus once and for all.
Secondly, if the mentioned virus-ridden diseases and
conditions, especially Influenza and Spanish Flu for instance of the 20th century
A.D, were considered from purely medical and biological point of view, they
show patterns of infection and host-DNA which alters the destruction of the
infection process of the virus, some produce fever others with the same viral
infection may give similar but different infection in the body. The immigration
population who make it to New York where left to places such as Randall’s
Island, New York, a place which as the repository for those dead or dying. Of
course they naturally remain quarantined saving for instances of Polio and
viral strain of its culture.
The modernity of New York as now and then appears on the
world map and its visible schools of medicine was not always the case, for at
least we can set our eyes on the formidable FDR days, whose efforts as Governor
of New York and eventually president proved a watermark for the attitude of the
public to issues of health. It would not mean that Harlem River drive heading
the F.D.R was named after for political reasons, but the combating of Polio by
forces affiliated with his office such Bob O’Connor makes the faithful date of
CDC recent as they provide the necessary tools towards the growth in health we
have seen over the years. But needs be mentioned that a lot list of all the
breakthroughs of sciences in the United States and in the world did not arrive
by idle conjecture, did not arrive by efforts of any one group such those for
instance at Rockefeller Institute which has fielded and trained more competent
and decisive virologist in the last formidable century, more than nearly all
institutions anywhere in the world.
Perhaps the Pasteur Institute of Paris or other Schools of
interest in Massachusetts; Harvard, etc., which though perform its function
along the elite schools of the country, cannot in itself expel the contribution
by other schools either directly or indirectly influenced by Rockefeller
Institute in the last century.
This will not mean that schools such as City College of New
York with as many Nobel Prize winners as Yale is to be taken away, it shows
however that the merit of open culture and attitude to this merit widens on the
even the smallest avenue of possibility that what works in one area, may not
apply in other cases. It will be useful
to point that the Cold Spring Laboratories in Long Island maintained an open
culture and relevancy of attitude to science from the days of its founding by
Watson and Company to nearly all combating of new virus which CDC is
particularly known for. That will add to the assumptions that the failures over
the years to deliver on HIV may be due to the fact that it was believed to be
disseminated through deviant sexuality and the encouraging the scorn that it
was created by God. But if half of what learnt over the years and at least in
the opening heroic search for cure at the beginning was never replaced or
transferred from one community to another, we may have in my view – purely in
my view – put a final end to the Virus.
While it is easy for me to accept that giant steps in
Medicine has failed in generating final solutions for HIV, it serves then as
well now as an example for what may have transpired between Polio Virus and the
arrival of the scientist who ended the whole sage. In areas I succeeded might
clearly interest you with the fact that I spent 2 years studying Harvard
Medicine for fun of it. And in the last returning decade and a half have spent
hours of a given day on History, Anthropology, and generally studies human
genetics. Majority of these studies show it’s relativity to HIV and the cure
for immune deficiency syndrome prove a lengthy stay for reasons of their own,
to a point that some of the conclusion vary in its results and the end point
was a question of some understanding about viruses and its evolution. This
aspect of our understanding of biology and chemistry is very important given
the very reason why vaccinations seem to have failed.
Barely a year ago, the argument about the SVO40 virus
supposedly from Chimpanzee and the Polio virus seem to have stagnated between
Chimpanzees and human immunogenic viruses, which may have resulted the strain
from Polio considered a leading item to HIV. But this argument in all its forms
had to be dealt with, perhaps decisively given the basic premise of HIV
infections and its pathology. Put it differently, there is no connection
between Polio Viruses and HIV, and there is no link between immunogenic viruses
which infect primates and humans saving the issues of the patterns of infection
and the chief cause of the agents. The example about the slow viruses and
oncogenic viruses are especially important largely for leading but misleading
line of reason about HIV and the very knowledge of viruses and immune
deficiency syndrome.
Looking backwards to some of the stories from Bronx and from
parts of White Plains, New York in the early 90’s, there is hardly anyone who
knows what the virus was all about and what its problems anywhere. It was known
to be deadly, known to remain dormant for a long time, to be conversant with
Homosexuals and with illicit drug users, where they speculated that sharing
needles was very dangerous because of the dangers of blood contamination.
Special classes are taken to handle blood and the secrets keep so tightly about
victims that even some of the workers were placed on a need to basis. On a
special basis as well, there are reference to Russia and the events of Cold
viruses, including period of long epizootic and Moritz Kaposi (Russia)
associated with description of what eventually considered Sarcoma, and pox
related virus sickness.
We have reached perhaps another threshold in the studies of
Biology and we are looking at the period in Medicine when the theory of the
Human Immune Deficiency Syndrome can be finally given an official
obituary. In keeping to themes of 2014
August 12th, and the injunctions justifying great periods in the annals of
world history, we can begin from May 15, 2015, to attempt a public analyses of
the theories involving HIV and how it can finally be set aside for all times.
It may not be the case when there are various cases on HIV stories that need
not be repeated but do generate as much enthusiasm as new breakthroughs in
Biology. Drawn from the piece from last year, we can recall that the emphasis
on Polio Virus was the author’s systematic strategy in analyzing some of the
gaps and deficiencies which bar the final solutions and answer for
Interleukin-2 virus and HIV. To the extent that this author classified HIV as a
blood cancer was no new article of faith, it was driven perhaps by lateral
arguments on Lentivirus and the slow Visna viruses some of which are gradually
due to the origins of the strains. One of the flim-flam from Robert Gallo is
the attempt at correlating Cancer or Oncogenic viruses and HIV, that is
Oncogenic and Lentiviruses such Visna develop gradually inside the cell of the
recipient.
In a forward by Bill
Clinton to the book written by - San Francisco, November 26, 2012 - to a new book on HIV/AIDS anthology, he
asked the same questioned we have maintained over the years, “ that when the
history of HIV/AIDS is at last written, what will the final chapter look like?”
And former Secretary of State Hilary Clinton maintained that “…the goal of an
AIDS-free generation may be ambitious, but it is possible with the knowledge
and interventions we have right now. And that is something we’ve never been
able to say without qualification before. Imagine what the world will look like
when we succeed.”
Visionaries write the Final Chapter One AIDS – The First
In an essay on a new book by Neil Giuliano presented by
Andrew Hattori on the issue of AIDS in a
new and recent book, that when the final chapter on AIDS is written, what will
it look like? This provocative question is posed to 15 authors—political
leaders, researchers, activists, and pioneers—in How AIDS Ends, a special
anthology produced by San Francisco AIDS Foundation featuring a foreword from
President Bill Clinton.
“Each contributor to this anthology has been deeply touched
by AIDS and each of them, including myself, is equally committed to realizing
that joyful day when AIDS is part of our past, not our future,” said Neil
Giuliano, CEO of San Francisco AIDS Foundation. “How AIDS Ends captures this
forward-thinking spirit and reminds us that when it comes to the fight against
HIV/AIDS, there is no shortage of hope.”
Contributors include Timothy Brown, Jeanne White Ginder,
Cleve Jones, Barbara Lee, Mark Dybul, Paul Farmer, Robert Gallo, Mervyn
Silverman, Diane Havlir, Scott Wiener, LZ Granderson, Hank Plante, Eduardo Xol,
and Neil Giuliano. They share their unique perspectives on the HIV/AIDS
epidemic, their visions for how it ends, and who they will remember when that
day comes.
“When we finally defeat this disease—hallelujah!,” writes
Jeanne White Ginder. “I think on that day, I will feel that Ryan did not die in
vain.”
“Now is the time to write a new chapter in the triumph of
hope over despair and love over fear and hate—a new tale of the wonder of the
human spirit,” writes Mark Dybul, the newly appointed executive director of the
Global Fund to Fight AIDS, Tuberculosis and Malaria.
“When the AIDS epidemic ends—when we have a vaccine to
prevent new infections, and everyone who has HIV can manage it with drug
therapy—what a joy, what a relief,” writes Dr. Robert Gallo, one of the
co-discoverers of HIV. How AIDS Ends is published as a digital book and is
available through Amazon and other online retailers for 99 cents. All proceeds
from the book will be used to support the free HIV prevention and care services
of San Francisco AIDS Foundation that improve the health of thousands of people
every year.
--------------------------------------------------------------------------------------------------------------------------------
Some of the assumption can be reduced to the schools of
interest that make a difference between and
Dogma for HIV
It is translated
from one person to another through blood and sexual contact showing signs of
Rash, Kaposi virus – Michael Gottlieb,
It does not
transfer from one primate to another – Sampson Onwuka
It is a lentivirus
– it kills slowly and separate itself from Oncogenic viruses because of the
Interleukin 2 – Luc Montaigne
It is an oncogenic
virus and show patterns conceivable close to a strain of cancer which seem
parallel to a strain of monkey virus from Zaire - Robert Gallo
It is a blood
Cancer comparable to the – Sampson Onwuka
It refrains from
DNA of the host and does not have personal DNA and it has two pieces of RNA –
CD4 and Retro-virus – David Baltimore
It is Thymus
depended – a general dogma and has a tendency to use E. Coli and Streptococcus
Its formative
origins may have started differently – perhaps male to male – primary
productive isolation – Sampson Onwuka
Vaccination is
Contagious – and probably unsafe – Prophage and Age of Bacteria – Sampson
Onwuka
People do not
necessarily die from HIV, they die from opportunistic infection – general dogma
HIV virus is not
the only immune deficiency syndrome, auto-immune failures can be induced by
drugs and
Use of AZT and
other drugs may be useful in decreasing the Course of the Virus and not the
rest…
Put it clearly, we must necessary understand that the
process and complication of thymus as a sugar complex ; the CD4, the
penetration of the human immune system by locally manufactured foreign virus
(HIV) and the gradual evolution of a prophage whose life retains a DNA from
previous reproductive process gives us the impression of Immune Deficiency that
is determined by the ability of existing DNA and genetic substance – Cytosine,
Guanine, Adenine and Thymine, and here we can easily lift from Genetics Home Reference
the following definition, that “DNA bases pair up with each other, A with T and
C with G, to form units called base pairs. Each base is also attached to a
sugar molecule and a phosphate molecule. Together, a base, sugar, and phosphate
are called a nucleotide.”
So together, a base, sugar, and phosphate define nucleotide,
and from well-rehearsed arguments from last year, the finally parted ways role
of Thymus is rebuilding human DNA, that the complex breakdown and regeneration
of life was considered a well distributed responsibility among the primary
chemicals but like Bromide-5-Methylation, the process of adapting the body to
new realities is something achieved by Thymus or CD4s. The author also
identified the particular kind of sugar dissolving bacteria that can considered
– part and central to these process – especially the introduction Avery Oswald,
Alfred and Martha Chase well received experiment, perhaps with reason and
succinctly by French scientist Andrew Lwdolf, Jacque Monod and Maurice Francoise,
especially Jacque Monod and the emphasis on E.Coli.
If suggest that the title of this essay and in fact one of
the more important essays of our generation should be 'Kicking the Ass of AIDS'
but we shall open up on this topic by citing that Human beings have always
found themselves challenged by all plaques since the beginning of time, that
the great advantage of our time is the new techniques and new machines are
being used, and are to investigate on this virus and are sometime successful in
discovering of the agents responsible for these new virus and infection.
The title of this essay and in fact one of the more
important essays of our generation should be 'Kicking the Ass of AIDS' but we
shall open up on this topic by citing that Human beings have always found
themselves challenged by all plaques and have always had the sciences to defeat
them but as victim of our personal institutions and unyielding institutions in
understanding the errors associated with long held Theories, some of these
plaques and diseases or infection such as HIV tend give more headache that its
needed and then the cure is usually decades away instead on a few years. I
shall mention that going forward; the cure for HIV/AIDS can be reduced to a few
years.
I should be childish to indicate that based on half my
knowledge on the subject, I can master and kick the ass of this virus in months
of uninterrupted lab work. Some may at the sheer optimism of someone without a
doctorate in Medicine or Biology. While it is easy for me to accept that these
giants in Medicine failed in areas I succeeded, I might clearly interest you
with the fact that I spent 2 years studying Harvard Medicine for fun of it. And
in the last returning decade and half have spent hours of a given day on
History, Anthropology, and generally studies human genetics. Looking backwards
to some of the stories from Bronx and from parts of White Plains, New York in
the early 90’s, there is hardly anyone who knows what the virus was all about
and what its problem anywhere.
It was known to be deadly, known to remain dormant for a
long time, to be conversant with Homosexuals and with illicit drug users, where
they speculated that sharing needles was very dangerous because of the dangers
of blood contamination. Special classes are taken to handle blood and there was
secret keep so tightly about victims that even some of the workers were placed
on a need to basis. One of the books that recollect some of the stories in the
Bronx and New York, is the book by Philip Alcabes (2010) Dread, considering the
what the early CDC workers attempted to achieve with HIV and how some of the
jokes about HIV did not shy from the social stigma of those who were called
freaks or in the 60’s bums, who suffered all kinds of malfunction in the body
and were essentially housed elsewhere.
In his chronicle on HIV he pointed to an early date made by
CDC released in September 1982, that “Homosexuals or bi-sexual makes – 75%,
intravenous drug abuser with no history of homosexual activity – 13%, Haitians
with neither a history of homosexuality or intravenous drug abuse – 6%, persons
with hemophilia A with no other risk factors – 0.3%, and persons in none of the
other groups – 5%.” Whereas anyone could get the virus he argues, it was simply
the most dreaded thing partly for the fact that there was no cures at the time,
but largely for the social stigma that was associated with it. Many of the
Black and Hispanic in New York did not seem it a very present and dangerous
virus capable of infecting black as well they loathed the virus as a white-man
diseases who like in the ass.
But before long, it was gradually shown that the virus began
a series of carefully planned conquest and after a decade on the virus, it
Blacks were gradually gaining up to others despite being one of the smallest
groups of minority in New York. For Asians and African, they were largely hung
over on the transamination of the viruses through Gay Communities in New York,
since they loathed these communities; they are easily vulnerable to the
viruses. Although New York in times past
may have entertained the arrival of diseases and other infectious disorder, it
is has lead the fights against dangerous diseases, against Polio and Influenza,
against diseases; both airborne and waterborne which some travelers and
immigrants brought to New York, in which several places such as Randall’s
Island, New York, served as the repository for those dead or dying, remain the
quarantine when there is instances of such cold and influenza in all classes of
respect and decorum.
The modernity of New York as now and then appears on the
world map and its visible schools of medicine where not always the case, for at
least we can set our eyes on the formidable FDR days, whose efforts as Governor
of New York and eventually president proved a watermark for the attitude of the
public to issues of health. It would not mean that the anointing of Harlem
River drive heading the F.D.R was named after for political reasons, but the
combating of Polio by forces affiliated with his office such Bob O’Connor makes
the faithful date of CDC recent as they provide the necessary tools towards the
growth in health we have seen over the years. But needs be mentioned that a lot
list of all the breakthroughs of sciences in the United States and in the world
did not arrive by idle conjecture, did not arrive by efforts of any one group
such those for instance at Rockefeller Institute which has fielded and trained
more competent and decisive virologist in the last formidable century, more
than nearly all institutions anywhere in the world.
Perhaps the Pasteur Institute of Paris or other Schools of
interest in Massachusetts; Harvard, etc, which though perform its function
along the elite schools of the country, cannot in itself expel the contribution
by other schools either directly or indirectly influenced by Rockefeller
Institute in the last century. This will not mean that schools such as City
College of New York with as many Nobel Prize winners as Yale is to be taken
away, it shows however that the merit of open culture and attitude to this
merit widens on the even the smallest avenue of possibility that what works in
one area, may not apply in other cases.
I
t will be useful to point that the Cold Spring Laboratories
in Long Island maintained an open culture and relevancy of attitude to science
from the days of its founding by Watson and Company to nearly all combating of
new virus which CDC is particularly known for. That will add to the assumptions
that the failures over the years to deliver on HIV may have been due to the
fact that it was disseminated through the stigma of deviant sexuality
encouraging the scorn that it was created by God. But if half of what learnt
over the years and at least in the opening heroic search for cure at the
beginning was never replaced or transferred from one community to another, we
may have in my view – purely in my view – put a final end to the Virus. The
Chapter was destined to written and the final solution begins from where we
started….
One of the things I was privy to is the suicidal behavior
and tendency of the victims leading me to understand why in the end, preventing
the expansion of HIV was both dependent on the conscious decisions of the diagnosed and the attention given to
the lifestyle on those either not sure or those with redoubtable status. The
later may account for obvious cases of HIV transmission some of whom understand
the implication of their lifestyles but would rather play ignorant to a HIV
than face the emotional injury and social stigma associated with recently
diagnosed. It is not enough to claim that a socials stigma for HIV is not as
strong as may have been suggested, it is however a state of mind that welcomes
the cure is not yet available that leads to doomsday psychology. Majority of
the emphasis on this virus and patient is created in such a way as to suggest
that it is the sexual activity of some group of Americans, for instance the so
called Gay or Lesbian (?) or the African Americans whose nature is prone early
healthy sexual life, are those who are major players in the spread of the
Virus.
The other such as the Latino and Hispanic community has also
noticed a spike in the new cases, largely for the attempt at testing for the
Virus than other means. But in the end, the last two groups receive the highest
blame for the spread of HIV, whereas, anybody can infect others or infected by
others. These stereotypes, particularly the problems of expertise of the field,
Doctors or Nurses or Health Care experts, loathe observations by nearly anyone
without a badge of certificate or honor. As such only those who caught the
Virus and those with close family member with the diagnosed status that are
interested in the learning about HIV with a degree of interest. The rest of us
are incurable expat on opinions and diagnostic made available by those in
field, but by condition of more direct investigation of the Patients and their
drugs, we are able to see through the understandable but proud-ridden
closed-off of medical institutions; CDC (Center for Disease Control) and
private medically experts each seeking in their own ways to find the cure for
HIV – one of the Viruses that can lead to Immune Deficiency. The reasons why
these organizations react with disdain to such things are many, including a
possibility of Abuse and use of a medical terms that need explicating to
novices, but it seems that the terms and conditions are no replacement for the
Virus itself and why more can be done towards a better understanding of the
Virus, why it attacks or attaches itself to a CD4 host and why in the end, the
Virus overpowers the immune system.
The few stories which we remember from the early years of
the virus includes one concerning the Kaposi Sacoma which appear in the skin of
mostly HIV position homosexual male. The Candidiasis appears in blood groups of
mostly Hemophiliac and people with chronic cases of blood thinning and
Pneumonia. The transfer of blood played so significant and blood management
also played a serious hand in deciding early reaction to HIV and from downtown
New York was a man by Michael Rosenberg who dies in 1994 from blood and HIV
complications not before founding the Hemophilia/HIV peer Association, which
sort at least in New York to monitor blood distribution and donation through
the State.
AN outbreak of contaminated Blood plasma in Tokyo a decade
earlier threw a lot of light of how the confusion between Hemophiliacs, Sickle
Cell, and Blood Anemic patient peered off with cases of compromised immunity
sped through blood donation and government officials and how they affected
people with HIV in New York and many other parts of the country. Whereas the
issue of blood transfusion and Plasma donation has been partly common in New
York due to a peculiar kind of immigrant entering through its harbor, it never
amounted to grave and deciding consequences until there were obvious problem of
pox developing in the blood of victims of a supposed newly linked virus.
One of the earliest warnings on the blood transfusion came
from Susie Quintana who was believed to have contracted AIDS through the process,
but the litigations did not arrive on time for her settlement which eventually
reached 8 million dollars. The other early warning on blood transfusion came
through Corey Dubin who like many people in the 60’s, 70’s and 80’s in New York
and Los Angeles receive blood transfusion as Hemophiliacs contracted the immune
deficiency after receiving Factor VIII with ‘experimental clothing factor’ as a
child, had struggled with his immunity and had reasons to believe that the poor
regulation of the Internal Society of Blood Transfusion and the use of gamma
globulin in restraining Hepatitis considered harmless by scientist.
These stroke of different shades provide insights into the
history of blood pathology and the effective means to fight them which may or
may not have provided the background to the studies in Pneumonia, but most
perhaps prepared to the landing of the Gallo team based in new York, who
successfully isolated the virus for Leukemia and what they collectively call
Retrovidirae, beginning with HLTV virus group that oncogenic but has not linked
to any particular form of cancer beside the blood associated pneumonia.
Robert Gallo team did find it compellingly to relapse into
the studies on the latest vaccine used at the height of Polio, to the point
that some of the conclusion regarding the deep Cameroun boundaries and the
Congo where the HIV is mainly to be located seem to have started with his
clearing on this topic. The corrections are long since observed that other
parts of world has presence of what seem to be similar to HIV, but the
foundation explicating of why it was Africa or any region in the world has not
really surfaced among scientist. It is tradition that several diseases not
familiar with man is perhaps deeply in severe locations of the world, as such
the moving from these creatures to human could have resulted from recent
contacts and may have triggered dormant bacteria or viruses which cause 75%
(three quarters) of the Cold virus in human beings, much of with simply lay
dormant only on compromised immunity essentially take over the body.
The discoveries of the French team lead by Montagnier are no
more than what they are, exception based on the virus that used as a prototype,
to the point that a connection to the earlier years of those whose Kaposi
Sacoma in New York could not be treated and who deficient in the defense
network, points to deviant sexual behaviors, to some point separated from those
in Los Angeles, who though had the same virus evident in their body, where also
showing some depression in the system and the presence of candidiasis including
breathing problems. It is therefore not an immaculate conception that the
breakdown in the body of those diagnosed with Pneumocystis – itself a fungus
with some of its element are copious bacteria without walls usually classified
as Mycobacteria loosely for they do in epigenetic methyl based complexes, than
the cold they could create, perform the same havoc when tripped like
staphylococcus and streptococcus which perform separate disorder in the body
but primarily infection leads to cold, either in the first primary phase or
when contracted through a secondary agent.
The imperial weight of the changing dynamics of the human
cold driven viruses and bacteria is why there is new need for vaccination
against influenza every year. The cold with its new pollen dust simply trips
the dormant and friendly viruses in the body leading to dysfunction of the type
I and II alpha globulin defense system in names of mucous and in the names of
microfibers in the intestines where lymphocytes depressed histones mount a
first attack – albeit sneezing or allergic reaction.
Irwin Sherman (2007) we cite that “HIV has in its genetic
blueprint 10, 000, nucleic acid bases (adenine, uridine, cytosine, and guanine,
or A, U, C, and G); That is about 1/100, 000, the number of nucleic acid bases
we have in our each of our cells. The genes of HIV consist of a long string or
strand of nucleic acid bases built into this strand, in a coded form, is all
the information needed for the manufacture of its proteins. Each gene has a
particular sequence of bases in the RNA. The genetic code is a triplet codes
that is, three nucleic acid bases (called a triplet) code for one amino
acid.” This important for similar
reasons that a Peter Deusberg’s on HIV assessment considered, that for him,
Deusberg ignored the fact spread of HIV could occur through regional lymph
nodes.
Whereas certain others who tried a life-form of polio
vaccination may be accused on genetically and inadvertently triggering a new
Virus altogether are not that not guilty, they, like the those who used a dead
virus are innocent in spite of the acceptance that a certain SIV 40 strain of
monkeys and perhaps Chimpanzees were found in the vaccine that this like even
S1V and SV1 or SIV2 does not affect human beings or make them sick. The primary
challenges of Peter Deusberg to Luc Montagnier and Robert Gallo is that the
virus called HIV could not have been new, may have an original virus existing
in the human body or familiar with human body till the social habits of drugs
particularly familiar with Homo-sexual began to take a hit on their immune
system. The Arrest house of the lungs raised for Verghese points to this very
fact that various diseases are kept under arrest by the body and y the actions
of the Chromosome 8 until the defense system is broken to the point that the
body can no longer synthesis, split and condition these viruses.
The Cold Viruses like the Bacteria in certain regular
circumstances is likely a breeding gamut for cold environment and unlike
Bacteria who explode in more hot climate and moist environment and which can
also die when extensive exposed to heat, we find that the creatures that are
mainly associated with these viruses are usefully discovered in these areas.
One of these cold bearing viruses common in Russia and further up is the water
fowls. One of the greatest associations of the water fowls to cold is the
arrival of epidemic such as zoonosis like we find in Russia, where a certain
form of death occurs rapidly among the water creatures such as fowls, and like
we find in other places with enormous categories of dead fowls, a shift in
environmental conditions may give some indications of a peculiar arrival of a
any new form of Cold Virus such as the Avian for instance.
We may have noticed that the rest of the general physiology
of the body as we observe in nature is to be interpreted as the product of what
lies within the body. That we have
arrived from the history of the older times to the age of enlightenment with
various understanding on how the body works and why it differs from one to
another, that it inherits certain diseases from the host (parents) during the
meiotic, that the system in of itself can be damaged and can lead temporary and
permanent injuries in the body. The body
in of itself can regulate itself, thrives on its self- sufficiency (Claude
Bernard), that the Microbes described in ancient books could be seen on
microscope (Leuwenhoek), that they harm the body and could not be called one
form (Henle), that these could also be studied and separated according to the
disease they create and the infection in the body (Koch), that these viruses
are old and region specialized (Darwin, Mendel), there is a Germ plasma
(Pasteur), there is a mortal soma (Weismann), that these two must repeat in
such a way that the rate of reproduction could be matched by the body, can be
achieved through the mastering the Germ and the Plasma leading to the products
of proto-type such as Penicillin (Jennings).
There other foundations of Biology and medicine that are
important, used in part by Peter Deusberg that viruses capable of causing
epidemic should be new viruses – set in order of Koch – where the theory was
also placed in different in terms of (Farr) on the veracity of a New
Virus. While we may indicate that the
whole statement raised by these experts are true, they are true to the extent
that the body could easily adjust to changes in the body and in the environment
if and when the exposure to the system do no prove fatal. It is taken that
these viruses capable of destroying the body in slow or speed motive are doing
so for many reasons including that the body and CD4 cannot keep up.
However there is no going that HIV is an infectious disease
in keeping to Deusberg and in Order of Farrs - HIV viruses do not meet the
criteria for infection, adding that the virus is considered a retrovirus
essentially to the careers of Gallo, Baltimore, and Montaigne, whereas
retrovirus and the reverse transcription of RNA to DNA and DNA to RNA through
an enzyme, means that HIV could have been the reasons for AIDS as according to
Deusberg, but in all, shows that the total damage that the body can sustain is
sufficient to satisfy its healing and its cure so long the exposure does not
directly and indirectly kill the system composed mainly of active cells. For that,
there are chances that the bi-product of the human body which are physical and
which separate us from each other, can traces of the returning few months and
carry viruses and bacteria that the body pushing out.
In practice, the total amount viruses and diseases that can
exist the body or at least circulating within a given community may be
considered relatively comparative to the amount of human activity in this
period, may remain within the comparative ration until unusual activity such as
industrial expansion or disease bearing animals not familiar with an
environment and ecosystem interferes, then there is event horizon.
From the levels of the DNA philosophy and the ordering
knowledge of the Sciences available to us today, there is no question that it
is a mistake to view without reason or even without books, that a certain virus
could possibly exist somewhere in the Universe that do not have the basic DNA
familiar to mammals, that do not have a basic structure that can understood and
tampered, and can be used in experimental isolation of several key minerals in
the body or in the body of the animals which they came from.
For instance, a Histone and Histamines are minerals based
Enzymes that can be extracted from Birds and Calf as well. Histones are found
in the Calf Thymus and in Spleen and Liver of bovine mammals, but in all, they
can also be found in the Spermatozoa of these Bovine creatures. Between the
Thymus of Calf and its Spermatozoa is one product that are found the in the
mucosa intestine, will not propelled a connection between Thymus and
Spermatozoa, ready-make the answer the secret of mammalian existence in the
final product or Spermatozoa.
Vaccination…
We may have noticed that the rest of the general physiology
of the body as we observe in nature is to be interpreted as the product of what
lies within the body. That we have
arrived from the history of the older times to the age of enlightenment with
various understanding on how the body works and why it differs from one to
another, that it inherits certain diseases from the host (parents) during the
meiotic, that the system in of itself can be damaged and can lead temporary and
permanent injuries in the body.
The body in of itself can regulate itself, thrives on its
self- sufficiency (Claude Bernard), that the Microbes described in ancient
books could be seen on microscope (Leuwenhoek), that they harm the body and
could not be called one form (Henle), that these could also be studied and
separated according to the disease they create and the infection in the body
(Koch), that these viruses are old and region specialized (Darwin, Mendel),
there is a Germ plasma (Pasteur), there is a mortal soma (Weismann), that these
two must repeat in such a way that the rate of reproduction could be matched by
the body, can be achieved through the mastering the Germ and the Plasma leading
to the products of proto-type such as Penicillin (Fleming).
Alexander Fleming after his long explicating on the limiting
factor of bacteria at the perhaps phage level, invented penicillin as a
‘limiting factor’ for staphylococcus, or as they coined, ‘growth inhibition
effect of penicillin on Staphylococcus’. Fleming was associated with what is
now called the Antibiotics which has set precedence in the light of many
discoveries since 1929. In Germany in 1932 discovered that a lumen based
‘Prontosil is effective against Streptococcus infections’ which though not
necessarily linked at a time to measles (proved a difficult treatment in
Europe. It is this well tout idea of limiting growth or the profligate of
Bacteria, either artificially or naturally as in the case between Candidiasis
and Streptococcus Pneumonia, that in relative construct of the balance of some
of the assumption in the body, there is a shift from seem like Dormant genetic
of acquired Chromosomal inheritance and the bacteria that lies beneath it.
We may point to this import and decisive years in the
medicine as instrumental in understanding how bacteria work, especially a phage
level, to a point that a mass production of Penicillin in United States by
Howard Florey was successfully established in the United States…..It needs be
mentioned for historical reasons that the impact of isolating these limiting
growth factors, inspired the works of later medical experts including Alfred
Hershey and Delbruck, all of whom may be considered right in the light of some
of the exercising impact of bacteria or viruses induced diseases or conditions
such as those of Hemoglobin.
Wendell Stanley isolated the virus that causes tobacco
mosaic diseases, which was completely shown to be Fungus family that also
perpetuates its existence.
Gradually the number grow in the interest of those looking
to isolate from the pact, that in 1948 Selman Waksman in the United States was
the first to ‘isolate streptomycin from Streptomyces griseus’ which also
provided that a means of inoculation and vaccine and eventually the advent of
Poliomyelitis during the World War I and World War II, that makes its clear,
that the greatest difficulty that the account of Salk and Sabin over the
invention of Polio vaccine had to be settled outside academic exercises. For if
we are to compare some of the changes that has taken place…..On account of
Jonas Salk and the backing from supporter such as Basil O’Connor and following
the breakthroughs in understanding the DNA and the double helix after two of
the greatest scientist of the last century, James Watson and Francis Crick,
then came other invention after Enders’ theory, that Albert Sabin opposed and
put to be the dividing line for the age of the discoveries. Ender’s theories
are a full re-interpretation of the accounts of the effects of the…..
Reading from the Verghese book, (1994), we discover the
strange reasons why there is a failure in tying some of the loose ends of the
study of the Virus. He mentions for instance that “…pneumocystis had a long
history before AIDS made it a household word. Epidemics of Pneumocystis swept
through Europe in the 1940’s. They occurred primarily in premature infants in
orphanages, in the setting of overcrowding and malnutrition.” The author discussing this statement made overt
connection between the depletion of one’s defense system and the activity of
some external agent. That not all immune deficiencies are caused by
Pneumocystis, that however Europe after the wars, discovered itself confounded
by the cases of ‘immune compromising conditions’ and one of such was this virus
and the other was also Leukemia which required long list of blood donors.
The author goes on to raise the question on the nature of
the Virus and why as late at the 1990’s its pathology still eluded the most
accomplished medical scientist. He asked “how are we to view this organism? As
an invader from outside or an as opportunist from within?,” and he attempted to
answer the question by reference a case of infecting a rat with
pneumocystis pneumonia, that ‘all you to
do is give the rat cortisone, - a potent suppressor of immune system – and the
rate then spontaneously develops pneumocystis infection.’ That in comparison to
the injections on the rate with Staphylococci, the rat is able to mount immune
response. His conclusion and the conclusion of his colleague named ‘Betty’ from
the Rat experiment is that “…Pneumocystis is present in low numbers in the lung
at all times….The constant vigilance of the immune system keeps it in check.
Immune suppression by steroids…AIDS results in unchecked multiplication of this
organism.”
While the theories of the presence of pneumocystis (that is
if and when contracted) in the lungs usually reverts to create pneumonia may be true to a certain
degree, it is perhaps composed without respect to other experiments performed
by medical doctors, that one, linked the presence of SIV from primates to
humans, that both of the conclusion from Verghese and the general theory
concerning suppressed Pneumonia virus in the body, fails to have incorporated
the more basic science that the SIV linked to Polio Virus were not always found
in the lungs of the primate. Would not mean that the lungs are safety houses
for arrested viruses, would probably compel the secondary argument that the
reversal of some virus conditioned by the actions of Chromosome 8, which is RNA
Chromosomes houses or control about 95 percent of human genes which the body
does not really need.
Simply put, the relationship between the Chromosome 8 and
the functions of the human immune system is so well linked that it is possible
to suggest that the immune deficiency which may result from any number of
causality is within the limits of the functions of Amino Acids, particularly
Cytosine, Adenine, Guanine and Thymine, whose structure is not variously
changeable, but adapts to the presence of foreign elements by replacing either
of major Acids in its Nitrogenous bases.
For if we take Verghese argument seriously that shortfalls
in immune system can revert the problems of control to access the body leading
to a damage of information systems as in this case Pneumonia from Pneumocystis,
we push the argument that nearly all viruses arrested or conditioned for the
benefit of the body may become by occlusion, very dangerous variously or
bacteria as the case would be. In this clear that a perpetual breakdown of
human immune defense may lead all kinds of conditions, but to the degree that a
virus – either manufactured by the other and from a primary agent – would
permanently weaken the body, suggest sometime systemic, and more that buries
the special status or privilege of Pneumocystis.
Here we consider the point Verghese made about the presence
of the virus in Europe in the 1940’s and try to explicate the departure from
the various histories associated with such a virus to a reason that it started
from Africa, by indicating that the formal intent of many medical students at
the early stages of the virus was not to discover the cure but perform to
discover what could cure the virus. In the opening accounts of the doctor’s
books, he mentions for instance that he “…had arrived in America as a rookie
doctor in 1980. At about the same time, HIV, the virus that causes AIDS landed
in the port cities of United States; New York, San Francisco and Los Angeles.”
The Virus, he said, “…arrived from Africa (perhaps via Haiti) carried in the
bloodstream of one or more unsuspecting people who had then passed it on by
sharing needles or through sexual intercourse.” The particular summary is quite
difficult to conceive of, especially from the elemental view of an interest
possessed with the origins of a named virus Pneumocystis which from his reading
existed in Europe.
The conundrum from that statement is of epic proportion for
at least it harbors the good and damn right bad about the veracity of HIV. If
it is said to have been discovered very early as a marked by Pneumocystis which
the earlier cases in Los Angeles cited and in conjunction with instances of
Sarcoma in some already known Gay Couples in New York, his statement proclaims with
the depths of ignorance involved in scientific quest for a cold virus, or it
mirrors the prison in which the medical scientist and their institutional
errors were by concerns or early theories which was rooted in smallest of
experiments at Ely Lilly were laid to draw a misleading complex about the
Virus. That a transfer from Africa shield as wells manes the resources
available in Science in 80’s for making advances that left much of the world
forlornly.
The danger of blood borne hepatitis and “plasma mills” as
described in detailed by J. Garrot Allen.
The other early warning on blood transfusion came through Corey Dubin
who like many people in the 60’s, 70’s and 80’s in New York and Los Angeles
receive blood transfusion as Hemophiliacs contracted the immune deficiency
after receiving Factor VIII with ‘experimental clothing factor’ as a child, had
struggled with his immunity and had reasons to believe that the poor regulation
of the Internal Society of Blood Transfusion and the use of gamma globulin in
restraining Hepatitis considered harmless by scientist.
These stroke of different shades provide insights into the
history of blood pathology and the effective means to fight them which may or
may not have provided the background to the studies in Pneumonia, but most
perhaps prepared the landing for Gallo team based in New York, who successfully
isolated the virus for Leukemia and what they now collectively call
Retrovidirae. Beginning with HLTV virus
group that oncogenic but has not linked to any particular form of cancer beside
the blood associated pneumonia.
That for instance, “The lysogenic and non-lysogenic strains
of Streptococcus pyogenes are far from harmless, since they are one of the two
major causes of human infections and of pus formation in wounds. However, when
lysogenic strains of S. pyogenes undergo virus-induced lysogenic conversion,
they start to produce the toxin that causes scarlet fever….” That “After a few
or a few thousand passages from generation to generation of lysogenic bacteria,
the long-dormant lysogenic prophages suddenly revert to virulence and start
acting like normal virus genomes. They take command of the chemical and
metabolic systems of the bacteria cells. Inside of a few minutes, the cells
start to produce hundreds of mature phage particles, enough to tear themselves
apart.” This discovery was made the
Fredrick Loeffer who worked on the Corynebacterium Diphtheria isolated by
Edward Klebs and was considered a germ for diphtheria by Robert Koch, but was
rejected or placed under suspicion by international medical community as bacteria
that was not very destructive and was no less than what it was a common
bacteria similar to streptococcus found in the throat…
But Loeffer eventually demonstrated that the bacteria
isolated by Kleb was the agent that caused Diphtheria which did not have the
toxin, however this bacteria was meant to remain dormant and friendly until its
DNA structure was essentially altered by some other events in the body or in
the circumstances relating to the human conditions. This adds to distemper the
suggestion of Duesberg and the Laboratory experiment frequented but mentioned
in this case by Abraham Verghese, that some bacteria can remain dormant for
long time until triggered by the presence of Cortison or other drug that
attached the CD4s in the human system.
………………………………………….
In this case, the point that “…increasing evidence points to
hypersensitivity reactions of the immune system to antigens or the candida
surfaces or the metabolic products of the organism…” will attract some new
explicating since the latest ELISA test and the earliest ELISA test as based on
the reactionary tendencies of the CD4. It does not mean that ability of any
Fungus to evade the body relapses into the penetration of the body by the cell
and the fungus, including its pathogenicity; how its penetrates and what
regions, that it makes to the blood streams (Se….?) later argues for a late
onset which from its earliest beginning did not begin through the blood stream.
Assuming the fungus-like structure or the bacteria with the
hints of fungus such as Candidiasis – although mainly if not exclusive from
plants hence a construct for fungus – penetrates the walls of the body by
action and help of histamine that naturally help the penetration of the walls
of the cells since like CD4 they operate on the surface, would mean that the
IgA through IgE gradually mount reaction to this fungus in such a way to
suggest that structure travel first from IgG less environment since this
particular kind of antibody only surfaces in the life on a child after the
first 6 months within which Candidiasis generally penetrate the child’s system
failing to fully show its given the hundreds of other bacteria that reach the
child as well.
HIV is a virus that invades the body is an infection largely
for what it does over time to it, that it can weaken the immune system is a
fault that is not exactly of its own making. It is therefore necessary to
incorporate some of the assumption in the piece by Deusberg that the some
bacteria do in fact remain dormant, and here confirmed by the authors of the
Magic Shot, these viral bacteria affect passing a process of chromosomal
exchange, end up producing viruses that are familiar with a system. In this
case, we invoke the thesis in the earlier our earlier composition that perhaps
second premise, that the Virus may have started its journey as something other
than virus but gradually ended as dangerous to the system due to changes that
gradually take place when the CD4 is said to be at its lowest end.
In some measure, the role of viruses entering the body
either through the mouth which is usually the causeway of most live virus into
the body are naturally arrested by Alpha Globulin IgG, which mount the initial
defense in the body and along the respiratory tract and into the gut of the
intestine and mucosa, and they are usually found in the tears, in mucus, and in
the intestine where they confront the new arriving viruses, but then the body’s
lymphocytes and lymph cells produce proteins called Igs, Igm, that gradually
react to these new arrivals and are mostly found in the blood, then it
moves….the last of these immune-globins are the biggest and these are the
arresting houses of some of the bacteria that die naturally or forever
perpetuated in the system through the control of the cells.
List …….
From the above instances, we can conclude that some of the
changes that arrive at the Candidiasis or the earliest immune related to
‘candida albicans’ and sometimes by other species such as C. Trophicalis which
are naturally supposed to be harmless may become virulent affecting several
parts of the body, invading the cells, including some of the mast proteins and
basophils, creating conditions of osteomyelitis (muscle-skeletal disorder),
skin rashes (some of which are comparable to Sarcoma), whacks the central nervous system
(meningitis),…..“Because Candida are normal members of the body’s microflora,
their presence on mucous membranes is tolerated by immune system, and the
inflammatory reaction induced by hypersensitivity response becomes a chronic
condition. This reaction may remain local, at the site of dense colonization by
the organisms, or became systematic and affect any organ system in the body.”
(Joneja, Bielory, Understanding Allergy). Allergic reaction to be sure is triggered
by many things in the body, but when there are instances of chronic candidiasis
caused by Yeast-like fungus usually remain dormant from birth but gradually and
eventually reappears when there is a less presence of the cells that control
them, for instance in the case a competing bacteria all of which attack people
from the earliest years of the child conception and delivery to about 6 months
after delivery. It is the presence of some of these bacteria based complexes in
the body, many of which reach the newly born from respiratory tract that
compose the transfer and translation of these bacteria into highly favorable
and systematic protection that the body needed.
The Arrest house of the lungs raised from Verghese points to
this very fact that various diseases are kept under arrest by the body and y
the actions of the Chromosome 8 until the defense system is broken to the point
that the body can no longer synthesis, split and condition these viruses. This example in the way they cited in this
account do not fly in the face of other accounts or in the presence of the
claims made by Verghese, regarding the introduction of Cortison into the body
whereas it enables the body to fight off cold of some types, it leaves the body
essentially vulnerable to increase in bacteria and fungus once dormant in the
body. This results from the depression of the immune system by the immunogenic,
unlike the type I, type II, type III and type IV, defense mechanism we regard
the structure of the cell and its ability to manufacture immune-globin and its
response to foreign antigens are reactions that are derived from the presence
of the lymphocytes’ protein and the reaction time necessary for the body to
overcome.
Using the example
from Joneja, Bielory, the ability of Candidiasis to make this comeback in the
body is due in this case to combination through types of defenses the body
could mount. That in the case of the fungus-like structure of candidiasis it
has the ability to withstand the first round of the attacks by the body,
usually in the intestines and the rectum, for here the body’s first lines of
defenses are in the mucosal where histamines that help to embellish the
chromosome and the actions of the CD4 in the body, play a hide and seek game
with what looks like Mucous in the body, hence
Candida which ‘…are normal members of the body’s micro-flora…on mucous
membranes is tolerated by immune system, and the inflammatory reaction induced
by hypersensitivity response becomes a chronic condition.’
There are from earliest entrance into the body of the child
part of its mechanism, to the point that their reaction to the system is based
on human less the body tolerates them, depends on the presence of competing
bacteria and foreign antigen which Chromosome 5 is very good for – at least
towards conditioning their own complexes hence composing the degree of
tolerance by the Chromosome 8 and the human immune system. These exposure that
a child has a young age is perhaps good and bad, would not have mattered where
it not for the tripping in the defense system, some on account of the cold
virus and the other, on account of the presence of other chemical element which
the body naturally produces. Brightly speaking, even a sugar complex may create
serious immunogenic havoc when in excess composition in the body, and when the
body can manufacture.
Here we paint a quick brush stroke on the early papers on
this virus; New England Journal of Medicine published in 1981 with title
“Pneumocystis’ Carinii Pneumonia and Mucosal Candidiasis in previously Healthy
Homosexual Men – Evidence of a New Acquired Cellular Immunodeficiency.” This
caption more than explains the convulsion involved with the new virus, it
throws light on what they consider to be the more evident ….with the virus,
that it is above all ‘...a new acquired cellular immunodeficiency’, means that
other forms of immunodeficiency were not unknown and not unfamiliar with
Sciences, that it means to suggest that was exclusively common among Gay at the
time, admits the problems of demonstrating that among the early cases were
Haitian immigrants. However the weight of the material in Haiti was no nearly
as profound as it became some time later, that it means to suggest that Haiti
got a fair shake for allegedly harboring the killer virus, also throws some
light on what early theories could really do in the later studies on a virus
and its pathology.
We might cite some examples that experiments between human
and primates were performed extensively in Africa in the 80’s, with added
expectation that SIV passed from Primates to Humans, that blood samples from
monkeys and Chimpanzees were missed SIV and injected in human bodies, and the
results which many early enthusiast hope for similar failed. SIV from these
primates injected in human and conditions over a period of six months, did not
material a zoonotic of any familiar kind, including the hints of HIV. We point
that when blood contaminated with HIV were injected into primates that mounted
immune responses. To a point that among the earlier experiments on the Zoonotic
pathology of the virus, is the aspect of injecting the bloods of primates
infected with a bacteria such as plasmodium from any number of mosquitoes and
the blood introduced into human beings, there was no side effects saving for
the interference with foreign heme from primates. There other human fever
causing bacteria and viruses that were tainted by the pro-phage and introduced
in vivo to primates, vice versa, and both parties mounted immune
responses. From these early experiments
that failure of understanding the permeation of one’s immune system by a single
virus pre-occupied the minds of even the most adept of all genetic engineers
and molecular biologists.
We may be sure that the story of that vaccination do not
have to fly in the face of Hippocrates (Greece) ‘father of medicine’, 1527
‘Jacques de Bothencourt of (France) that gave the name venereal to sexually
transmitted diseases. We are here as we were there, that in 1530 Girolamo
Fracastoro (Italy) gave a new name to Syphilis which was in 1530 a not well
known virus that purified human flesh particularly their prized private parts.
Syphilis and even Gonorrhea were latter day names to well-known sexually
transmitted diseases whose names became a house hold in the analytic measures
of Louis Pasteur, is small which was no well conquered until a medical
breakthrough of vaccination.
Then as now, the medical societies has rolled its sleeves on
some of the most daring of challenges, one of which is Small Cox that grim
ripper that bested the young lives of many abled Europeans. We are funny to
mention that the Africans and the Asians with their long and estimable memoriam
of the styles and systems involved in dealing with small pox, through
variolation, it won’t be funny going by the decided nature of Edward Jenner of
England and experimentations that the vaccination against small pox was
possible because of him. Now as well then, the motivation is seeking a cure of
a virus from the novelty of existing pre-dead or a parent or host of a life of
a cell, by re-introducing the elements of the causing agents into a healthy
body to placate the profligate viral cells, the body manages to arrest the
development of foreign and enemy cells by incorporating it into its system the
living verdure of the intruder. The only difference is when by experiment and
experience would it be fitting to expose the body to such baby viruses or adult
viruses, to form a kind of defense mechanism which is best understood by what
we call immunity.
What is Immunity some
may ask? It is the ability of the body to mount immune responses to foreign and
threatening influences by processing the DNA of the living creature and almost
like food delivered to its system. It incorporates the cells of the foreign
anti-gene into its life structure. This
is a well-known fact and it’s the subject of many experts interested in curation,
especially the new methods of gene therapy and blood and tissue transplant that
has offered some light at some end of unknown medial challenges. This is in
fact true, so true that if it was not, a vaccine for HIV would have grace our
markets long before now. It is here more than anywhere can we spy the final
triumphs over HIV, since as I have argued and no one perhaps known to us and
myself, that HIV is in fact a cell by itself mounting in of itself its own
immune responses to human envelope cell based system. How come? The question is
also the answer, for how can anyone prove otherwise than re-interpret my own
thesis in candid light of the male factor, which is not necessarily overstated
or requiring early cases of HIV virus to show for it, which in this case,
requires an understanding of biology and genetic studies to gradually enter the
dragon here.
All and near medical
breakthroughs since the advent of man, all victory over all kinds of all kinds
of disease- causing agents follow this replacement pathway, either emasculating
the progress of the virus through capturing its viral DNA and capsid as in
Bacteria, or by injecting a deleterious chemical into the body artificially
reduce the infection and sickness. All of these can be enhanced through the
physical and nutritional support to the effective system. All medicine,
especially diseases related, it’s really a means to an ends, not to be confused
with Watson’s ‘like to like’ or ‘likes’ to the opposite which was obviously
wrong in interpreting the DNA structure, rather the human body like all levels
of cell structure evolve through replacement process, and due to its
evolutionary opulence to new life it attracts foreign cells which are sometimes
detrimental. This is evolution almost as if to suggest that immunologic of
human body is the root of its evolutionary pathway.
Louis Pasteur in France understood fermentation and ended up
doing a great service is isolating the bacteria for Rabies….sometime in 1885.
But in the United States, almost to a miraculous endearment, there was a
discovery and a breakthrough in sexually transmitted diseases by Phillippe
Ricord (U.S) separated gonorrhea from Syphilis. Albert Neisser (Germany)
Isolated the organism that causes gonorrhea (1879), 1880; Charles Laveran (France)
described Protozoan parasite of malaria, and 1882, Elie Metchnikoff (Russia)
was able to separate the Phagocytes in the White Blood cells…Anti-bodies called
immunologic E binds to mast cells or binding of IgE to mast when complete, the
body releases a massive dose, of histamines….bacteria can inhibit the binding
of IgE to the mast cells, - and histamines are not released and therefore no
allergic reaction.
What a shame that
Vaccination is based on old medical turf gives the impression that we know to
expect from viruses. But it seems that the initial runoff success from the time
of Onesimus from Senegal, U.S Army and the George Washington’s Orders for all
soldiers to be vaccinated against small pox, some advances have been achieved
in vaccination, but the chief instrument of the exercise which is variolation
has not really changed. Edward Jenner credited with the discovery of
vaccination added some measure of medical practice that is not new or started
by Jenner. But being able to describe the process in such a way that it became
a standard practice earned him a place in the history of medicine. Using the
virus to wage defense against a virus is not exactly complicated a process, but
the process is the root of some of the greatest breakthroughs in Medicine,
especially in ho some bacteria and some viruses are able to empty their capsule
while attaching their DNA to the host. It was not solved until the age of
crystallography and the event of Watson and Crick.
This evolution requires a better treatment, but to a point
that the influenza of the World War I and the attachment of some young doctors
in administrating the flu shots and what they experienced with respect to the
delivery of the injection, presented the first major problems of vaccination
with respect to Alexander J and his Penicillin. However the events where
over-shadowed by the Polio virus which defied nearly a half century of medicine
in US, suppressing the discoveries of Griffith and his ‘transforming principle’
which Oswald Avery took over. We may
consider these periods as quite important in vaccination given the proof that
it was the baby versions of the virus which as nothing but RNA that are
attached to human DNA is such a way that the structure of the Virus from the
Mature version would no longer be required.
Not until World War
II were they new demands on the delivery for the best approach to vaccination
which was tackled by Rockefeller Institute in New York and by Thomas Francis
(?). It is interesting that one his assistant is a doctor that will become
central to the dissent over Polio, and this was James Salk. For nearly the last
100 years, the whole Dogma of vaccination is simply used and improved from
older systems of first identifying the disease, then the causal agent for instance
the Germ and then isolating the agents which Louis Pasteur and August Weisman
clearly showed was bacteria. Isolating the soma from the Germ and isolating the
bacteria allowed scientist to replicate its process and re-introduce it to the
system. This was classic Pasteur and had been used with effective respect to
the fermentation very successfully. The whole course of the various cures and
vaccination or inoculation – using life viruses – of nearly all competent
diseases and severe cases of hormonal breakdown has been met and repaired by
Scientist until HIV. But this tug in the arms on the Practice is no without
history and explicating it is in Darwin and some versions of evolution history.
Using Victoria A. Harden ‘(2012) historical prĂ©cis on the
origins and pathology of HIV , “…humoral immunity is made up of immune system
cells called B cells (because they originated in the bone marrow.) When a B
cell encounters an antigen, a molecule or substance that is foreign to the body
(such as invading virus), it engulfs the invader to another immune-system
cell, the helper T cell. The helper T
Cell secret chemicals called lymphokines that enable the B cell to multiply
into plasma cells that secrete specific antibodies, proteins used by the immune
system to identify and neutralize foreign molecules that lock onto the invader.
The helper T cells also trigger the development of memory cells B cells, which
“remember” that particular invader’s immunological signature.”…….”Cellular
immunity is the second arm of the immune system….T Cells (named because they
are processes through the thymus gland as they mature) are also activated when
macrophages “present” an antigen to them
It is not the first time that speculation has led scientist
all over the world into unknown areas of interest. At the beginning of the AIDS
epidemic in California where the first cases of the Virus were made, much
attention of the scientist were in the area of the virus as possible related to
Cold Virus and much efforts are the beginning of the epidemics especially in
1985 when it became national problem, were centered on the nature of the Virus
and its mode of transmission.
Anthony S. Fauci “We may not ever have an AIDS vaccine in
the classical sense of being 95% protective….We still don’t know how, why, or
if a body makes a robust neutralizing antibody and T-cell response that can
both block acquisition and prevent diseases progression. The reason we don’t
know this, is because the body doesn’t do it in natural infection. With other
viruses nature tells just follow me and I’ll lead you to a vaccine. With HIV,
nature is telling us if you follow me. You are going to be in trouble. We’re
going to have a push the envelope with HIV vaccinology in ways that we never
had to do before.
I feel that as we problem the scientific secrets of HIV, we
may get there.” (First appeared in Victoria A. Harden’s AIDS at 30 A
History),…and by estimate the direction of the various seem to have changed
from its earlier emphasis on the Gay to equatorial forests of Cameroun…where a
certain Chimpanzee and some mentions monkey were said to have carried the
virus…where some of the older strains of the Virus where discovered. His statement simply echoed the fears of
others that we ‘we are unlikely even to know all the details of the births of
AIDS epidemics’
I, for one, met Fauci
in New York in advocating a different Glentil product and there was the
occasion to speak for a new product by the Pharmaceutical Industry. The meaning
behind the effort made by these Pharmaceutical companies towards the
Non-for-Profit organization is that sponsor projects towards new found
prescription drugs, and for that there is little independence on the part of
the part of the Chairpersons of National Agencies such as NIAID, NCI, and OAR,
which may receive additional fund from the State and from the City but the
large operational dynamics of the Medical Campaigns including Cancer and AIDS
sometimes force the agencies to look for assistance.
Victoria Harden (2012) pointing to Africa and describing
some of the basic HIV types associated with Africa, seem to summarize her
journalistic inquiries and historical analysis on the success and failures of
several new drugs…..There are other grants by the State and the City….
Multicounty AIDs program (MAP), International Olympic
Committee, PEPFAR – President’s Emergency Plan for AIDS Relief, FDA, NCI, NIAID
(National Institute of Allergy and Infectious Diseases) headed by Anthony
Faucci, CDC, and PHS, NCI director Sam Broder,
Up John CEO Ted Cooper, Aaron Diamond Researcher David Ho, Fred Robbins,
Frank Volvovitz; CEO of Micro-Genesys – Phase II, CDC, and the committee for
new trials on HIV backed by Fauci ‘Micro Genesys AIDS’ and the phase I – III,
of the AIDS VAX, which are roundly used in California ‘Vax Gen’ and the Vaccine
Alvac-HIV. From 1985 – as some people
has pointed out – that attention shifted from gathering information on the
Virus which preoccupied the minds of the doctors in the early years of the
discoveries to something else which was the rumor about the strain of the Virus
in several labs in the country.
After much exposition on the subject and the respect to the
six Haitian immigrants who were believed to have had the Virus from its early
years, in addition to the fact that two major individuals responsible for the
discovery of the Polio Virus vaccine, Jonas Stalk and Albert Sabin, where still
alive and active in the science community, the focus of most scientist moved
from gathering information on the mode of the code virus and why it was
affecting mainly Homosexual or Gay men initially to the source of the Virus. I
t is not wrong to look at the source of the Virus since our
knowledge of its origins may have armed the doctors with right tools on how to
kill it. But this theory of finding the source of the Virus should not have for
instance replace the best of practice of sticking to the objective information
on HIV, that HIV was giving us symptoms of being a kind of harmless virus on
one hand but delayed onset suggests that it was in original nature not without
potency.
Something must have conditioned the Virus in a softly but
yet deadly manner, as if the virus like Cold virus has passed through some
stages the virulent to the less virulent becoming an entirely unknown element
yet all the DNA intact reproducing and undoing the whole system. HIV was not
perhaps passed over as a cancer – personal position – since it is not exactly
connected to any decay of the cells saving the shortening of the blood efficacy
through the badly placed or disfigured three dimensional blood cell protein and
the diminishing role of Thymine largely manumission for T-cells.
But like blood cancers it strangles the immune system by
dissolving the thymus structure through a galactosides sugar complex
manufactured several bacteria capable of living in the gut such as E. coli and
Streptococcus, each capable of forming two headed phages immersed in the
protein core of the host. Yet their
presence which is a factor for life, which enables to life the help of cells in
of itself hence lie dormant as if never triggered, yet profligate in a life
form far from original process.
We have to credit the Chief scientist in the field, Gallo,
Montagnier, Simone, Gaaf, for mentioning that the death of many T-Cells are
attributed to the profligate HIV although it is linked to it. We may add here
that the constipation of low blood bearing oxygen and the suffocation of Red
blood cells, which trigger the death of Thymine due to poor release and
reproduction of Sugar or Glucose depended thymine and therefore a shortening of
T-cells which actively engage the HIV virus (that does not kill you) only in my
understanding and perhaps like others, that Thymine recognizes a chief interest
in the virions of HIV, that it is not without an interest or near sexual
attraction to it given its primitive origins, but cannot destroy it for reasons
since a version of human thymus cells its perhaps buried in cell structure of a
virion wrapped in its core by human protein.
In long lasting medical explicating, the virus continues to
profligate inside the cell without the acquired DNA which is RNA+ and human
protein built from either a bromide thymus or thymus though the primary engine
of life, alters the combination of Thymus to these foreign element by
reproducing similar Chemical bonding no different from those from a larger and
more active covalent thymine from human cells structure.
In a common and fanciful way of looking at it, like terms or
chemicals like exact composition do not attract. Magnets with similar polar
tugs do not attract and when a protein core wrapping a prophase bacteria or
Viral DNA easily create a gap between the covalent bond and link, shifting the
three dimensional blood complex and crystal, forcing the body into mood swings
similar to sickle cell and to some degree blocks the proper function of blood
and oxygen in the blood. It is a slow gradual cancer of the blood, that attacks
the thymus since it is originally foreign and needs to mate to speak but like
human cases, the CCR5 end up introducing gaps in the covalent link between the
foreign entity and the CD4, the thymus denatures and the system is porous.
Biologically, most cases on HIV – not unlike Cancer – usually die from other
things and not really the HIV which is a blood sucker.
In every sense, it is perhaps an argument that more than the
cases of the viruses or bacteria that were drug resistant and more than the
cases of the Kaposi cancer in men from New York who proved immune to treatment,
better than the facts about the Haitian immigrants who were not themselves Gay
or Homosexuals, there was something about the Virus that was ultimately in the
sample of cold Virus or an Influenza. There breakdown of human immune system
was the first act of the Virus, it was in fact one of the last acts of the
Virus which has successfully encrypted its existence in the cells of the host,
and there was damage to the body from drugs taken to cure the virus and the
final results were a system reduced to a self-destruct.
So we may have erred from the beginning by looking at the
late stages of a Virus life, and may have started to look at how the first
persons diagnosed with the HIV Virus was done when the virus was already in its
maturity, for sure there was the dry throat syndrome of cold, there was the
coughing and cold and victims being occasional wrapped in blanket and there was
the rashes, all consistent with mild cases of Cold and fever. If emphasis on
why the cold fever virus or symptoms where to continuously play a hand in the
overall business of the early experiments on HIV, perhaps the answer staring at
our face all the time would have been observed.
The incident of the blood testing between humans and
primates, and the role that plasmodium played as experimental dispatches on
early immunity compromises, between the primates, absorbs all of us of the
common theory that the most active elements in the blood types of these
primates, follows a pathway that meets the structure of human brain, meets that
speaking ability or mental compartment of human being, and the ability of human
beings to remain cognitive after so many years. It enters the connection
between the faculty of human beings and the production of very active
enzymes - either restricting certain
cells to profligate or serving as a form of instrument towards waste removal
from the body – in suggesting that a connection between the mental capacities
of humans and the blood types may be a lasting results of the testosterone and
the accompanying enzymes, that it mirrors for instance that men who are
castrated as the puberty or thereabout, assume abnormal behaviors that early
ends their existence.
In practice and as one Pepin pointed in his book, there seem
to be connection between the short lifespan of Eunuch in places such as Africa
– Ethiopia to mention – and the castration which leads to poor performance of
these enzymes in the body of the male. Sponsor the claim that the blood types
play a role in the formation or inception of any virus, it makes it clear that
the between what ….
But Ethiopia has its own history……
It is reasonable history that castrated Eunuchs – not just
in Ethiopia - do not live long, usually suffer from assorted sickness, ranging
from constant depression of the immune system or cold to dry lips and sometime
fever, sometimes they experience tears and abnormal emotions almost sinecure to
the female while they are still male. Tears and emotions for nothing…. There is
a part of them that has died or forced prematurely to denature and this is the
testosterone.
But the theory is in Imhotep (the conclusion; affirmation)
….’‘the power of the man, the power of his dick’, a lame translations in light
of today’s literature….Imhotep was a human being and was perhaps a Royal long
serving and distinguished Egyptian Secretary, organized several academic
discoveries into disciplines such as Architecture, Physics, Medicine,
Chemistry, etc, but couldn’t have lived for more than three hundred years since
many dated sayings where attributed to him long after his death. Imhotep is
three words or letters describing ‘understanding’ or a QED, but may be a seat
attributed to him following a distinguished career to Egypt and pursuit if
wisdom. Im’ho’tep (our understanding) is probably the same as Amen’hotep with a
slight difference, the latter is well known for its appearance in the Bible as
Amen or may it be so, or we affirm this to be so and so on, the latter arrived
in Egypt at a time when A letters were replacing the original K which is
probably the first Egyptian letter.
But the real theme understood by the Egyptians and perhaps
others, is that life of any human, and in this generic case; the man, can be
understood by the quality of what comes out of it; the Spermatozoa. The elder a
Pharaoh of Egypt the greater his prove that he was still virile. The more the
land tanks the more the Pharaoh is expected to prove that he is not responsible
and would demonstrate his livelihood and its spiritual awakening of the fertile
earth by coming upon the Nile – essentially masturbating until he releases his
spermatozoa on the waters, usually a public show privy to a few select priest
and elders. If Pharaoh’s fertility is the power of his dick, if it comes very
richly, the pharaoh was still called fertile, he will be absorbed of the short
period of draught over Egypt and he can consolidate all that through a marital
consummation and a child, a new and fertile Egypt.
When the Pharaoh is no longer fertile and the land no longer
at ease with new and abundant crops, the Pharaoh is expected to pacify the land
by taking his life, or entrusting his death to the Priesthood. A Pharaoh who
cannot procreate or impotent, need not disclose, need to keep the land busy by
traveling lands afar or engaging in raids to keep the mind of people from the
leathered course. Ramses II – Egyptian greatest propaganda Pharaoh ensured his
legacy by constantly having children even in his 90’s, although the severed
neck of Ramses III is a different story between a possible assassination and
the tradition that is as old as Egypt.
This short dicta beguiles the examination of the power of
procreation within the male testis, to be a beginning of the procreation, that
the first organic changes that could take place in life of living creature
begins to take place in the male, who should be called male and female having
the ability to produce both X and Y chromosomes, showing that the female is the
X mistaken as the default human, but to the ends of the protein which is not
DNA, it leads back to the centromere that the DNA or human genes is as
primitively described by Erwin Schrödinger is a ‘code-script’ that has the
clearest definition of life, that this life which manifest as a full grown
human body is a product of repetition of this code-script or DNA, which in his
definition is merely an addition, a kind of building block achieved in clearer
fashion By Watson and Crick as the Protein.
The X protein is a cheaper version of a process that is
intermediate between Erwin Chargaff and the earlier ascription of Hans Spemann
‘exclusion principle’, describing what happens during mitosis, the new cell
acquire new chromosome by excluding what it already has. The X proteins has no
life on its own, it is a youngest or the most advanced form of proteins, it is
therefore further away from the primitive Y chromosomes, that men inseminate in
so far humans as concerned is no co-incident. But the female exist only by the
exclusion of genes inherited mainly if not in my view only through the father,
making possible future mothers acting with the Y but not able to reproduce it.
The safest way to highlight why HIV as a two-headed prophage
or Viral DNA which must began its journey as bacteria, possibly a control or
inhibiting factor largely dependent on a mature operon, but bacteria inhibiting
factor at a primary stage such as streptococcus or in mordant association E
Coli controlling versions of other bacteria or fungi without walls such as
Candidiasis, that both Streptococcus and E Coli trapped in the guts of the
humans or most creatures, both of which contribute in part to human’s digestive
process, both like Candidiasis can invade the walls of mucosal membrane twig-like
appearance and retain their DNA in the formative of new Sperm.
It is not the liquid (Seminal Fluid) that can be attributed
to be a messenger or the information bearing RNA, but the very DNA of a human
being as experienced in the long studies of bacteria and injection of DNA from
one form bacteria form to another, is similar to Spermatozoa and its flagella,
as if on its most minute and multi-celled super-structure, the Sperm is merely
on a male parent body. It is this Sperm like F-factor bacteria that injects its
essence (DNA) into a pack of advancing or advanced proteins – mainly the X
proteins in female, retained in its embryo as the egg – that empties its DNA
into the XX egg protein composed of mainly a parent from similar XY male
ordinal, but have no F factor, cannot inseminate itself because in my view, it
descended from the Male so to speak her father but a second version of the same
line which can only or at least most of the time, recognize the male
counterparts which bears the original DNA.
But the male body is active and continuous, it reproduces
prolifically, its end product are a retention of a three months of body fluid
and mineral consumptions which always includes the bacteria and some endangered
chromosomes from the paternal lineage and are all conserved in a protein with
DNA attrition, the Sperm and the Seminal Fluid from its testis. Here, in the
life of a given creature, the process of protein synthesis and absorption
navigate between the presence of a male-synthesized protein – unlike the
females or foreign antigens which can still be broken by the human body – the
male body lacks this ability to synthesize male advanced proteins containing
the original DNA from his father and mother by induction, will prove capable of
holding its DNA as part of human male spermatozoa which made its way into the
body of the male leading to a possible two headed RNA+ Viral DNA, which makes
its way into the new man’s spermatozoa.
Ultimately the three
to four factors of the GATC which has been studied towards the manufacture of
drugs which for instance regards to patients of ADA, Adenosine deficiency whose
immune system from birth – even without the reversals from arrested viruses –
seem depleted to a point that they unlike those with damaged immune system from
the danger virus, end their lives as early it began. One of the examples of these viruses that
can create more than one havoc in the system is EBV viruses and which damages
the mononucleosis of an individual can create conditions that arrive the
Burkitt lymphoma among the Africans (Magic Shot) and can create the conditions
familiar with ‘nasopharyngeal carcinoma’ a cancer that is familiar with Chinese
adults.
The book mentions some of the diseases that are arrived as a
result of other viruses and bacteria which over the years have laid dormant in
the body by invading region in the body that tolerate lysogenic bacteria. The
fermentation of these bacteria inside a body and in the regions where they can
survive allows the bacteria to shade some of its proteins without removing the
Nucleic Acid which is central to its formation, but by incorporating the
information from the foreign body into own chromosome, means of retaining its
active existence in the body, through self-destruct management, and may remain
what may be called friendly to the system over a period of time.
When in 2007 Merck
announced that HIV vaccine (V520) was a failed experiment, that it was tested
with HIV negative people who became positive in terms of the vaccine, the
problems of who was used for these experiments became a public issue. But not
the answer is that some stories about the East Africa and others from Africa,
who seem to have started the Virus, took a bolder and more defensive show. That
these people who brought the Virus to humans were not without blame, and this
should also cover the candidates that were used as genuine pigs. Majority of
these guinea pigs, either from estimates drawn from science community or
inferential correlations of the supposed early years of HIV – dating in one
instance to 1949 – in Africa, may equally account for the high presence of
these viruses in South Africa, in Congo, in Rwanda and many parts of the
Continent direct associated with so-called Chimpanzee theory. It is this not
the medication that should run the gamut of the studies, for at specific levels
we have the doctors for it, or the specific studies of designer drug product
which follow the same track in the body, of different name but similar
function.
These pre-occupations
may either result from the stigma associated with HIV patient or the failure of
any victim justifying why he or she should contact it or suffer it. But with
breach in public activity and personal restriction to those with the virus as
we find in Ervin Magic Johnson, the virus like other diseases can suffer a
natural death. It will not be the first time that a condition such as HIV has
showed up in the history of world. There are similar cases involving the
disappearance of communities of interest in the time past, some of them like
Carthage other than the defeat suffered at the hands of Cornelius Scipio and
Rome was at some point decimated through a form of immune deficient diseases or
affiliation. The cause of that disease was not known, but like the Spanish flu
at the turn of the 20th century (end of 19th century), the disease came quickly
and ravaged both on the ship and on land. While the Spanish flu was airborne it
was also waterborne.
The Spanish flu was no different from Bubonic plague in
devastation, and the reasons why these infections took on a life of their own
was the lack of diagnostic of its origins, why it started saving the ships
mates brought the dead to the shore, or how it spreads saving that it seem to
many an air borne – that is, those who came in contact with the infected also
got the infection. The animus of isolation and quarantine proved a diverse that
broke the vicious cycle, but like leprosy and its age, many people were blamed
for the problems of these infections, some of whom were for instance Jewish,
who were blamed for the spreading leprosy, poisoning wells, and for spreading
the Black Plague. Not all doctors in the medieval ages agree that it was one
group who coursed the virus to profligate, rather the virus is a pattern after
people’s way of life, and such small attention to sanitary conditions were taken
seriously. Without finding any cures for these diseases and conditions, these
diseases gradually gave way.
The main point is
that the spread of HIV is only through the metabolized plasma of the patient
and a form or formal DNA, and could not proceed any other way saving through
the use and abuse of medical resources or through contact with blood. This last point is the bases on Randy Shilts
‘And the Band Played On’ where he chronicled the early years of HIV and
provided the detailed emphasis of Gaetan Dugas who considered ‘Patient Zero’ or
the first clear case of HIV patient and who according to Randy Shilts
consciously infected many other men, especially Gay men. The book has inspired
a lot of attention and a lot of other books, some of which were written by
people already got the virus including sororities determined to walk in between
the line of cure, experimentation, and infection.
To no small measure was the public perception of Kimberly
Bergalis who was considered a virgin and had not used a blood transfusion
charged towards protecting “innocent victims of AIDS”, that attention shifted
from understanding the processes involved in the virus replication to blaming
groups of interest for instance Gay men who in turn pointed to Africa, the later
as we learnt through history and chronicle of the virus became very early one,
a hotbed of experimentation. It is not a coincidence or should we pretend that
the blame game in the middle ages set against a minority Jewish group was not
set to absorb the rest of the society of the blame of diseases that follows its
own circle and feeds on human beings. It is common sense that some diseases are
genetically disposed of, but majority of infection are not, and the initial is
not transferable saving through procreation.
In no wise different is the contagion of HIV, whose life
circle is no confined to a region or people is badger for Africans from the
deep recesses of the Congo, for it is only in the names of origins of the virus
can medical companies use and abuse human beings through injection of vaccine
below the acceptable risk of new drugs. There has always been the issue of a
means to an end, where some protagonist cited documented cases on drugs or new
vaccines introduced into a public or working society and despite the many
deaths it caused; it proved a salvation for others. It is a case that points to
the Tuskegee College experimentation of Black male from Macon Alabama who
deliberately injected with Syphilis and left untreated for sanctioned groups to
study the effects of untreated Syphilis on human body.
One of the things I was privy to is the suicidal behavior
and tendency of the victims leading me to understand why in the end, preventing
the expansion of HIV was both dependent on the conscious decisions of the diagnosed and the attention given to
the lifestyle on those either not sure or those with redoubtable status. The
later may account for obvious cases of HIV transmission some of whom understand
the implication of their lifestyles but would rather play ignorant to a HIV
than face the emotional injury and social stigma associated with recently
diagnosed. It is not enough to claim that a socials stigma for HIV is not as
strong as may have been suggested, it is however a state of mind that welcomes
the cure is not yet available that leads to doomsday psychology. Majority of
the emphasis on this virus and patient is created in such a way as to suggest
that it is the sexual activity of some group of Americans, for instance the so
called Gay or Lesbian (?) or the African Americans whose nature is prone early
healthy sexual life, are those who are major players in the spread of the
Virus.
The other such as the Latino and Hispanic community has also
noticed a spike in the new cases, largely for the attempt at testing for the
Virus than other means. But in the end, the last two groups receive the highest
blame for the spread of HIV, whereas, anybody can infect others or infected by
others. These stereotypes, particularly the problems of expertise of the field,
Doctors or Nurses or Health Care experts, loathe observations by nearly anyone
without a badge of certificate or honor. As such only those who caught the
Virus and those with close family member with the diagnosed status that are
interested in the learning about HIV with a degree of interest. The rest of us
are incurable expat on opinions and diagnostic made available by those in
field, but by condition of more direct investigation of the Patients and their
drugs, we are able to see through the understandable but proud-ridden
closed-off of medical institutions; CDC (Center for Disease Control) and
private medically experts each seeking in their own ways to find the cure for
HIV – one of the Viruses that can lead to Immune Deficiency.
The reasons why these organizations react with disdain to
such things are many, including a possibility of Abuse and use of a medical
terms that need explicating to novices, but it seems that the terms and
conditions are no replacement for the Virus itself and why more can be done towards
a better understanding of the Virus, why it attacks or attaches itself to a CD4
host and why in the end, the Virus overpowers the immune system. The few stories which we remember from the
early years of the virus includes one concerning the Kaposi Sacoma which appear
in the skin of mostly HIV position homosexual male. The Candidiasis appears in
blood groups of mostly Hemophiliac and people with chronic cases of blood
thinning and Pneumonia. The transfer of blood played so significant and blood
management also played a serious hand in deciding early reaction to HIV and
from downtown New York was a man by Michael Rosenberg who dies in 1994 from
blood and HIV complications not before founding the Hemophilia/HIV peer
Association, which sort at least in New York to monitor blood distribution and
donation through the State.
An outbreak of contaminated Blood plasma in Tokyo a decade
earlier threw a lot of light of how the confusion between Hemophiliacs, Sickle
Cell, and Blood Anemic patient peered off with cases of compromised immunity
sped through blood donation and government officials and how they affected
people with HIV in New York and many other parts of the country. Whereas the
issue of blood transfusion and Plasma donation has been partly common in New
York due to a peculiar kind of immigrant entering through its harbor, it never
amounted to grave and deciding consequences until there were obvious problem of
pox developing in the blood of victims of a supposed newly linked virus. One of
the earliest warnings on the blood transfusion came from Susie Quintana who was
believed to have contracted AIDS through the process, but the litigations did
not arrive on time for her settlement which eventually reached 8 million
dollars.
Douglas Starr (Blood;
1998) describes the blood groups and the companies that made it possible for
the distribution of the blood around the world in what he described as ‘epic
history of medicine and commerce’ where the whole blood is known consisting of
Plasma which remain frozen after being emasculated from plasmapheresis which
normally aids in fractionation and by necessity of a form of dense
cryo-precitation treated with anti-hemophilic factors, and there are cases of
Albumin, Reagents, Anti-RH, applied as a contingent treatment but done so
slowly that it amounted to level of oversight, and some of the blood hematology
used in the time past, containing as they say life forms, in and Red Cells. White cells and platelets…
Like other breakdown in the body and the rise of the duplicitous
symptoms of immune-deficiency Syndrome, one of the more remarkable is the
presence of Candidiasis in the mouth, nose, in the mucous, and in other parts
of the body, including irregular bowl movement, nausea, headache, bloating,
vagina itching, the ‘Psoriasis’, purrs from the cell, Coxsackie, ‘loss of
energy’, depression, ‘loss of memory’, fatigue, …which are symptoms of HIV, are
also similar to the Chronic Condition of Candidiasis Syndrome (CCCS) which like
many other lytic cases or cystic, did not have to passage through the blood
of foreign donor or enter the body by
the contaminated contact, it may remain stasis up to a certain until encounters
transmit the changes. For nearly all viruses and bacteria that are capable of
invading the body is usually part of the body or part of its immune system,
does not mean that all cases which in this leads and yields to formidable virus
passage through the same process, but no culture which exist anywhere is done
without this process….
In some clarity it proves of HIV as a Virus acting from
within is not far-fetched, it is a fact that is well known, could have died on
the first person who made the contact with the virus but like funguses or
bacteria, it managed to survive.
Needs to play to this knowledge of HIV from the School of
Gallo and Montaignier on HIV, that the attention is not what causes the
symptoms but on what causes Pneumocystis and the viruses are observed according
to prolonged studies. These knowledge wounds and heals, for if we are looking at
the reasons why these bacteria and fungus-like structure are manifest in the
body, the main events include looking at the opponent of the virus or bacteria
that were once dormant, opponent which includes what it them harmless and why
they became dangerous, suggest that some conditions associated with these
complexes are permanent and therefore long-live in its harming.
For all these could not explicate on how the virus became
lethal over time, assuming like other viruses or bacteria it remains dormant so
to speak, and like other fungus-like structures such as Candidiasis, the
possibility that HIV is one of those dormant viruses or bacteria would not
never be achieved in the destruction of the cells that it finally wrought on
the body.
There is no telling that it is acting along other viruses,
no telling that other viruses like it also exist in the body to checkmate its
movement, it amount to a clear and concise remuneration that the virus did not
like candidiasis affect human immune system from a child level or before 6
months old, it observes that the primary attack properties of the virus is set
in such a way that it behaves like a dormant Type IV slow virus due to the lax
and sometimes delayed reactions of antibodies in the system meaning the last of
these defense system, which is IgG which is slow in its preparation given
ability to manufacture new DNA but generally built to effectively defend the
body and are found mainly blood, complement that HIV has at least more than one
pathogenicity, that it has more one elements in its retroviral structure, which
could be harmless because a virus or fungus in the body can checkmate on it,
and it has a secondary Viral DNA in its nucleus from a different source –
possibly as we have argued from human being – which allows to evade the system
as if it is a cancer to its system.
Toxicity is Type II defense protein, in its range of
relative defense mechanism is the cytotoxity of cells, it causes cancer as we
have mentioned where the body enables the development of the cells with its own
immune system to wage effective defense war against itself, hence a toxic site
or region given above all to the mutation that the cells encounters in the
course of its reproduction, it leads to less and less effective development of
the cells and then becomes cancers and little enclaves in the body, expanding
and consuming all the necessary nutrients it needs to continue its growth and
it is said at this point to have immortalized – so much that it spreads from
one part of the body to several parts of the body. The enclave is not unknown
and the comparison of cancer to HIV is not a new study, whereas some
studies
A chronology of CDC’s AIDS definitions
1983
Protozoal and heliminthis infections
(1)
Cryptosporidiosis, intestinal, causing diarrhea for more than a month
(2)
Pneumocystis carinii pneumonia
(3)
Strongyloidosis, causing pneumonia, central nervous system infection, or
disseminated infection
(4)
Toxoplasmosis, causing pneumonia or central nervous system infection
Fungal Infection
(5)
Candidiasis, causing esophagitis
(6)
Cryptococcosis, causing central nervous system or disseminated infection
Bacterial
infection
(7)
“Atypical” mycobacteriosis, causing disseminated infection
Viral Infection
(8) Cytomegalovirus, causing
pulmonary, gastrointestinal tract, or central nervous system infection
(9) Herpes simplex virus, causing
chronic mucocutaneous infection with ulcers persisting more than one month or
pulmonary, gastrointestinal tract, or disseminated infection
(10) Progressive multifocal
leukoencephalopathy (presumed to be caused by a papovavirus)
Cancer
(11)
Kaposi’s sarcoma in persons less than 60 years of age
(12)
Lymphoma, primary, of the brain.
HIV antibodies not
required.
1985
(13)
Histoplasmosis
(14)
Isosporiasis, chronic Intestinal
(15)
Lymphoma, Burkitt’s
(16)
Lymphoma, immunoblastic
(17)
Bronchial or Pulmonary candidiasis
(18)
Chronic lymphoid interstitial pneumonitis (under 13 years of age)
Antibodies are
required.
1987
(19)
Encephalopathy, dementia, HIV-Related
(20)
Mycobacterium tuberculosis any site (extra-pulmonary)
(21)
Wasting Syndrome, HIV related ……………………HIV antibodies required.
(22)
Coccidiomycosis, disseminated or extrapulmonary
(23) Cryptococcosis, extrapulmonary
(24)
Cytomegalovirus, other than liver, spleen, or nodes
(25)
Cytomegalovirus retinitis
(26)
Salmonella septicemia, recurrent
1993
(27)
Recurrent bacterial pneumonia
(28)
Mycobacterium tuberculosis any site (pulmonary)
(29)
Pneumonia, recurrent
(30)
Invasive cervical cancer (antibodies required)
(31) T-cell
count is less than 200 cells per microliter or less than 14 percent of the
expected level.
References
(1)
Deusberg, Peter (2003). The Invention of HIV
(2)
Selik, R.M., Haverkos, H. W., and Curran, J. W (1984) “Acquired Immune
Deficiency Syndrome, (AIDS) in the United States, 1978-1982.” The American
Journal of Medicine 76; 493-500
(3) Centers
for Disease Control and Prevention (1992). Revised classification system for
HIV Infections, and Expanded Surveillance Cases Definition for AIDS among
Adolescent and Adult, Morb Mort, Weekly Rep 41 (No. RR 17) 1-19…..
The information on
the spread of HIV from its early roots to the ends of the modern times has
featured all sorts of interesting notes, and may not be said to have exhausted
the list……It seems that some of the infections are not themselves caused by
HIV, that the virus is considered by many experts to be close to Slow viruses
of bovine and visna but are not saved by the end products which is cancer
causative with due respect to the plaque in the cell or what essentially leads
to form nerve wracking, decay and demethylation, for that these viruses which
may be classified as retrovirus are not themselves dangerous, are essentially trapped
in some restrictive enzymes where they grudgingly make all the damage. It the
list given to us show despairingly evident opportunistic infection (oi) it may
lead us to accept that the tools of coins between the viruses that affect human
being when the toxicity is expressed and the ones that remain in the body as
friendly viruses, which though toxic but are placed under some binary control
by growth inhibiting factor in form of a virus or bacteria existing separately
in the body, when such limiting growth factor is tripped or tampered with,
there is a presence in the body that proves dangerous.
Therefore it may
well be said, that a relationship between the toxic viruses and the non-toxic
viruses exist to the enabled degree that as long the count of some virus or
some bacteria remain within a certain level, there is a required relapse into
the fronting that a once friendly virus such as HIV or once friendly bacteria
such as streptococcus are no longer friendly due to their expansion and feeding
on the host, due perhaps to the attacks that the body received from the very
elements that support both the bacteria or the viruses that directly occupy
sensitive LTR regions of protein replication. We may compare that the
differences between viruses that are friendly and the once that are not
friendly is based on how they profligate in the cell. For if we compare the
removal of some of the CD4 from the body due to the actions of the system to
protect itself, you have either a body that is recklessly prone to
opportunistic infection or in terms of HIV you may have a body that can
withstand the virus.
It is an academic
accusation that the role of CCR5 in the cells structure of protein, is so vital
for the survival of the virions that the reasons exist directly that the role
of CD4 in helping to ward of viruses such as RNA + viruses as such
Streptococcus that multiply on their own, the CD4 in helping to fight HIV
essentially primes the body into a situation that has no escape. In shadow of
the discuses on HIV, we may look at the presence of the above diseases in the
above charts by CDC, and compare to what extent that these viruses been
observed as part of human beings. Nearly all these viruses are not new, nearly
all these viruses are not destructive, many of them fungi or bacteria based
still remain in the body for long spells of existence, for instance
Candidiasis, may only multiply according to the limits which was formerly
placed on it. For a fact, the case of Kaposi Sacoma could be called a kind of cancer
given the presence of the Src genetic based oncogenic for Sarcoma, that it is
characteristic of those who suffer Pneumonia or they call PCP, impales against
other facts that these were product of ordinary immune deficiency than anything
else, that these men had a lifestyle that included recreational drugs
Distempers medical
reaching that it was a new virus that caused AIDS….
It does not mean
that a new agent is not elemental to the virus it does not mean that agent is
removed from the humdrum reality of the very reasons why most Gay couples and
sexually deviant homosexual were the culprits. The virus could have come from
anywhere else, also means that the virus may be living its secondary existence
with an astute approach to profligate that is similar to one, the viruses that
been tripped in its balance –which though should lie dormant in the body and
remain as a friendly virus was now virulent given its new ability to spun
toxicity. The other group that may show a disappearing comparative between HIV
docked inside the cell and expanding, are the very slow viruses that feed off
the cells. What from experience in the lab is said to constitute this phase
level activity on a bacteria, is based in part on the work done by Delbruk and
Sal…., which was carried through by David Baltimore, that plaques – no less or
more than what is found in the cells are seen as leftovers of a bacteria or
virus expanding beyond is provisions like Algae and some E.Coli left overnight
in a flask, where the flask temperature helps to profligate on the bacteria,
but in the end, when much of the yellow stains are removed, there is a plaque
at the end.
The toxicity of cells when they become title tumors able to
support their own existence, or when they become immortalized that cells divide
on their own, leaves us several theory that the virus behaves like Bacteria, as
if it a multi-cell organism, explicates why multi-celled Eukaryotic bacteria
survive on their own and in the body of the host, earning its own requirement
from the host within losing its basic DNA or Chromosomal inheritance. For this
explains why there is a transfers as Lynn Marquis and Sagan wanted to
demonstrate that though there are Eukaryotic cells that have their viruses, it
is the ability of cell support its own existence that transfers it from single
cells to multi-celled organism.
Playing backwards it is impossible to deny that these
movement of a single celled fungi and a single celled viruses, could not
support itself own existence saving that it attached itself to the host, that
in spite of what we now know as the difference between the S strains of some
bacteria and R strains, there is something about DNA and RNA that separate a
virus from a bacteria, something about the RNA
to RNA dogma familiar with transcriptase that will point to the
existence of two separate viruses enclosed in a what is called HIV nucleus
capable of supporting itself through the enzymes, operating as if it was a
multi-celled that is more than one virus and since the virus and the Amino Acid
of the HIV is RNA+ are said to profligate but less than the vicariate and
hierarchy of a bacteria, it means that the retro-virus of HIV explains its own
history, that life became as a constant addition of two probable entities – the
root of which is perhaps the trapped hydrogen determined bonds of a DNA which
is itself perhaps two RNA of some unofficial verity.
In elder language, the two RNA that conform between the DNA
and RNA and vice versa, away perhaps from the central dogma and Crick and
Watson deposition of intracellular hierarchy of DNA torching RNA and RNA to
protein, may illustrate that the bacteria as more than single celled, is a
product of several mutable Ori sites in the body or derived from elsewhere,
perhaps of similar or discolored Carbon electron transfer that affect the sugar
construction including those of blood cancers as Insulin misreading and diabetes,
sickle or recurrent cell anemia due to porosity of oxygen bearing hemoglobin –
itself a defense mechanism – and the externality of RNA antibody that is no
wise different from the dialectic of cancer, oncogenic cells and genes,
immortalized and replicating to the point that if a man or woman dies during
this constant replication and fed by bacteria from without, the body has a way
of changing the biological dynamics of the bacteria itself, though friendly may
from the zoonotic of human or animal carcass become agents of diseases such as
typhoid or dysentery.
The Special cases such as Hepatitis, adenovirus, Coxsackie,
varicella, human herpes virus type 6 (HBLV-6), Cytomegalovirus, Herpes Simplex
type I, and measles, for these isolated groups of interesting infectious
disorder, are well studied and have easily occupied the time of medical
communities in the world. Some of these are no longer the first light on the
concern of big world organizations such as the UNID, MAP, and the engaged
efforts of NIH in Maryland, there are other concerns like those of Malaria
which has been reported to have claimed more live than a more primary problem
of HIV, and the foundations such as Bill and Melinda Gates Foundations have
added luster to the efforts in eradicating Malaria parasites, to providing new
tools for vaccines in India on the final notes that Polio is eradicated.
Several measure of efforts on HIV including international
corporation working for the general good of the world, are variously involved
in the pursuit on new curative for viruses such Ebola which is also recent,
viruses such as Measles when and if they occur, and the permuting need for
orally delivered live-virus, BCG which the French developed and MMD, which the
English developed, along the vaccines here in the United States, part of which
is the saccharine and starch passaged and tested cold flu viruses, authored in
the United States every year.
In one case worthy of the trouble is the recent breakout of
Ebola which is reasonable close to the instances of Lassa Fever - not unlike
Yellow Fever – are different on account of the source of these viruses; the
first seem to have arrived from Rats and the Second from Mosquitoes, and are
quoted by foremost authorities on the subject to have come through Africa. All
the named variously are known to have reached United States through Africa and
Africa for this reason has been the interest of preeminent scientist of the
world.
In Robert S. Gottfried ‘The Black Death’ which was set in
order of F.A Gasquet 1893 ‘Black Death’ we find him discussing that “Important
as small pox and measles were in the natural history of infection disease,
their combined role was dwarfed by the arrival in 541 of a third disease. This
was plaque caused by a complex series of bacterial strains called ‘Yersinia
Pestis’”, he went on to argue that the Plagues etiology demonstrates ‘Y.
Pestis’ toxicity varies, but the diseases is always highly lethal.’, that it
lives “it lives in the digestive tract of the host “black flea” while feeding regurgitates
into its victim large numbers of Y-Pestis bacillis.” In the end, we find that
people’s inability source the mode of transmission of the Bacteria into the
body made them prey to the dangerous nature of the killing plague which
devastated Europe from 1347 – 1351 and killing up to 25% of the population.
It was most probably inhaled and in recent times, at least
at the turn of the 20th century, there was a similar outbreak of Cold Virus
resulting in the body of its victims turning blue-black. This Influenza wiped
off the people in the Ship and their boat never made to ground and died every
one of them on board. The Ship was discovered in some abandoned placed, half
docked and crash landed. Someone mentioned that the silence of the crew which
included renowned doctors of import….It is possible to suggest that
relationship between these kinds of Virus and Bacteria is that the Bacteria are
single celled organism that needs oxygen to survive on its own. It can also
spread as rapidly as any
Robert Koch settled the issue of Diphtheria, discovered the
virus that caused Tuberculosis, but in 1892, in the United States it was Walter
Reed that discovered that Yellow Fever is transmitted through Aedes mosquito,
and according to Rita Mary King ( ), by the end of that decade, Joseph Lister
in England developed aseptic to prevent infections.
Molly Caldwell
Crosby 'The American Plague'; 2006, 'the untold story of Yellow fever' for
instance describes the problems with the victim’s body as this that "The
Virus attacks every organ, poisoning the body from the inside out. As the
immune system fights back, temperatures run as high as 105 degrees, and the
patient grows delirious. The body gives out. It hemorrhages, running red from
the eyes, nose, and mouth. Vomit, black with blood, roils. Then, the fever
leaves its mark, tinting the skin and whites of the eyes a brilliant yellow,
giving the virus its infamous name; yellow fever" This paragraphs is by
many designs derived sources which were popular about Yellow fever and what she
however adds to the story is the dynamics of the Virus from purely academic
point.
Rare cases of yellow fever in our time are hard to come by
and the virus seem to have passed from Mosquitoes carrying a fever virus called
Flavivirus from supposedly West African country and spread among the people in
Mississippi. That once inside the body of the victims, its hijacks the cell and
its 'basic machinery' and would use the cells dynamics to "replace the
Viral proteins and RNA, until the particles burst through the cell." In no
distant time a body full of healthy cells would in no time be riddled with
virus carrying the 'yellow fever virus' and for this process "anything
that could destroy the virus might also destroy the cell", she said.
In a World Health
Organization rap sheet on Malaria transmission and the Malaria causing
Mosquitos; January 14th, 2014, the sheet, clearly pointed that “Malaria is
caused by a one-celled parasite called a Plasmodium. Female Anopheles
mosquitoes pick up the parasite from infected people when they bite to obtain
blood needed to nurture their eggs. Inside the mosquito the parasites develop
and reproduce. When the mosquito bites again, the parasites mix with its saliva
and pass into the blood of the person being bitten.” The sheet continues that
“Malaria parasites multiply rapidly in the liver and then in red blood cells of
the infected person. One to two weeks after a person is infected the first
symptoms of malaria appear: usually fever, headache, chills and vomiting. If
not treated promptly with effective medicines, malaria can kill by infecting
and destroying red blood cells and by clogging the capillaries that carry blood
to the brain or other vital organs.” These symptoms of the body over-powered by
these mating Mosquitos it’s not the same in every person, does not also affect
anybody in the world, like the saying goes in Africa, Mosquitos do not even
bite everyone at the same rate.
It has preference for
blood types, and the rate at which it mounts proboscis on any person sometimes
measures the level of demand for a person blood type, that those with classic A
Antigen blood group are more than likely to suffer from these attacks from
plasmodium, a relay that like Red Bugs and Bed Bugs, the bites from insects can
be due to a blood type, and the reaction to these germs in the body can also be
brutal if not demanding to such persons including consisting scratching of the
hands and the legs or in facial irritation leading to headache. The rest of the
problems that warrants death is the failure of an active T Cells from matching
the replication of these germs in the body, at a rate that suggest a mature
germ which must feed on the host ridden from body of the Anopheles to a
different host, in exchange of a blood from such a person.
In all reality, the structure of a HIV positive RNA is
digestible by an anopheles that the connection to Plasmodium is not warrantless
lead search towards understanding why the HIV attack Plasma, both pathogens or
parasites are dependent on Plasma, but the Plasmodium induced Malaria, it’s in
all, a foreign entity, that may paralyze a victim for a few weeks but not
permanently locked in pitch battle like HIV.
“There are four
types of human malaria: Plasmodium vivax, P. malariae, P. ovale and P.
falciparum. P. vivax and P. falciparum are the most common forms. Falciparum
malaria—the most deadly type—is most common in sub-Saharan Africa, where it
causes nearly a million deaths a year.”
“In recent years,
some human cases of malaria have also occurred with Plasmodium knowlesi – a
species that causes malaria among monkeys and occurs in certain forested areas
of South-East Asia.”
In account that shed weight on chain of discretion from
older times to now, we may look at the work of Tsetse Fly, and the direct
association of the a fly to the introduction of trypsomania to the body which
when transferred to second body, causes the blood sucking pathogen to feed on
the Red blood cells leaving the victim seek and weak, to the point that the
furious replication of the virus in the body led to weaker and weaker immune
system and eventually to the death of the patient who was recently infected.
The Colonials in parts of South Africa who died in some
numbers because of these diseases were privileged by their education and by the
use of stethoscope to fight back on these killer diseases and in this case,
there was a certain David Bruce who came fresh from the wars on Crimean fever
which was the course of the Malta fever where he isolated a bacteria
‘Micrococcus melitensis’ from the spleen of men who died from it, to Africa on
assignment by the English Majesty.
The main event was discovery of the source of Tsetse fly and
where he isolated the agent for it. John Mckelvey, Jr., (1973) makes out this
history, revealing that the commission to go to South Africa led him to
discover that “the Haematozoon or Blood Parasite of Fly Disease” which left
what we know as fragment of its DNA on the host, and the DNA proved a blood
sucker which the fly essentially retract upon maturation. Here, the examples followed by Bruce David
were those of Karl Joseph Eberth, Edwin Klebs, and Robert Koch, and in his time
was said to have produced the Sodium B-aminophenylarsonate- NH2C6H4A5O(OH)ONa,
all in other of a quinine manufactured by Klebs to counter the diseases
malaria.
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We have taken a better look at the leading arguments on the
transfer of virus from humans to other primates such as the Apes and the
Chimpanzee and a transfer of virus from other primates to human beings in both
epizootic and zoonotic biological proscriptions. But the argument has no
stretched far enough and it is within the construct of independent human
psychology and process of thinking to
It is this entangled web of consideration separating one
form to another that determines the left and right of the cases involving HIV
and human in context every situation, and above all, in context of the
difference between attitudes to blood and body types in names of blood and
virus profligate.
The primacy of the blood groups which separate a Chimp from
a Gorilla, a Gorilla from a Human, to a narrow a channel of the body’s ability
through the nasal cavity to manage its varying degrees of defense system which
will help its existence on the merits and demerits of an infection status and
use and abuse of HIV as a human virus independent of the environment in which
it exist….
This argument has been advanced in many direction and by
many medical experts that it is fitting to suggest that nothing remains of the
doubts that humans and primates separately suffer from cold virus and
influenza, but the components for any of the many primates
Like we mentioned above, there are exception to this
situation and one of which can argued from the composition of the highest density genes such those with the
only carbon copy of 22 sugar genes. This sugar complex tend to be ranked higher
than others with tendency towards the release of insulin in the body, may be
relevant in its variation of the population they tend to form and as such a
given biological population is probably one evolutionary pathway whose
frequency is lower than those of higher density and whose overall number of
sugar complexes is 22.
In any case, there is a chance the total number of genes and
biological functions that can be discovered in a section of Africa is equal to
the total amount of genes – either through mitochondria or through the Y
Chromosomal inheritance - to the amount
of genes available in all of United States including those of Africans and African
Americans.
Total amount of genetic information that can be found in a
small city in Africa will match the total amount of genes available in all of
Russia and all of China.
As far as Nigeria, it is estimated the Nigeria alone has
more genetic diversity than any nation in the world. Why? The answer is well
known from all scientific information that Africans are higher placed on the
density of gene protein, a fact that has been taken for granted yet probably
useful in throwing all kinds of light on why for instance a man such as Simon Flexner
was right that all Polio Viruses are the same, and why the attempt that at
correlating the HIV variants to animals of the Upper and Lower Apes kingdoms –
the so called cousins – is not only misleading but totally flawed.
For sure we may indicate that based on half the process
associated with genetic breakdown and studies; there is an equal measure of the
distribution of genes in theory which will not comply with the tree version of
the variant explication of human types and specie that relates to HIV in all
its form. But this variation between one variant of HIV and another, for
instance between HIV 1 through HIV 40 and perhaps more expanded as the case may
be, may be due to variants in human body and composition of genetic materials
in human body.
Let us rehearse some of the information about human beings,
that there is a tone of body types and differences between one pool of human
genetic information and another, that the races as we have them today and the
types of human beings as we have them from
previous eras and have seen them from all encounters and from all works of life
suggest a composition of human genetic materials and proteins that derive from
parents. This is the nature of HIV and immune deficiency syndrome.
No one human is exactly the same in its order of genetic
material - with or without respect to any source of vicariate event or
epigenetic demonstrated by Jerry Frodo and Massimo Piatteli - Palmarini such
that one person at one genetic end of a spectrum is different from the other at
the opposite side of the spectrum, that leads from the fact that the
differences between humans are based on present continuous cases of protein
arrangement beginning from the Meiosis and conception to maturity relevant to
hereditary.
I for one, do not need to shed all these light on the
present fact that Charles Darwins' theories on human evolution is not wrong,
but the pathway he eludes and derives his arguments from do not tow any useful
biological construct saving for cases of cancer and deleterious manifestation
as mentioned by many experts.
It is this variant that is a product of the many sorting
processes in biology and why on primary level humans relate to each and at a
certain level they differ. It leads elsewhere that attempt to transfer this
minor changes in human beings to primates with argument based mainly on
duration, fracture and adaptation, as if the biological construct need no magic
to grow given its necessity to survive, is not expected to survive since the
time frame separating one primate from another - in spite of archeological
evidence is inviolable due to the constant energy structure of the world.
There are therefore no possible new creatures given the
basic DNA structures underlining all animals on earth, there is therefore no
possible difference between one animal from another in terms of time line and
in terms of the age of dinosaurs whose basic animal structures contain as much
underlining DNA as does all creatures including Hippopotamus and the varied
humans and other primates. This fact need to be understood in other to score
any chance of understanding HIV.
In my direct view - based on my many years of studies -
nothing can account for differences in human being; both in nature of the races
than the speciation of genetic materials. The relevancy of the statement is
derived from some favored knowledge of history and from general and specific
assumptions about current studies in genetic studies which tend to suggest
separate existence of HIV structures with separate origins, whereas these HIV
viruses and SIV viruses wouldn't have been an obstacle if we understood the
genetic difference as a question of the region which it profligates than
separate pathways.
If we can also put some measure of intellectual force in understanding
that evolution or transfer of viruses from one primate to another is not easily
achieved and may be depended on the particular nature of the virus especially
the rapid and fast viruses such as Ebola or other airborne and injected viruses
including for instance Polio Meningitis and not necessarily the Lentivirus or
slow virus which adapts to its host and vary in its population of the creature.
A lentivirus adapts to its host, like oncogenes from Zaire
chimps out of which a strain of the Polio virus was used in preparing the
vaccination - cooked or alive. A strain
of slow virus from any one of the primates does not easily transfer to other
primates saving for direct cases of rapid profligate activity of the virus
between gp 47 and gp 120.
Once we have become conversant with a Retro Virus such as
HIV and its operational dynamic, it becomes self-perpetuating to relate the
number of variants to a process as opposed to Spill overs. Put it bluntly, there is one form of HIV
existing in the world, one strain - a personal dogma - that in spite of the
assorted phenotypes of the HIV 1-7 (HIV 1-19) we may be looking to a
degenerative protein quality of all Viruses as opposed to new types, such that
a flu virus mirrors duplicity and its tendency towards new forms from old.
One of the principal reasons for this fast and slow virus
profligate in the human body is the activity of the antigens. It seems that
certain cells in the human body only allows us to subdue new materials entering
the body and the body's reaction to foreign antigens is particular the work of
AB antigen and its suicide mission and the role of T-cells. It is easy for
Gorillas for instance to withstand any hint of HIV from human beings even as
co-primates given the very structure of their blood types such as B blood group
only, that they have a longer stay on processing new infection or exposure and
may die from SIV, immune deficient related diseases and other versions of
lentivirus without notice given the granulations of the B cells and its
propensity to condition the virus in their system. These types of viruses are
necessarily cancerous, necessarily a leading course of animal degenerate
condition such as blood cancer such as sickle cell and HIV which I for one
believe peritonea.
The issue of graduation and duration between humans and
gorillas can hardly be true, for all intents of understanding that slow viruses
tend to split as quickly as does fast viruses that memory cells play important
role in harnessing and understanding the nature of these cells - especially in
humans - and in animals as the case would suggest - that some of the enzymes
such as Cortisone may be a natural occurring material in the body from a blood
sequence naturally rich in B cells.
It may seem to suggest that the B part of the blood may have
to do with a promoter of some sort and not necessarily a gene that
superficially code for any type of blood crystal structure hence what they call
memory cells has all the cards in understanding Gallo arguments and Montagnier
arguments and has all the points about the reasons why HIV may invade immune
system, may lack vaccination, may above all be a virus that has both cells in
its mast, especially the human cells encased in the prophage, for instance
E.Coli or Pneumocystis which excrete a peculiar kind of sugar (complexes) that
dissolves sugar complexes especially Thymus structure in a basic DNA strand,
capable of temporarily altering the final structure for hemoglobin and
distribution of oxygen in the blood leading to collapse of the protein and
death of red blood cells.
There are several lines of defense in immunity complex of
any virus and creature - which from a personal dogma is made possible through
the testis of the male where the earliest or primitive reproductive processes
began.
Whereas no relationship seem to exist between people with
ABO blood types and those with Alzheimer’s - a different argument - which is a
process of decay and plaque accumulation from failure of the blood to remove
calcium or other minerals from the brain and the blood - a case no different
dysfunctional blood plasma and oxygen storage and other forms of human and
animal structure.
It may mean that those with O bloods in of itself, do not
behave like say Chimpanzees for reasons of body structure and composition and
those without B type in human beings do not behave like Gorillas for similar
reasons which requires minimum interpretation.
If the body fails to remove any major mineral from the blood
if settles somewhere in the cells or in the walls of the cells, and over time,
it builds up like plaque in the cell and give problems which the body did not
anticipate, a case no different from body fats and cholesterol which advanced
HIV cases suffer and HIV drugs capable of dissolving these residues in the body
also drains the body.
--------------------------------------------------------------------------------------------------------------------------
The relationship may therefore be limited to other factors
such as the ability of the Chimp to produce the Sailic Acids, an agent that may
have resulted from other genes lacking in the Chimps body as opposed to the
primary roles of the Sailic Acid in the body - perhaps regarding the
respiratory system given the production of mucous membrane, all of which may or
may not be reduced to the 450 missing total genetic information separating
Chimps from Human which influence attitude of the body to foreign invention and
the regularity of the body's removal of blood from the system.
Some these genes in Humans may be sugars and acids that are
available in humans and not in other creatures. But since it is the rooted in
the structure of the Chromosome, that is its productive side, it can be said
that the basic structure of these Chimps with due respect to Y chromosomes is
from it’s probably origins dissimilar from that of the humans.
In essence, a human beings may lack the ability to produce
these sugars which suggest a kind of subduction or descent and not nearly
‘ascent’ as in the man, a lower construct if does exist will be a comparison to
Human’s closest and richest genetic information reservoir, the Black Male. The
African Male/males
We point to an example of the popularity of an idea that has
no foundation in biology, that as much as Peter Medawar proved beyond
reasonable doubt that some infection do occur during transplanting a part of an
animal to another, but he limited his ‘Art of the Soluble’ to immunology of the
two comparable set of creatures, that the blood types of any-one willing to
receive a new body part from a donor should at least in principle be
comparable.
That what was killing patients in England was the general
oversight of the blood types, a theme that is not far from enzymes from DNA and
molecular arrangement of nucleotides, assumes to be correct in so far as the
blood types and groups of Chimpanzees are different from humans and in many
ways, the plasma may contaminate but in so far as the promiscuous origins of
new virus from seemingly mutant and dormant bacteria, the process is generally
a-biological.
Peter Medawar (England) and “did the basic research which
brought to light the problems of tissue and organ transplant techniques and
immunology – in 1967 – discovered acquired immune tolerance factors that oppose
tissue transplant.”
This fetched him the Nobel Prize but also a lasting standard
on the comparing the blood types of English patient, there was the limiting
issue of infection which was later resolved in America through the
demonstration that Histones or Methionine which penetrate blood cells and ease
the transfer of blood types, inhibit the penetration of some of the bacteria,
in many ways than the one, the presence of Histones which can replace Arginine
in the chain of Amino Acids, rich in the three layers in lysine and in the
third Cytosine, are mainly and directly responsible for some of the differences
between Hemophiliacs derived from parents and Hemophiliacs resulting from an
Influenza, for all its intent of purpose and use we can show that the passaging
of some of the blood from the blood cells of some of only leads to what is
true, that mainly all viruses tiny enough – even at the absence of histamine
that penetrate through some cells – are viruses capable of surviving on their
own. In the blood types and the competitive K-ishizaka (U.S) discovered gamma
globulin E (IgE), which also present at some level in serum? Serum makes its
clear…..
There other foundations of Biology and medicine that are
important, used in part by Peter Deusberg in his arguments against Gallo and
Montagnier that viruses capable of causing epidemic should be new viruses – set
in order of Koch – where the theory was also placed in different in terms of
(Farr) on the veracity of a New Virus.
While we may indicate that the whole statement raised by
these experts are true, they are true to the extent that the body could easily
adjust to changes in the body and in the environment if and when the exposure
to the system do no prove fatal. It is taken that these viruses capable of
destroying the body in slow or speed motive are doing so for many reasons
including that the body and CD4 cannot keep up.
However there is no going that HIV is an infectious disease
in keeping to Deusberg and in Order of Farrs - HIV viruses do not meet the
criteria for infection, adding that the virus is considered a retrovirus
essentially to the careers of Gallo, Baltimore, and Montaigne, whereas
retrovirus and the reverse transcription of RNA to DNA and DNA to RNA through
an enzyme, means that HIV could have been the reasons for AIDS as according to
Deusberg, but in all, shows that the total damage that the body can sustain is
sufficient to satisfy its healing and its cure so long the exposure does not
directly and indirectly kill the system composed mainly of active cells.
For that, there are chances that the bi-product of the human
body which are physical and which separate us from each other, can traces of
the returning few months and carry viruses and bacteria that the body pushing
out.
In practice, the total amount viruses and diseases that can
exist the body or at least circulating within a given community may be
considered relatively comparative to the amount of human activity in this
period, may remain within the comparative ration until unusual activity such as
industrial expansion or disease bearing animals not familiar with an environment
and ecosystem interferes, then there is event horizon.
From the levels of the DNA philosophy and the ordering
knowledge of the Sciences available to us today, there is no question that it
is a mistake to view without reason or even without books, that a certain virus
could possibly exist somewhere in the Universe that do not have the basic DNA
familiar to mammals, that do not have a basic structure that can be understood
and tampered it, and can be used in experimental isolation of several key
minerals in the body or in the body of the animals which they came from.
For instance, a Histone and Histamines are minerals based
Enzymes that can be extracted from Birds and Calf as well. Histones are found
in the Calf Thymus and in Spleen and Liver of bovine mammals, but in all, they
can also be found in the Spermatozoa of these Bovine creatures.
Between the Thymus of Calf and its Spermatozoa is one
product that are found the in the mucosa intestine, will not propelled a
connection between Thymus and Spermatozoa, ready-make the answer the secret of
mammalian existence in the final product or Spermatozoa. We seem common that a
different exist between the HIV and HLTV viruses given the structure of their
heads in the aspects of the protein that enucleate these viruses. The helical
difference between these two viruses and the part of the wine…
That the human body, by some means manages to regulate
itself through signals towards the release of enzymes, which from the Age of
his writing and even now, leans towards digestive system. The connection of
poor performance of the Pancreatic juice is not unrelated to Insulin, which he
created to have argued as responsible for ‘diabetes mellitus’ or cancer of the
insulin.
A measure of his theories about the body and its regulating
ability is in the of Science known to more concerned to the role of Chromosome
5, the Chromosome that enables that body to regulate itself through the
adaptive mechanism of the nasal which connects to the ear membranes where the
major sources of Cold Air for instance are usually passed from the external to
the internal.
The explicit role of the ‘Histamine and the Tubermo Nucleus’
(Myron Scholes) in managing the brain (hypothalamus) reaction to temperature
towards the release of enzymes in the body, has been extended to the areas of
Alzheimer and Schizophrenia, with view that the changes that take in human
brain may be due to internal factors other diseases which was initially argued
as hereditary.
The aspect of histamine and the association of histamine to
fever and influenza (flu) now elaborates on the works of Bernard but clarifies
the role of the RNA proteins in exchange of information between the brain the
current temperature of human body, that it is entirely possible to catch cold
from freezing largely due to the body’s ability to relay as much information
through the hypothalamus towards a defense system which can be altered even
without foreign elements.
There are chances that the bi-product of the human bodies
which are physical and which separate us from each other, can be traced to the
last returning few months. How the body carry viruses and bacteria that the
body pushing out.
In practice, the total amount of virus and disease that can
exit the body or at least circulate within a given community may be considered
relatively comparable to the amount of human activity in this period, it may
remain within the comparative ration until unusual activity such as industrial
expansion or disease bearing animals not familiar with an environment and
ecosystem interferes, then there is event horizon.
From the levels of the DNA philosophy and the ordering
knowledge of the Sciences available to us today, there is no question that it
is a mistake to view without reason or even without books, that a certain virus
could possibly exist somewhere in the Universe that do not have the basic DNA
familiar to mammals, that do not have a basic structure that can be understood
and tampered it, and can be used in experimental isolation of several key
minerals in the body or in the body of the animals which they came from.
For instance, a Histone and Histamines are minerals based
Enzymes that can be extracted from Birds and Calf as well. Histones are found
in the Calf Thymus and in Spleen and Liver of bovine mammals, but in all, they
can also be found in the Spermatozoa of these Bovine creatures.
Between the Thymus of Calf and its Spermatozoa is one
product that are found the in the mucosa intestine, will not propelled a
connection between Thymus and Spermatozoa, ready-make the answer the secret of
mammalian existence in the final product or Spermatozoa. We seem common that a
different exist between the HIV and HLTV viruses given the structure of their
heads in the aspects of the protein that enucleate these viruses. The helical
difference between these two viruses and the part of the wine…
That the human body, by some means manages to regulate
itself through signals towards the release of enzymes, which from the Age of
his writing and even now, leans towards digestive system. The connection of
poor performance of the Pancreatic juice is not unrelated to Insulin, which he
created to have argued as responsible for ‘diabetes mellitus’ or cancer of the
insulin.
A measure of his theories about the body and its regulating
ability is in the of Science known to more concerned to the role of Chromosome
5, the Chromosome that enables that body to regulate itself through the
adaptive mechanism of the nasal which connects to the ear membranes where the
major sources of Cold Air for instance are usually passed from the external to
the internal.
The explicit role of the ‘Histamine and the Tubermo Nucleus’
(Myron Scholes) in managing the brain (hypothalamus) reaction to temperature
towards the release of enzymes in the body, has been extended to the areas of
Alzheimer and Schizophrenia, with view that the changes that take in human
brain may be due to internal factors other diseases which was initially argued
as hereditary.
The aspect of histamine and the association of histamine to
fever and influenza (flu) now elaborates on the works of Bernard but clarifies
the role of the RNA proteins in exchange of information between the brain the
current temperature of human body, that it is entirely possible to catch cold
from freezing largely due to the body’s ability to relay as much information
through the hypothalamus towards a defense system which can be altered even
without foreign elements.
We may suggest that the chain of discretion between Robert
Gallo and Luc Montaigner survives differently, that for instance it survives in
similar work of some of the latter day scientist, especially in HIV emphasis
and Zaire strain of Chimpanzee.
Following the footsteps of Robert Gallo and perhaps an
effective scientist on his own right is Jaap Goudsmit, who like Frederick
Sanger, developed major interest in the biology in ways that were not exactly
placed on perspective, particularly in HIV studies where he is considered one
of the foremost authority on HIV, Beatrice Hahn, Myron Scholes, Michael
Gothlieb, Michael Popovic, Jay Levy being among the notable names, of course
Myron Essex of Harvard School of Medicine and Myron Scholes of North Carolina
could be added, but these are primary list, associated with specific invective
and are schools on their own including
David Baltimore.
In Guadsmit (1997) we try our faith on the virus in the
context of the life-strain which has been in the possession of Gallo, for all
intent of academic reasons, there is a mention that a familiar kind of strain
used in navigating the earliest promises of the viruses, and his book, ‘Nature
of AIDSD’ is a 1976 “isolate of (strain HZ321) is our earliest actual of HIV,
since no virus has yet been recovered from the Norway sailor” and this isolate
was comparable to the Zairian HIV – IA isolate and seem to be comparable to
HTLV – I and Human T-cell lymphoma and Leukemia viruses,* and “Also known as
lymphotropic viruses, these retroviruses are not lentiviruses but oncoviruses.
They seldom cause disease or meet HIV in the same cell but are prospective HIV
partners for production of recombinants. In monkeys they are STLV – I and II.”
But according to Deusberg (2003), in 1985; Gallo changed the
name in 1985….for the human T-cell leukemia virus – substituted it for human
T-cell lymphotropic virus meaning infecting T-cells, that “A sample of the
leukemic T-cells, originally named HUT78, was sent to his lab for isolating
leukemia virus.” But Deusberg did not specify the strain of virus that Gallo
took, whether it was the one from Zaire or some district in Africa.
That they dovetail the leukemia causing cancer virus in
Cancer, means to add that their prognosis of the Feline oncogenic virus –
(virus cancer primary concerned with Cats and particularly through breathing)
is prove that the Elly Lilly and Rockefeller
Institute were familiar with the ‘…cases of ‘Feline AIDS” (FAIDS), which
are Deusberg mention was isolated as “simian immunodeficiency virus” and blamed
it for “AIDS” in monkeys (SAIDS), all of which are product of the 40’s in U.S
and in France, and then 50’s were the curtain gradually fell for the rest of
the biological scientist.
There other foundations of Biology and medicine that are
important, used in part by Peter Deusberg in his arguments against Gallo and
Montagnier that viruses capable of causing epidemic should be new viruses – set
in order of Koch – where the theory was also placed in different in terms of
(Farr) on the veracity of a New Virus capable of creating epidemic.
In short summary HIV could did not meet the criteria for a
new virus since it was always in the system and in fact no new epidemic could
arrive human being through new and direct process since all life from a nearest
beginning is part of some evolutionary pathway and therefore not new, that new
cold cases which arrive either by day or by night in human to human
environment, were not new viral cases deserving of a new category such as a
case of HIV or immune deficiency virus, which Peter Deusberg argued was not a
new cold virus and does not need doctors to defend it, that it was simply not
previously diagnosed.
This situation of great importance given the issue of
detecting a new virus and its pathology, for if we agree with Deusberg, Koch,
Farr, that there are viruses out there that has not made contact with us, that
these viruses are not new viruses and therefore not different from the cold, we
may consider disabusing our emphasis on detection and mainly detection whose
purpose is well served to the evolutionary path or pathology of the very virus.
What Deusberg argues for can mainly be understood from other
elements of immune deficiency syndrome, that the cold cases of drug induced
autoimmune deficiency were as rampart as the drug and cocktail induced 60’s as
they were in 80’s. We betray some of the perceived argument from Deusberg by
stating that there elements of disagreement in his book set against Luc
Montaigner, that attempt to place emphasis on the redoubtable origins of the
Virus – HIV – suffer a consequence given the more mature arguments which could
have emerged from his book.
One of the perceived argument is role of evolutionary
pathway of the Virus – that given the lack new definition and misdiagnosis of
HIV or any virus, there are other reasons why it could have surfaced in
specific periods on human existence – for instance during high period of human
activity, air pollution, and zoonotic episodes on man and the primates.
In addition to these periods are cases of human activity,
that drugs can weaken human immune system, for instance Cortison as
demonstrated by many experts and in very recent case by Abraham Verghese, where
the introduction of Cortison shots to the body of Rat can give the rat some
induced metabolic process especially in case of the rat’s activity that the
Cortison shot end up damaging the immune system of the Rat leading to specific
cold spells detrimental from blood.
Dr O.U Orji in Nigeria have also found the use of Cortison
to have undiluted effects on human blood, the cause of this is not exactly well
known, but we can be sure, that the blood structure – especially Hemeglobin is
affected by the presence of certain chemicals – such as Cortison (steroids) –
which the body need since it widen the protein gates of the body and induces
rapid chemical and enzymic reaction leading to increased body activity and
blood flow but it ends, altering the structure of sugar complex and nucleotide
phosphates for instance Thymus, which is the weakest link in the DNA bases
plate.
Apparently all connection necessary for generating new life
and possibly creating one adapts to the thymus, which is the very important in
production of CD4 and human immune system – and cortison – no less steroid or
in many ways than one, testosterone builds as well weak the human elective
immune system – especially the male.
Taken differently, drugs and drug induced energy products including for
instance Gensing is considered a blood thinner for reasons of its reserved
ability to delay the oxidation process and the role of sugar necessary to stay
oxygen in the blood since the body because of valium do not retain oxygen for
long hence we are tired for reasons of life.
Blood damage can occur naturally and like cancer can occur
due to genes borrowed from parents, but in terms of artificial breakdown of the
human blood and the defense mechanism, it is prolong exposure of the body to
damages of all types that induce poor repair strategy for thymus leading to
weak and vulnerable immune system no different from HIV.
While we may indicate that the whole statement raised by
these experts are true, they are true to the extent that the body could easily
adjust to changes in the body and in the environment if and when the exposure
to the system does no prove fatal. It is taken that these viruses capable of
destroying the body in slow or speed motive are doing so for many reasons
including that the body and CD4 cannot keep up.
However there is no going that HIV is an infectious disease
in keeping to Deusberg and in Order of Farrs - HIV viruses do not meet the
criteria for infection, adding that the virus is considered a retrovirus
essentially to the careers of Gallo, Baltimore, and Montaigne, whereas
retrovirus and the reverse transcription of RNA to DNA and DNA to RNA though an
enzyme, means that HIV could have been the reasons for AIDS as according to
Deusberg, but in all, shows that the total damage that the body can sustain is
sufficient to satisfy its healing and its cure so long the exposure does not
directly and indirectly kill the system composed mainly of active cells. But he
is wrong about the dual undeserving dual purpose of HIV, for it to be
considered a fallacy; there is something about the changes in human body that
accompanies the changes in one’s genetic component.
I shall doubt that
HIV lead to AIDS under all circumstances, that some are by nature predisposed
to autoimmune diseases and have problem of weak immune system making vulnerable
to serious and challenging which like cases such as HIV in stages from virions
suffer the victim to ends as end becomes those with compromised immune system
open to extreme cold.
In comparative analysis on all that is well discussed and
well-rehearsed about human immune system, it is not HIV a virus and study by
itself that kills the victim, it is the weakness of the immune system resulting
from weak and depraved blood structure and oxygen – cortisone and thymus – that
leads to leads to the premature break-up of A helical structure of the blood
(Hemoglobin) which is well studied by Linus Pauling and Max Delbruik,
Salvatore, leading to the crystalized structure of human DNA and body, and the
intellectual history show how the body link the chemicals together in what they
call Chemical Bonding and the DNA dogma defined by Watson and Crick in 1953.
David Suzuki and Peter Knudtson… studies in metabolic
deficiencies such as Lesch-Nyhan me….Amniocentesis – performed during 14th and
16th weeks of pregnancy, the presence for example, “…the red blood cells of
people born with a hereditary illness called glucose-6-phosphate dehydrogenase
(6-6-PD) deficiency – a disproportionate number of whom happen to be members of
racial or ethnic minorities – are thought to be more susceptible to damage from
oxygen depletion during prolonged exposure to naphthalene and other industrial
chemicals than are the red blood cells of other people.”
The gene therapy for sickle-cell anemia would involve
inserting copies of the desired DNA sequence into ‘living bone marrow cells’ in
other to perform a desired function…and the basic steps for gene therapy which
is has a lot of promising career is that it helps to welter down the sudden
presence of oncogene in the blood and the blood cells. It is through the amplified focus of gene and
blood padding, which gives the body a kind of immune defense without
necessarily resorting to the body and the cells in the system to fight the
onset of HIV and its attempt at penetrating the cells from where it begins to
immortalize.
One of the instruments applied is the knowledge application
of the knowledge that a single gene resident in Red Blood cells (Hemoglobin)
was responsible for sickle anemia. This argument was made especially clear
Linus Pauling and his group of scientists, does not differ from the role of
genes leading to the damage of an enzyme in the body, which Joshua Lederberg
made very clear.
This gene therapy therefore makes its seem obvious that the
comparative association of the gene replacement in direct auto-immune cases
such anemia and sickle cells, can be applied to HIV since the breakdown of the
body begins from the attachment of the Virus to the human immune system.
Without the defense system that circulates the surface of
the cells, there is a possibility that the body could withstand HIV or similar
virus except that the condition which is not far from the Hemophiliac, could
essentially suffocate the virions which entered the body. Although the rapid
cells division of the Virus suggests it may be not be possible, it is however
reasonable that the earlier a victim begins a treatment the better. Gene
therapy is not sufficient enough in nestling the problem of HIV.
Heterozygous sickle cell traits from both partners may
warrant their children stand 25% chance of having homozygous sickle cell anemia
would involve inserting copies….the desired DNA. Bone marrow cells are the
source of a patient’s genetically defective red blood cells…..“….cancerous
blood-forming cells in a patient suffering from Leukemia, for example, are
replaced with cells from a healthy, tissue matched donor….”Gene therapy for
sickle-cell anemia would involve inserting copies….the desired DNA sequences
into ‘living bone marrow cells’ in other to perform a desired function…..
The basic steps in gene Therapy for sickle cell Anemia…..
Oncogene sudden change…
Vulnerable to untimely collapse each time blood oxygen
levels decrease….The genetic Basis of sickle-cell Anemia, it affects the
production of one genetic pool for identical normal hemoglobin, sickle cells –
and low (blood) red blood cells…
Linus Pauling – and his group demonstrated a ‘single
molecule’ defect resident in Red Blood cells hemoglobin was responsible for
sickle-cell anemia. To demonstrate this as they placed Hemoglobin proteins in a
gelatinous substance and exposing it to weak electrical current
(electrophoresis) which demonstrates the chemically based difference between
two separated. What they also discovered
is that when the valine which is an Amino acid is turned off with glutamic
acid, it directly alters the shape of the hemoglobin which is usually three
dimensional given the arrangement of the Amino Acid.
When the mutant S hemoglobin (Red Blood cells) encounters
low oxygen blood concentration, the hemoglobin becomes erratic in a bid to form
its own crystal structure and ends forming a structure that is quite different
from the three dimensional regular Amino Acid. The result is that the structure
based loosely on a fractured composition causes the cells to collapse. In essence
the sickle cell after a while is returns or re-encounters an oxygen rich part
of the cells and circulatory system, these formative molecules break-up, which
is on contact with oxygen-rich blood, allowing the red blood to return to its
regular shape…
One of the more contentious of this period which lends
itself to Enders in some level, it is the charismatic clarity of Chemical
bonding at the level of human blood and hemoglobin and how the permeation of
Sickle Cells and other blood cancers were undeserved death sentences.
Where certain chemicals can induce the worst human
reactions, that they can damage the crystal structure of any blood leading to
premature explosion of the walls, it is well studied that the real reasons
behind the poor regulation of the oxygen in the blood or in some cases, poor
regulation of sugar in the blood resulting to a different pancreatic cancer
called Diabetes, Sickle cells enfeebles the victim by squeezing the consumption
of rate and hence the duplicity of red blood cells in the human body, whose
primary role as a b complex is to condition the profligate activity of the
white blood cells primary thymus depended.
You are no longer in control of your senses when the red
blood count decreases and panic and headache no less different from advanced types
of diabetes send the patient various ends of pain and aneurysm and the body
demands its shots. It is the lacks of red bloods and high dose of white cells
that signals the beginning of the age of new infection in the body.
These are side effects which medicine over the course of the
last 30 years has helped to undress but the main events of the HIV is what
happen to the blood and the rest of body – especially the spleen which a
personal theory – leads away from the old into the new and back to the old that
the HIV is a virus that induce various forms of blood cancer, that it means the
body progressively vulnerable to invasion, that we thin out due to the role of
the virus and we die gradually and grudgingly from AIDS since the body is no
longer at ease with blood stimulus – hence poor production of red blood
cells……..
That in limelight of those who discovered the oncogene
viruses or isolated it from the strain of a cancer causing virus, it was
achieved in 1951 at Rockefeller Institute from possibly a strain of the Congo
virus. It means that the dives on Gallo’s HIV buffs, is probably not new, may
started as a trial in the context of the
theories about Viruses and primitive parts of Africa.
If we are to break it down, it almost seem to point out the
that strain of Gallo’s virus that was available for processing and was
available for early consumptive laboratory work was from a strain of the virus
from Zaire, that it may have a common physiology with the strain of those of
the Norwegian sailor, even in his estimate the man was no longer available.
By
Sampson I.M Onwuka
The Chapter was destined to be written and the final
solution begins from where we started….
There is something about the Medical Institutions and the
Act of medical discoveries that can plunge an entire world of information into
some abyss until perhaps redemption. All the breakthroughs in science and
technology need not be rehearsed as a consequence of these long years of
experiment and studies, leading to disasters of all types and sometimes with
some degree of consequence. One man whose theory concerning the problems of
perpetual error and why institutions carry on with these mistakes is Joseph
Greenberg in his dissertations about language and human dispersion theory,
theories well evident by the Luigi Cavalli-Sforza. Mistakes can be conceived by
any number of institutions and can be transferred from one form to another and
until a breakthrough; it survives some of the assumptions in business and
elsewhere. The advent of HIV at least in the least in the last 35 years is no
different from this kind of problem, especially those of Polio which has given
us all the headache known to us.
That a thing and perhaps a sickness such as paralyses from
Polio eluded the frontiers of sciences for at least 40 years in spite of the
breakthrough by the Karl Landsteiner on A, B, O on the bone marrow and the
brilliance of a certain Jewish immigrant by name Simon Flexner who for his sake
and for the need of medical research that they developed the Rockefeller
Institute in New York. These men including those took umbrage under his
leadership, (1) Herald Cox (2) Max Theiler (3) Isabel Morgan (4) Thomas Francis
(5) Tom Rivers (6) Peter Olitsky (7) Albert Sabin, names very familiar with us
in Virology and the culture, and like in many open sources these are champions
of medicine for many years in vaccination and early attempts stem cell
research. The book that throws some light on the history of these few including
the familiar Max Theiler who succeeded in growing a Virus in the brain of mouse
is called Polio; An American Story, by David M. Oshinsky (05), we should be
able to quote from this book, at least in gainsaying on some of the assumptions
about the connection between Polio and HIV, where the author made some medical
blunders no more than the ones that Merck made about the unknown dynamics of
the human immune system.
But in Oshinky’s ‘Polio’ story we are privy to his citations
describing an important figure in fight of Polio by name Karl Landsteiner that
“At his Laboratory in Vienna, Landsteiner produced an emulsion from the Spinal
cord of a boy who just died of Polio. He passed the liquid through a porcelain
filter, injected the contents into the stomach of two rhesus monkeys, and
waited to observe the result. It didn’t take long; the monkeys proved to be
wonderfully susceptible hosts. Both succumbed to Polio, their spinal cords
showing much the same damage that had occurred in the little boy. The Polio
virus had been isolated.” The process of extracting a virus would in future be
that complicated but they follow the same process, yet the intentions behind
rendering the piece in spite of the Polio is taint the discourse with the bone
marrow incident regarding the treatment of immune deficiency syndrome that much
effort has been put in to help the victims of the AIDS whose bodies are racked
by the virus by chemotherapy in removing much of the bloods in the spleen and
bone marrow of the affected areas or areas of interest, and using a foreign
entity and bone marrow try to restore the blood of the patient in a process
that is similar to cancer treatment yet they get worse and worse. The point
that HIV is at least for now a blood borne Virus does not
If the virus is fed through the mouth the victim hardly
suffers any special injuries and any specific inductive injuries but when the
Virus is fed through the nose, the reactions were very fatal. In fact the mode
of infection which are so believed as the same and similar to Tuberculosis
which infected people through the nose and breathing, cursed severe reaction in
the body of the victims particularly the monkeys, may have given some reason
that the mode of penetration of the virus was similar to other agents of the
body.
David Oshinsky writes that “No one found a way to block
poliovirus from entering the body or to neutralize it with drugs or chemicals
once it got inside” For many years the conception that the nose was how the
virus entered the body proved frustrating to scientist and in the image of
Simon Flexner who help to carry out major reforms in virology, there was hardly
anyone to challenge the basic assumptions. There was something else, apparently
the reason why the mouth feeding of the virus did not convey any particular
kind of adaptive meaning, is that the monkey used for these experiment is
called Rhesus monkey. Its ability to mount immune response depended on many
things, in part for the silaic acids which are contained in the body and are
presence in the nose and nasal cavity, exfoliates its existence and as someone
theorized, many people did not know why we couldn’t stop the virus from
entering the body. It would seem that it was only through the nose that such
penetration of the body was possible.
The story on how it was discovered that other primates
reacted differently to the virus when fed from the mouth is not clear, but the
opposition of Flexner to the use of these primates proved that it was a
well-known fact or suspected as such that a particularly kind of monkey acted
differently when the virus is fed through the mouth. The rest were victims of
the same thing. For that reason, the understanding that the route of the virus
was from the alimentary canal and not the nose or at least more than nose,
proved a damage to Flexner’s theories and became a point of rally for all
scientist. This new knowledge is so critical to further enhance the experiment
on Polio viruses that it led many scientists to shift their attention from
monkeys to chimpanzees.
Oshinsky put it kindly that “if Polio virus entered through
the mouth and worked its way down the digestive tract, then it must travel
through the blood before entering the central nervous system. If so, a vaccine
designed to raise anti-body levels in the bloodstream would be able to
neutralize the virus before serious damage was done.”
From this development, they were able after almost forty
years of the studies on Polio virus to now learn how the virus develops and
what makes it work and why the virus became a hit for the rest of the
scientific America. At least Scientists were now able to focus at (early
infection) and the blood stream was the place. In the words of John Paul, “It
meant that small amount of virus which invaded the blood could probably be
overcome by relatively small amounts of circulating anti-body, and by this
means could be blocked from gaining access to the central nervous system….At
one fell swoop, the problem of immunizing man had been rendered easier than was
expected.”
Among the first investigators to look at the virus in
previous and neglected blood samples was a certain Dorothy Horstmann, who was a
member of Yale crack Polio Unit team of invested much of her time in looking at
blood of the victims that came into the hospital from the 1943. A basic line
should include David Bodian and his group; she was not the first or the only
one that looked at the blood of the victims that were infected by the Polio
virus. And the blood became very central to the point of demonstrating from the
stored blood of nine year old, that unless the virus was not in the system and
in the body already, there was no way of knowing unless she got sick. That it
was only on this account did any change take place in the body at all, that as
soon the blood realized that it had a disruption in its system, proteins and
folded inwards and then the attack on the nervous system which is primary to
the virus.
If fed through the mouth the virus could invade all the
stomach and reach down the body where it profligates, but majority of time and
according to several practices which are done, the virus hardly makes it into
the blood stream in large amount when induced through the mouth of some monkeys
and ended up creating paralyses leaving antibodies which has neutralized the
virus.
The whooping size of his academics raised the tempo of
suspicion towards Apes, Chimpanzees, and Monkeys as probable origins of the
Virus which eventually came in with their mutations in human and hence nearly
justified the all kinds of experiments in Congo. I must confess I have only
casually flip through the books and do not intend on writing on what clearly
obvious from his missive that the general academic consensus favors a Spillover
from Monkeys and Chimpanzee into Human beings.
Philip Alcabes (2010) Dread book that attempts to consider
what the early CDC workers attempted to achieve with HIV and how some of the
jokes about HIV did not shy from the social stigma of those who were called
freaks or in the 60’s bums, who suffered all kinds of malfunction in the body
and were essentially housed elsewhere till perhaps redemption which sometimes
arrived too late. If it is not impossible to locate this item elsewhere is
because of alternate historical account of outbreaks in City wide location,
point to breakthroughs that gave medicine a new and profound meaning. In his
chronicle on HIV he pointed to an early date made by CDC released in September
1982, that “Homosexuals or bi-sexual makes – 75%, intravenous drug abuser with
no history of homosexual activity – 13%, Haitians with neither a history of
homosexuality or intravenous drug abuse – 6%, persons with hemophilia A with no
other risk factors – 0.3%, and persons in none of the other groups – 5%.”
Whereas anyone could get the virus he argues, HIV was simply the most dreaded
thing partly for the fact that there was no cures at the time, but largely for
the social stigma that was associated with it. Many of the Black and Hispanic
in New York did not see it as very present and dangerous virus capable of
infecting black as well others, and they loathed the virus as a white-man
disease.
But before long, it was gradually shown that the virus began
as a series of carefully planned conquest over the host immune system, and
after a decade of the virus of the human it degenerates into something else.
For if Blacks were gradually gaining up to others despite
being one of the smallest groups of minority in New York in terms of new cases
on HIV, it was due to the problems of information and reaction, which do not
add to anything useful.
For Asians and Africans, they were largely hung over on the
transfer of the new virus emanating from Gay Communities in New York to other
parts of New York and elsewhere, and since they loathed these communities; they
are easily vulnerable to the viruses.
Although New York in times past may have entertained the arrival of
diseases and other infectious disorder, it has lead the fights against
dangerous diseases, against Polio and Influenza, against diseases; both
airborne and waterborne. The City is hive of visitors with long term view of
the City and travelers for other reasons and immigrant population since the
18th hundred has continued to sprawl till very recent days.
New York downtown has no particular architectural, the
immigrant populations; Irish, Italians, Jews, Africans, Caribbean, North and
Central America, and other income capable brackets were primarily concerned
with their own survival. Although the immigration continued in New York by
Europeans, it helped to form some of the assumptions about new diseases and
epidemics, to a point that it can be said that studies about the early diseases
in New York in the last 100 years or so were mostly derived from reaction to
outbreaks such as Chicken Pox (Varicella), Pertussis (Whooping Cough),
Pneumococcus, Hepatitis A, Hepatitis B, Rotavirus, Influenza, Meningococcal and
some variety of human papillomavirus. In a sense some of the assumptions about
these diseases made outsiders temporary targets for reasons of their own.
The Polio virus was one of those outbreaks where a strain
from African monkeys was very necessary in understanding the pathology of Polio
which Flexner believed was generated from stomach to the body or through
digestive tract – in essence it was ingested. Many of the experiments at the
very beginning had to with mouth feeding of some of the creatures and primates
– especially monkeys were fed through the mouth with strains of Polio virus and
the end was not to the interest of the scientist. The main point is not the
process of profligate Polio virus but on why it was necessary to ingest the
various from the beginning and why the issue of blood pathogen proved a
different and difficult point to redress. Look at it differently, when it
became very clear that the Polio passed through several processes and
especially the blood, the science committee was more than ready to handle the
Polio mellitus once and for all.
Secondly, if the mentioned virus-ridden diseases and
conditions, especially Influenza and Spanish Flu for instance of the 20th
century A.D, were considered from purely medical and biological point of view,
they show patterns of infection and host-DNA which alters the destruction of the
infection process of the virus, some produce fever others with the same viral
infection may give similar but different infection in the body. The immigration
population who make it to New York where left to places such as Randall’s
Island, New York, a place which as the repository for those dead or dying. Of
course they naturally remain quarantined saving for instances of Polio and
viral strain of its culture.
The modernity of New York as now and then appears on the
world map and its visible schools of medicine was not always the case, for at
least we can set our eyes on the formidable FDR days, whose efforts as Governor
of New York and eventually president proved a watermark for the attitude of the
public to issues of health. It would not mean that Harlem River drive heading
the F.D.R was named after for political reasons, but the combating of Polio by
forces affiliated with his office such Bob O’Connor makes the faithful date of
CDC recent as they provide the necessary tools towards the growth in health we
have seen over the years. But needs be mentioned that a lot list of all the
breakthroughs of sciences in the United States and in the world did not arrive
by idle conjecture, did not arrive by efforts of any one group such those for
instance at Rockefeller Institute which has fielded and trained more competent
and decisive virologist in the last formidable century, more than nearly all
institutions anywhere in the world.
Perhaps the Pasteur Institute of Paris or other Schools of
interest in Massachusetts; Harvard, etc., which though perform its function
along the elite schools of the country, cannot in itself expel the contribution
by other schools either directly or indirectly influenced by Rockefeller
Institute in the last century.
This will not mean that schools such as City College of New
York with as many Nobel Prize winners as Yale is to be taken away, it shows
however that the merit of open culture and attitude to this merit widens on the
even the smallest avenue of possibility that what works in one area, may not
apply in other cases. It will be useful
to point that the Cold Spring Laboratories in Long Island maintained an open
culture and relevancy of attitude to science from the days of its founding by
Watson and Company to nearly all combating of new virus which CDC is
particularly known for. That will add to the assumptions that the failures over
the years to deliver on HIV may be due to the fact that it was believed to be
disseminated through deviant sexuality and the encouraging the scorn that it
was created by God. But if half of what learnt over the years and at least in
the opening heroic search for cure at the beginning was never replaced or
transferred from one community to another, we may have in my view – purely in
my view – put a final end to the Virus.
While it is easy for me to accept that giant steps in
Medicine has failed in generating final solutions for HIV, it serves then as
well now as an example for what may have transpired between Polio Virus and the
arrival of the scientist who ended the whole sage. In areas I succeeded might
clearly interest you with the fact that I spent 2 years studying Harvard
Medicine for fun of it. And in the last returning decade and a half have spent
hours of a given day on History, Anthropology, and generally studies human
genetics. Majority of these studies show it’s relativity to HIV and the cure
for immune deficiency syndrome prove a lengthy stay for reasons of their own,
to a point that some of the conclusion vary in its results and the end point
was a question of some understanding about viruses and its evolution. This
aspect of our understanding of biology and chemistry is very important given
the very reason why vaccinations seem to have failed.
Barely a year ago, the argument about the SVO40 virus
supposedly from Chimpanzee and the Polio virus seem to have stagnated between
Chimpanzees and human immunogenic viruses, which may have resulted the strain
from Polio considered a leading item to HIV. But this argument in all its forms
had to be dealt with, perhaps decisively given the basic premise of HIV
infections and its pathology. Put it differently, there is no connection
between Polio Viruses and HIV, and there is no link between immunogenic viruses
which infect primates and humans saving the issues of the patterns of infection
and the chief cause of the agents. The example about the slow viruses and
oncogenic viruses are especially important largely for leading but misleading
line of reason about HIV and the very knowledge of viruses and immune
deficiency syndrome.
Looking backwards to some of the stories from Bronx and from
parts of White Plains, New York in the early 90’s, there is hardly anyone who
knows what the virus was all about and what its problems anywhere. It was known
to be deadly, known to remain dormant for a long time, to be conversant with
Homosexuals and with illicit drug users, where they speculated that sharing
needles was very dangerous because of the dangers of blood contamination.
Special classes are taken to handle blood and the secrets keep so tightly about
victims that even some of the workers were placed on a need to basis. On a
special basis as well, there are reference to Russia and the events of Cold
viruses, including period of long epizootic and Moritz Kaposi (Russia)
associated with description of what eventually considered Sarcoma, and pox
related virus sickness.
It will seem also that the comparison between the Lentivirus
that Montagnier is associated with is not unknown to Gallo, promotes only two
possibly arguments that Robert Gallo were looking at the comparative physiology
of the primates and the humans, their gaps in defense mechanism and whole
comparative physiognomy, that he believes in lieu of Rockefeller Institute and
their historical breakthroughs, that a similar virus if discovered in the
primates can lend a pair of eyes to those of humans.
The second reasons are that he and his group may have
believed upfront that the virus essentially came from Africa. It is only
reasonably reassuring that Interleukin-2 associated thymus which Montagnier
emphasized has its reasons, based perhaps of Claude Jasmine Chermann.
When we look at the structure of the protein from sources
totally available to us, the use and eventually the abuse of Gallo’s strain
resulting in its isolation of the human version of the Zairian Strain, is said
to be oncogenic virus, means that it is cancer causing, will also point to the
fact that over the last returning decade of the search for HIV and its cure was
sentenced to a goose chase, point must be made that the strain however
oncogenic could not connected to human cancer, though the virus when triggered
delivers according to its purpose.
Therefore a connection between the cancer virus and human
immunodeficiency virus were test that led to wrong conclusions, for if HIV in
of itself could infect monkeys, a kind zoonotic trans-infection would be
possible among the humans. Looking at the conflict in the early years between
Gallo and Montagnier, it is becomes gradually clear that Montagnier or the
house on which Montagnier is based would have collapsed, were it not for the
fact that he did specifically mention that he used the Interleukin-2 protein
induced virus to isolate the HIV virus, suggesting that he was right that the
virus called HIV or initially a LAV virus was different from Gallo’s Virus.
For the similarity and differences between Gallo and
Montagnier, it will be common sense to show that cancer is the bottom line in
whole argument, while the Gallo cancer causing virus is different from
Montagnier is perhaps due to their specific origins. Although there are other
viruses that trigger the creation of mutants, the rate at which we notice the
differences between the two scientists is what their viruses do inside the
body. HIV can be called a kind of cancer; perhaps blood cancer given the long held
observations of people with the virus and may have been the motivations behind
the use of cancer agents with direct reference to the blood.
But it is the blood that matters, what happens to the Red
Blood cells over time which ends up affecting white blood cells or CD4 counts
over time. A dip in the CD4 counts eventually comprises the body’s defense
systems. We are now certain that AIDS patients die from Opportunistic Infection
(OI) and not from HIV itself. Looking at the history of HIV from these schools
will arm with some basic understanding on why emphasis on thymine very central
towards the survival of the patient, and why most efforts in correcting the
reverse transcriptase did not perhaps lead to any new grounds.
Here it will be rewarding to show that mycobacteria is not a
new name in the market, it is has been and for many scientist for instance Lynn
Marguilis and her colleague Dorian Sagan, have given some academic devotion to
the transformation that take place in the life of a bacteria and how these
mutational changes, from one area of the chromosomal to another adds meaning to
what is now called Epigenesist which..., and which Adesinine and Guanine based
protein building on a three level phosphorylation within the cell and through
diacyglecrol perform separate respiratory function relative to the ions of the
surface, where a short and misconceived attraction and relapse duration(cell
respiratory on the Golgi body) can affect the false release of information and
trigger event reaction from the cell are based on some role of oxygen. If we
recall briefly the experiments of Oswald Avery on pneumococcus, there is an
express that he defined about Deoxyribonase Nucleic Acid (deoxyribonucleic
acid) there he emphasized thymine as operand towards the creation of new DNA.
some multi-celled organism living in the gut of say Cow or
in its intestines, which are naturally used for the reproductive processes of a
milk (bi-product) are not normally known to be destructive, may remain friendly
in the gut and intestines of the Cow or other mammals until the frequency of
the cells or immunogenic is comprised….It is these two viruses that are equally
significant in the defenses and failures for and against HLTV virus which are
generally oncogenic such as the ras and abl and to some arguable degree yes
genes in blood and pneumonia related cases can be represented as viruses
received from several range from bare-back viruses such as mycobacterium,
particularly Avian which is a Sars virus which is respiratory based virus and
in like viruses or multi-cellular organism and their viruses….
Flossie Wang-Staal researched with great success of the
structure of HIV, and it was the knowledge of the transcription factors acting
on the HIV, especially in the introns and enhancers, the terminations point of
the Amino sequencing that provided the base-board for developing AZT, which
implies the phosphate roles of thymine and was set then without knowing against
a alu genes. The marking in terms of the transcription factor largely because
HIV is replicated at the right of the LTR, but seem by its transcriptase to
have perhaps started its origins at the left of LTR.
That it is no use and cannot really affect humans as such
the placement of the virus at whatever angle and its conjugation to the nearest
human cell which replicates at the right of LTR as with Amino Acid, prove to be
well meaning for a healthy life of a cell, but this key location could also
transduce a mutation leading to cancerous edifies or creation of mutants. This
in-of itself can induce cancer causing deficiency in human beings and has means
and ways of expressing itself in
human beings as primates – with or
without due respect to the Alu genes.
For all intended
reasons we presuppose the methyl alu genes is a jumping genes that is not
insubordinate to mutations, and should be classified as mutagenic. Alu genes
are relatively twisted does not mean they are retrovirus or retrograde, but
there are reasons why these twist, they reveal a different version of the
genetic DNA especially among Africa Blacks. It is suggested that this is part
of their evolutionary past is prove to the causal link between the past Great
Apes and the present but these are alu are not formed in the Great Apes and not
prions or dangerous
The man who whose theory on defective proteins and prions,
whose work transformed our knowledge of prions is Stanley Prusiner. Whether the
constipation of the alu genes or the jumping genes that confirms Stanley
Prusiner (U.S) long lived Noble Prize on Prions as infectious proteins, we are
clear that infectious proteins are mutagenic and does not inspire a
transformation from one form to another, a saturated argument anyone can make
saving for the vast implications in phage studies.
For sure if in more
recent times, that Arjit Varik and Elaine Muchmore in trying to adapt a new
drug to enzymes working to oppress the profligate of HIV did not award much
help, there is then something wrong in the process, a misleading grasps of the
fundamentals of molecular biology or in recent times, RNA sciences. “By 1998
Varki knew why we were peculiar; a 92-letter sequence was missing from a gene
called CMAH on Chromosome 6 in human beings, a gene that codes for the enzyme
that makes GC.” ‘Right in the middle of the
sequence was an Alu genes = ‘Jumping genes.
“So sometime after the divergence of the human and chimp lineage, this
Alu had done what it does best, which is to jump into the CMAH gene, swap
places with the older Alu, and accidently remove the 92-letter chunk of the
gene while it was about it”
‘Throwing stitches’ using his exert quotations, Matt Ridley
stated that the “Hox genes are the recipes for proteins called “transcription
factors”, which means that their job is to “switch on” other genes. A
transcription factor works by attaching itself to a region of DNA called a
‘promoter’, where IGF2R gene on Chromosome 6 ‘Premature damage to the brain or
late development…
AZT as described by many experts is cell mediated immune
response where AZT is incorporated into the host cells, DNA, and as Irwin
Sherman suggested it is shown to be introduced in some numbers in the DNA which
is set to clarify what Peter Deusberg mentioned that it actually tampers with
your human DNA, whereas the Factor VIII mentioned by Deusberg is not exactly
anomalous may prove to be relevant to Hemophiliacs…..
On AZT a ground breaking theory, we have noticed the work of
other experts such as M. D Grmek (1990; translated by Russell Maulitz, Jacalyn
Duffin), that points out the evolution of the disease in six hierarchical
stages and according to the maturation of its protein, which for the author
reflected “the chorological and biological status of infection…” and it is A,
T, G, and C, that make up DNA…..3-azido-3’-deoxythymidine – or AZT…., the
Antigen-presenting cells and whose Human leukocytes, Storm trooper T cells
antigen (HLA), Viral antigen, T-cell receptor (TCR) and in one major combination shift from basic complex to
defense mechanism – more like the age of protein, with age protein perform
different function in human body.
Dani Bolognesi, the whole structure of HIV protein fell,
with one particular emphasis of the gp120 envelope glycoprotein. This gp 120
proved a deciding mark in the renewed assault on HIV sometime in 80’s and it
revealed considerable presence of what he called ‘main proteins’ (P24/25 inside
of the protein box, and gp120 and gp41-43 outside) whereas some of the proteins
are well to share comparative similarity with sooty mangab1ey (cercocebus atys)
which carried a strain of the virus (STLV – IIIsmm) inside.
In relation to these strain of viruses, there are
lengthy….Grmek as one the foundation members of the war against HIV mentioned
understanding the cleavage enzyme that was delayed in the orchestration of the
CD4, and the primary.
Daniel Bolognesi continued that ‘To this end, biological
modifiers of the T-lymphocytes, such as interleukin-2(IL-2), hormones derived
from the thymus gland, or thymomimetic drugs (DTC, commercial name imnthiol),
were tried, as well as transfusion of HLA-matched lymphocytes or even bone
marrow transplantation.” Emphasis – even
after some decades on HIV is thymomimetic drugs which sometimes prove poisonous
given its
“The first of these products autoimoniotung state or HPA –
23 (so named because it was the twenty – third heteropolyanion synthesized by
chemist Gilbert Herve and Andre’ Teze), was known ever since 1974 work of
Claude Jasmine Chermann as an inhibitor of reverse transcriptase in the
retrovirus responsible for murine leukemia and sarcoma. Chermann studied its action
on the AIDS virus. HPA -23 inhibited the activity of LAV reverse transcriptase
in vitro.” And for this breakthrough studying the reverse transcriptase is
greatly advanced, has dominated a lot of studies in this respect excluding gene
therapy in very recent terms.
The impact of HPA 23 in reversing elemental LTR Amino
replication center including the P. 53 for cancer with respect of the age of
the cells (telomeres) never papered as accurately as the promise of reversing
the reverse transcriptase of probably trapped bacteria prophage in the evolving
chromosomal based (HIV) Viral RNA. The understanding that genes sometimes trip
the activity of Amino acids is a well-established and grounded biological
induction, especially manifest in the attempt of showing the physical-chemical
properties of cells and their lopes which on the surface are controlled by the
transport of energy information and by default oxygen.
Although the uracil (urea) is the set aside as the element
that it responsible for the beginning of the process of all biosynthesis with
look-alike bases comparable to phosphate-methyl 5, most common of which is
thymine, it is for this that elements containing uracil with the 5th position
as bromo-uracil usually translate in the second stages of the sugar complexes
wrong information, since the mutant protein or bacteria that break them the
coupling polysaccharide is turned off or at least considered mutant, and
therefore cannot profligate at the essence of enzymes that dissolves sugar
complexes.
This alone along with
activities that result from the excess lysogenic activity does affect the
replication of Amino Acids, may help in editing some of the information between
RNA and DNA, may repay false RNA to RNA, but may not probably trip the genetic
activity resulting from the rest of body but eventually affecting HPA 23. In
essence, this attempt by Chermann to inhibit the profligate of the VIRUS
through arresting the activity of the binding reverse transcriptase, may
involve the artificial introduction of thymine – which essentially aids the
cells to control the activity of dictated foreign antigen.
Michael Bishop and Harold Varmus discovered that
“virus-encoded oncogenes originate in eukaryotic cells.” But it will be the
Gallo team that will make the better of this theory, and if in the decision
which lend meaning to how some of the theories of oncogenes that dominated the
early and later stages of Baltimore is placed on the same context as Gallo as
he presented some of his assumptions.
That “The HIV dissidents could see two fundamental problems;
HIV was a retrovirus, meaning it should not kill the cells it infected, and the
virus could barely be detected even in late-stage AIDS patients”, Deusberg
(2003) which threw its own light in the context of well understood realities of
the Virus and why it remains part of the human body in spite of the drugs released
to deal with it…..
Although Deusberg and company need to place some faith in
the assumptions raised by the two leading schools of Gallo and Montagnier, the
later holds more promise but Gallo may have struck an ideal comparative between
the operational dynamics of a leukemia virus – perhaps in the discipleship of
Stanley …..and his prions which are destructive proteins which also have
origins somewhere else, and still for reasons not exactly clear is short of the
right stuff in fishing the left and right of HIV when the CCR5 is knocked out
in experimental relocations of the…..
In the event that some worrying castigations on the number
of failed vaccines – at least well-meaning 20 vaccines - can be left to the
primitive carousal of a CD4 protein inhibitor by name nef so named by the
company that identified the proteins which HIV DNA based do not produce, it may
not escape our mind that the intrepid connection between the SV…..In one
Deusberg’s exertion’s “AIDS is not a disease. Instead, the AIDS Syndrome is a
steadily growing collection of (currently) about thirty “previously known”
(old) diseases.
Surprisingly in view of their notoriety for AIDS
definitions, It is true, however, that
the incidence of AIDS diseases has increased dramatically in the 1980’s as
intravenous drug use has increased and as both the consumption of recreational
drugs used as sexual stimulants and the use of AZT as antiviral drug have
increased in male homosexuals….”, may true to a large possible extent, that the
problem of HIV viruses, as they apply to Deusberg theories, is not necessarily
the lipid bi-layer of its outer shell which duck the human cells containing
CCR5 receptor, which also promotes the second attachment between the Virus and
the ducking CCR5 from the HIV virus.
Leads to some conclusion that emphasis on the viruses on the
context of its ducking technique is only correct by some extent alone. That the
problem of the Virus is not with outer most cells, it is with core-protein of
two split Streptococcus placed some arrest by some CD4 who origin can be
buttressed by the core-protein of HIV protein structure, showing that it is
operation at a DNA viral level, would not naturally mature into adult
Streptococcus, that is splits ends RNA+ virus whose primary existence is the
B> bursar cells that is similar in composition Amino Acid from more
older cell wall controlled and depended interactive from and mononucleosis as
presorted in Cytoplasm during meiosis, that it farcically relocated in the
human cells which re-dominates the virus, controls but does not effective
destroy it. It looks that the Streptococcus is one the few capable viruses
inside a human cell that profligate by relative contrast between the Amino
Cells,
David Suzuki and Peter Knudtson on G-6-Pd and job related
anemia point to histone and the expression of Chromosomes. That “For example, a
disproportionate number of sperm cells of male workers exposed to an individual
chemical called 1, 2 – dibromo-3-chloropropane (DBCP), known to cause sterility
in men, have an extra Y chromosome resulting from nondisjunction during
meiosis…”
Y chromosomes are not easily digested would look the part of
interpreting the dysfunction of a mutant protein as similar in composition to
the Y sperms reintroduced into the body. It is not exact the case but the
extent that somewhere in the ‘code-script’ used crudely by Schrodinger in
showing that the full structure of human body are products of a system that
essentially repeats on its scripts or forms, that over time, the smallest
conspicuous elements retaining these code-scripts or what we call DNA,
essentially give rise to a super structure. It is true that the smallest pieces
of human body may retain the DNA that provides its own history. But there is a
different between a DNA and RNA in such category as that we relate the ability
of a bacteria or multi-celled organism to retain its DNA is based in large part
on its ability to retain its Chromosomes in the body of its host.
There are several blood types and measures in medical
sciences that require the transplantation of one body to another, for instance
the transfer of lungs from one body form to another, requires correlation to
blood types to the extent that one’s immunology can react to the plasma used
during transplantation. But this relative reaction of the body to new
substances leading to Cancer and auto-immune reaction do not in reality affect
the body’s DNA composition.
The same cannot be sued of the bacteria or a multi-celled
organism or in some case Viruses. Bacteria can affect our Chromosomal
inheritance by being parceled to the next generation following its injury to
the gene. To the point that a genetic material passed from the parents to
offspring may have resulted from an injury inflicted on it by the latency of
some organism. In reality, there is possibilities of replacement of the
affected or damages genes after mitosis when there are more than a spare of
healthy genetic pool, but some combination between the two parents does not
have any spare to replace it and the damage to genes is carried over to the
next generation. It is not also what blood can deliver, some of the blood
treatment are realized means of temporarily healing the body, some blood
transfusion – the best blood ; the high density – are used for temporary
treatment and are eventually replaced by reproductive ability of the host body.
As such a continued injection of blood for some sickle
celled, or those with familiar and unfamiliar blood conditions, may only
temporarily offer relief of such conditions to any race or to an individual. In
the end, the host reproduces its own blood and means. Arbitrary means such as
Iron based immunogenic (which helps to manage the transportation of oxygen in the
blood, necessary for prolonging the life of HIV patient due in part to the
diminishing thymine or T-cells whose roles are intertwined with interleukin
separate from Glycerin (visna) and Serine (bovine) lentiviruses, all of which
result a diminishing of blood sugar; galactatosade base, lactose, and improper
release of oxygen leading to collapse of cells walls hence a deficiency of
oxygen bearing hemoglobin and an onset of auto-immune failure from a faulty and
pre-packaged three-dimensional Red blood Cells which drives the body’s
reproductive and immune based ability, whose profligate ensures the survival of
the plasma; the engine of life) and sugar based complexes (enzymes) such as
Insulin, are temporary but like temporary relief such as AZT for diagnosed HIV
conditions, may temporarily faux with the DNA of the host and when overdose may
prove toxic to the body.
We consider that instance some families with long list of
genetic diseases, may carry this genes from one generation to another if they
continue to propagate their offspring along same and similar genetic pool. It
is with marriage from outside a lineage can they body biologically alter the
inheritance. It all probability, there is nothing to ensure that a survival is
constant than the attempt to expand the genetic pool of the reproductive organ.
To some extent, we may consider that biological conditions are derived from
lack of fresh genetic pooling, to the point that many African Americans for
instance marrying outside their race may attract a lower and lighter density
genes, which may not support their natural sugar production.
Plainly speaking, there is a great problem of diabetes
largely from off and on interaction between their high density genes and lower
density genes, and when there are obvious cases of high artificial and starch
consumption. However, a continued emphasis on a small genetic pool or say
lineage who have reached maximum propagation of genetic material leading of a
reform of color bases and yellowish appetizing from dermis countering
epidermis, may force some of the gene pool from its bearers to retain its
damages due to lack of alternate replacement – for instance sickle cell among a
variety of the blacks and particular among Africans (Igbos, Bini, Ethiopians,
Egyptians, Cameroonians, etc) – may be transferred to a new generation without
problems.
But majority of these sickle-cells problems with die a
natural death should these group or family with such history marry a few
degrees from their core. African tribe such as Igbo to African tribe Yoruba is
an excellence example. For some changes in life to become permanent, it is
biological science that it should passage through reproductive processes. Does
not mean that it applies to all proteins and enzymes especially when they
appear as a side-effect from a disease bearing bacteria or virus. For us to
place some hope on why the male is perhaps responsible for the birth of the new
virus, a more difficult but somewhat intelligible assertion using the operon in
E. Coli experiments mastered over 40 years by the America phage group beginning
with Luria and Delbruck but essentially clarified in the long experiments of
Monod, that between the repressor bacteria and operon, it’s the transfer of
material information from one bacteria male E.Coli to a female E.Coli, whereas
the reducer (needing less oxygen; the female) is the one that carries on the
replication.
From this easy angle,
a cheap interpretation is wholly important is that seems that the discoveries
of Stahl and Messelsn’s of the impossibility of Phosphate sugar without oxygen,
seem to play that the male bacteria used oxygen its resolution of sugar
complexes and in the process enable to consummate on the female. All properties regarding this transfer of
material benefit results on a seeming and possible ending of a process, yet it
does not mean that the male bacteria dies, it means that oxygen not unlike the
processes involved in addition or removal of oxygen in human bio-synthesis by
the ribose Sugar (Deoxy-ribose) is grounds enough for new DNA replication. But
it is close since the only process a bacteria can make a DNA is through the
reproductive processes trapping and using oxygen and through the use of a
thymine based element and probably uracil.
The ability of the body to compensate on this F-factor by
the sitting or ducking bacteria is due to the host’s or cell’s ability to
regulate the profligate activity of the RNA. It is here all too clear, that
majority of the disease based immortalized cells which are able to reproduce on
their own, began with the F-factor processes, that it needs be said that
replication is female as the inception in complete and profligate which
occasional leads to high propensity, to a false attachment and re-awakening of the
dormant viruses and bacteria is to some extent male–ridden and may regarded as
RNA+. All viruses and bacteria capable of infecting the body are usually RNA+,
due in most cases on the truancy of a foreign cell which finds mating capacity
in the body of the host and its B-cells (bursar) and which penetrates the cell
of the host by ducking its surface using the glycol-protein which link on the
present angle of the virus’s cell protein to the host cells and which in the
circumstance is permitted to either penetrate the cell through in many cases
the link on the CD4 (T-4) and are essentially destroyed by the cell on
copulation with sugar and thymus derived T-cells within the surface of the host
cell or as they enter the cell’s nucleus with their foreign DNA.
The HIV virus is proven capable of evading not only the host
cells which it interrupts leading to early signs Symptoms of the viruses
including Nausea, rashes, headaches, Kaposi Sacoma, which we would have learned
by now, are the bi-product of a profligate Candidiasis from a depression
involving a growth controlling factor such as other fungi or bacteria and in
the case of Candidiasis – Streptococcus. That the latency of the Dormant
viruses and bacteria after inception or ducking usually gives way in the holy
communion of old virus entering the cell’s nucleus but with a foreign DNA –
which is a not a entre-pot for any DNA material, for there the human DNA is
reassembled and when a virus or bacteria bearing its own DNA permeate these
cell’s complex they lead to a new form of infection.
But the latency passes and when more help is given to the
body either through medication of chemical based replaced such as drugs
(immunogenic) or through the natural support to t-cells and the body to fight
the virus, the viruses and bacteria gradually diminishes its role as the
b-cells gradually assimilate the basic elements of the once latent virus as
part of the body’s immunologic; its vaccination or antibody proof. But in HIV,
we are looking at the secondary phase of its activity, that when it reaches the
human cells, it has already landed its own protective DNA from human beings
itself and therefore predating the slicing by the cell. It is concealed and
sent on its way by the human cells as part of the body yet it breeds and leads
as a mutant in garment of new cell. It my theory that the expansion of the
virus in the cells, that increases its demand on thymus by breaking the major
sugar complex such as ‘lactose, b-galactosidase’ that aid the B-cells
essentially leads to a collapse of immune system or the production of thymine
and hence a replacement in medical exception by AZT.
Mario R. Capechi, Oliver Smithies (U.S) and Sir Martin J.
Evens, 2007 were honored with Nobel Prize for Medicine in ‘Embryonic Stem
Cells’ towards specific gene modifications, experimental models using knockout muse is proven important to help
modify cells in the body. There are over 200 types of cells are altered in
protean environment and ESC ‘embryonic stem cells’ – the matrix of the changes
that take place after fertilization. It is during the fertilization that molecules
carried over from a different parent are passed to the next generation. Above,
it should be clearly stated that the first reproductive process in the life of
all humans took place in the male testis and no elsewhere else. Using basic
theme of these organizer theory, it means well if we can show that viruses at a
very small unit compose as much functional life as the highest of creatures in
terms of activity of neurons.
The work of these scientist and genetic engineering
students, reminds me of enzymes in human body, especially the ‘releaser’
enzymes which modulates over a wide range of operational behaviors in the body.
Some of operational changes are so common that it is very clear that any
changes take place in the structure of an organism is due to the function of a
particular enzyme. This also brings up the issue of stem cells and how they
apply in deciding the particulars of tissue development, hence encourage its
function through types.
Messenger RNA (Ribonucleic Acid) is for instance, a kind of
the Nucleic Acid that sends all forms of information to Protein DNA, which
trigger all forms of building protein in the course of human development, may continue
to perform its function, leading to further development of protein due to the
information received by the RNA and then the storage capacity of the Muscles
and proteins becomes a very different matter. Why the issue of muscle
development in Blacks specie or necessarily race, is due to the translation of
excess or unused calories stored in the body of blacks, led to enhance bone
formation or bigger bones and muscles, it is the quality of the protein of
these Blacks, determined by the density of genes within their alleles which
allows the DNA coding to continue, or at least break down at a very slower rate
than others. The process of the translation of calories, and information is
called Phosphorylation, where one deposit of genetic materials helps to develop
the Muscles and Bones through series of ‘catabolic’ processes. It is this
ability to store substantial information in the body in the many of the people
and in the culture of the world that now dovetails much in the projection of
the brain, with particular reference to speech and language.
But we take from their years of biological study of nature
several fundamental facts, one, there is a great world of ours that involve the
planet and which can essentially support itself and therefore constitute
biosphere. There is what we can call ecosystem which is largely comprised of
several species, involve several geographical locations such as the land next
perhaps to a sea and so on to a hill, then perhaps a savanna grass land, all
within reach of a specie and so on involves to some degree an ecosystem.
Where the support of life is buttressed by assorted types of
specie seeking to survive their given environment, under perhaps a certain
limited number of sources and interaction made possible, is regarded by
biologist and experts as a community. What we can also indicate is that these
ecosystems are not one but several groups of specie, but what is very important
is the nature of the ‘community’ of specie surviving in a given ecosystem, for
it seems that each human and external interference is likely to affect whatever
is considered any form of balance in inter-community relationship.
Community relationship involves different species and
animals executing their own wish for survival in a given biological construct.
It involves a group, it involves a degree of interaction among the people in a
population, and it involves a living condition. The issue of population and
demographic, is so central to making of a community that a ‘population’ of
animal in biology, is the arrangement of animals or organism of the same kind
and in one geographic place. The given population of any animal is made up of
individuals called ‘organism’ and a given organism of whatever specie and kind,
is usually identified external and internal dynamics, the exoskeleton an organs,
the tissues so to speak.
Tissues are what they are, a collection of cells and cells
are systems of molecules and molecules are less reduced to units of physical
sciences and chemical arrangement. So molecular biology is one area that
summarizes the systems of classification and the field also explains why
classification exists in biology, and why we have pecking order in the field.
This field gave way to understanding DNA structure and the new studies of human
genetic composition, Gene doping, Gene therapy, and of slicing and replacing of Genes that are
either lacking in a biological body or genes that need to be supplanted to
enabled a defense system that is outside of the body. This body has a way of protecting itself in
any condition or any circumstances, much of these circumstances are derived
from environment, as if the internal structure of any substance is similar to
its.
Claude Bernard work on the species ability to survive its
environment leads widen the conception of modern biology, that the issue of
homeostasis, which is the study of physiological homeostasis, indicating that
it has ability to survive all kinds of condition through the regulation of the
internal energy so to speak. Here we have seen the effects of Claude Bernard
(1813 – 1878) themes on ‘Milieu interior’ where the body by the age in which he
lived regulated itself through what was termed ‘Homeostasis’. This ability of
human body to regulate itself is not known science but was never considered
entirely human without foreign ingredient for that to happen, and in the words
of Bernard he states “The living body, though it has need of the surrounding
environment, is nevertheless relatively independent of it. This independence
which the organism has of its external environment derives from the fact that
in the living being, the tissues are in fact withdrawn from direct external
environment which is constituted, in particular, by the fluids in the
circulating body.” The system he alluded to may be reduced to the fluids in the
human body, some of which are pancreatic.
He is credited with pointing out that the several glands in
the human body – though capable of existing on its own – may be affected with
the more trying problems of temperature in the body of the organism to a point
that its ability to secret liquids or enzymes towards a fully functioning body,
is seriously dependent of what other organs of the body is doing. An example of
this kind internal regulation is the direct ability to preserve batches of E.
Coli bacteria under 37 C temperature. The timeless work of Joshua Lederberg on
the responses of the E Coli to Sugar and the survival of the E Coli in the
human earned him Nobel Prize recognition. There is hardly anything new about E
Coli but it’s representation in dealing with HIV especially the role of enzymes
and how they are prepared and easily denatured on certain exposure, perhaps why
the HIV virus itself easily denatures on contact with some forms of sunlight,
how E coli is especially predisposed to breaking up what Jacque Monod described
as ‘two headed bacteria’ or perhaps a ‘retro-virus’ bearing reverse
transcriptase, entertains the reasons why preventing the slighting of the
slighting of proteins or nucleotides and the control of these processes through
the use of protein inhibitors or protease and the relapse to reverse
transcriptase in the three cocktail has routinely occupied the minds of scientist. Identifying the cells that
control some
The Chapter was destined to be written and the final
solution begins from where we started….
There is something about the Medical Institutions and the
Act of medical discoveries that can plunge an entire world of information into
some abyss until perhaps redemption. All the breakthroughs in science and
technology need not be rehearsed as a consequence of these long years of
experiment and studies, leading to disasters of all types and sometimes with
some degree of consequence. One man whose theory concerning the problems of
perpetual error and why institutions carry on with these mistakes is Joseph
Greenberg in his dissertations about language and human dispersion theory,
theories well evident by the Luigi Cavalli-Sforza. Mistakes can be conceived by
any number of institutions and can be transferred from one form to another and
until a breakthrough; it survives some of the assumptions in business and
elsewhere. The advent of HIV at least in the least in the last 35 years is no
different from this kind of problem, especially those of Polio which has given
us all the headache known to us.
That a thing and perhaps a sickness such as paralyses from
Polio eluded the frontiers of sciences for at least 40 years in spite of the
breakthrough by the Karl Landsteiner on A, B, O on the bone marrow and the
brilliance of a certain Jewish immigrant by name Simon Flexner who for his sake
and for the need of medical research that they developed the Rockefeller
Institute in New York. These men including those took umbrage under his
leadership, (1) Herald Cox (2) Max Theiler (3) Isabel Morgan (4) Thomas Francis
(5) Tom Rivers (6) Peter Olitsky (7) Albert Sabin, names very familiar with us
in Virology and the culture, and like in many open sources these are champions
of medicine for many years in vaccination and early attempts stem cell
research. The book that throws some light on the history of these few including
the familiar Max Theiler who succeeded in growing a Virus in the brain of mouse
is called Polio; An American Story, by David M. Oshinsky (05), we should be
able to quote from this book, at least in gainsaying on some of the assumptions
about the connection between Polio and HIV, where the author made some medical
blunders no more than the ones that Merck made about the unknown dynamics of
the human immune system.
But in Oshinky’s ‘Polio’ story we are privy to his citations
describing an important figure in fight of Polio by name Karl Landsteiner that
“At his Laboratory in Vienna, Landsteiner produced an emulsion from the Spinal
cord of a boy who just died of Polio. He passed the liquid through a porcelain
filter, injected the contents into the stomach of two rhesus monkeys, and
waited to observe the result. It didn’t take long; the monkeys proved to be
wonderfully susceptible hosts. Both succumbed to Polio, their spinal cords
showing much the same damage that had occurred in the little boy. The Polio
virus had been isolated.” The process of extracting a virus would in future be
that complicated but they follow the same process, yet the intentions behind
rendering the piece in spite of the Polio is taint the discourse with the bone
marrow incident regarding the treatment of immune deficiency syndrome that much
effort has been put in to help the victims of the AIDS whose bodies are racked
by the virus by chemotherapy in removing much of the bloods in the spleen and
bone marrow of the affected areas or areas of interest, and using a foreign
entity and bone marrow try to restore the blood of the patient in a process
that is similar to cancer treatment yet they get worse and worse. The point
that HIV is at least for now a blood borne Virus does not
If the virus is fed through the mouth the victim hardly
suffers any special injuries and any specific inductive injuries but when the
Virus is fed through the nose, the reactions were very fatal. In fact the mode
of infection which are so believed as the same and similar to Tuberculosis
which infected people through the nose and breathing, cursed severe reaction in
the body of the victims particularly the monkeys, may have given some reason
that the mode of penetration of the virus was similar to other agents of the
body.
David Oshinsky writes that “No one found a way to block
poliovirus from entering the body or to neutralize it with drugs or chemicals
once it got inside” For many years the conception that the nose was how the
virus entered the body proved frustrating to scientist and in the image of
Simon Flexner who help to carry out major reforms in virology, there was hardly
anyone to challenge the basic assumptions. There was something else, apparently
the reason why the mouth feeding of the virus did not convey any particular
kind of adaptive meaning, is that the monkey used for these experiment is
called Rhesus monkey. Its ability to mount immune response depended on many
things, in part for the silaic acids which are contained in the body and are
presence in the nose and nasal cavity, exfoliates its existence and as someone
theorized, many people did not know why we couldn’t stop the virus from
entering the body. It would seem that it was only through the nose that such
penetration of the body was possible.
The story on how it was discovered that other primates
reacted differently to the virus when fed from the mouth is not clear, but the
opposition of Flexner to the use of these primates proved that it was a
well-known fact or suspected as such that a particularly kind of monkey acted
differently when the virus is fed through the mouth. The rest were victims of
the same thing. For that reason, the understanding that the route of the virus
was from the alimentary canal and not the nose or at least more than nose,
proved a damage to Flexner’s theories and became a point of rally for all
scientist. This new knowledge is so critical to further enhance the experiment
on Polio viruses that it led many scientists to shift their attention from
monkeys to chimpanzees.
Oshinsky put it kindly that “if Polio virus entered through
the mouth and worked its way down the digestive tract, then it must travel
through the blood before entering the central nervous system. If so, a vaccine
designed to raise anti-body levels in the bloodstream would be able to
neutralize the virus before serious damage was done.”
From this development, they were able after almost forty
years of the studies on Polio virus to now learn how the virus develops and
what makes it work and why the virus became a hit for the rest of the
scientific America. At least Scientists were now able to focus at (early
infection) and the blood stream was the place. In the words of John Paul, “It
meant that small amount of virus which invaded the blood could probably be
overcome by relatively small amounts of circulating anti-body, and by this
means could be blocked from gaining access to the central nervous system….At
one fell swoop, the problem of immunizing man had been rendered easier than was
expected.”
Among the first investigators to look at the virus in
previous and neglected blood samples was a certain Dorothy Horstmann, who was a
member of Yale crack Polio Unit team of invested much of her time in looking at
blood of the victims that came into the hospital from the 1943. A basic line
should include David Bodian and his group; she was not the first or the only
one that looked at the blood of the victims that were infected by the Polio
virus. And the blood became very central to the point of demonstrating from the
stored blood of nine year old, that unless the virus was not in the system and
in the body already, there was no way of knowing unless she got sick. That it
was only on this account did any change take place in the body at all, that as soon
the blood realized that it had a disruption in its system, proteins and folded
inwards and then the attack on the nervous system which is primary to the
virus.
If fed through the mouth the virus could invade all the
stomach and reach down the body where it profligates, but majority of time and
according to several practices which are done, the virus hardly makes it into
the blood stream in large amount when induced through the mouth of some monkeys
and ended up creating paralyses leaving antibodies which has neutralized the
virus. The whooping size of his academics raised the tempo of suspicion towards
Apes, Chimpanzees, and Monkeys as probable origins of the Virus which
eventually came in with their mutations in human and hence nearly justified the
all kinds of experiments in Congo. I must confess I have only casually flip
through the books and do not intend on writing on what clearly obvious from his
missive that the general academic consensus favors a Spillover from Monkeys and
Chimpanzee into Human beings.
Philip Alcabes (2010) Dread book that attempts to consider
what the early CDC workers attempted to achieve with HIV and how some of the
jokes about HIV did not shy from the social stigma of those who were called
freaks or in the 60’s bums, who suffered all kinds of malfunction in the body
and were essentially housed elsewhere till perhaps redemption which sometimes
arrived too late. If it is not impossible to locate this item elsewhere is
because of alternate historical account of outbreaks in City wide location,
point to breakthroughs that gave medicine a new and profound meaning. In his
chronicle on HIV he pointed to an early date made by CDC released in September
1982, that “Homosexuals or bi-sexual makes – 75%, intravenous drug abuser with
no history of homosexual activity – 13%, Haitians with neither a history of
homosexuality or intravenous drug abuse – 6%, persons with hemophilia A with no
other risk factors – 0.3%, and persons in none of the other groups – 5%.”
Whereas anyone could get the virus he argues, HIV was simply the most dreaded
thing partly for the fact that there was no cures at the time, but largely for
the social stigma that was associated with it. Many of the Black and Hispanic
in New York did not see it as very present and dangerous virus capable of
infecting black as well others, and they loathed the virus as a white-man
disease.
But before long, it was gradually shown that the virus began
as a series of carefully planned conquest over the host immune system, and
after a decade of the virus of the human it degenerates into something else.
For if Blacks were gradually gaining up to others despite
being one of the smallest groups of minority in New York in terms of new cases
on HIV, it was due to the problems of information and reaction, which do not
add to anything useful.
For Asians and Africans, they were largely hung over on the
transfer of the new virus emanating from Gay Communities in New York to other
parts of New York and elsewhere, and since they loathed these communities; they
are easily vulnerable to the viruses.
Although New York in times past may have entertained the arrival of
diseases and other infectious disorder, it has lead the fights against
dangerous diseases, against Polio and Influenza, against diseases; both
airborne and waterborne. The City is hive of visitors with long term view of
the City and travelers for other reasons and immigrant population since the
18th hundred has continued to sprawl till very recent days.
New York downtown has no particular architectural, the
immigrant populations; Irish, Italians, Jews, Africans, Caribbean, North and
Central America, and other income capable brackets were primarily concerned
with their own survival. Although the immigration continued in New York by
Europeans, it helped to form some of the assumptions about new diseases and
epidemics, to a point that it can be said that studies about the early diseases
in New York in the last 100 years or so were mostly derived from reaction to
outbreaks such as Chicken Pox (Varicella), Pertussis (Whooping Cough),
Pneumococcus, Hepatitis A, Hepatitis B, Rotavirus, Influenza, Meningococcal and
some variety of human papillomavirus. In a sense some of the assumptions about
these diseases made outsiders temporary targets for reasons of their own.
The Polio virus was one of those outbreaks where a strain
from African monkeys was very necessary in understanding the pathology of Polio
which Flexner believed was generated from stomach to the body or through
digestive tract – in essence it was ingested. Many of the experiments at the
very beginning had to with mouth feeding of some of the creatures and primates
– especially monkeys were fed through the mouth with strains of Polio virus and
the end was not to the interest of the scientist. The main point is not the
process of profligate Polio virus but on why it was necessary to ingest the
various from the beginning and why the issue of blood pathogen proved a
different and difficult point to redress. Look at it differently, when it
became very clear that the Polio passed through several processes and
especially the blood, the science committee was more than ready to handle the
Polio mellitus once and for all.
Secondly, if the mentioned virus-ridden diseases and
conditions, especially Influenza and Spanish Flu for instance of the 20th
century A.D, were considered from purely medical and biological point of view,
they show patterns of infection and host-DNA which alters the destruction of
the infection process of the virus, some produce fever others with the same
viral infection may give similar but different infection in the body. The
immigration population who make it to New York where left to places such as
Randall’s Island, New York, a place which as the repository for those dead or
dying. Of course they naturally remain quarantined saving for instances of
Polio and viral strain of its culture.
The modernity of New York as now and then appears on the
world map and its visible schools of medicine was not always the case, for at
least we can set our eyes on the formidable FDR days, whose efforts as Governor
of New York and eventually president proved a watermark for the attitude of the
public to issues of health. It would not mean that Harlem River drive heading
the F.D.R was named after for political reasons, but the combating of Polio by
forces affiliated with his office such Bob O’Connor makes the faithful date of
CDC recent as they provide the necessary tools towards the growth in health we
have seen over the years. But needs be mentioned that a lot list of all the
breakthroughs of sciences in the United States and in the world did not arrive
by idle conjecture, did not arrive by efforts of any one group such those for
instance at Rockefeller Institute which has fielded and trained more competent
and decisive virologist in the last formidable century, more than nearly all
institutions anywhere in the world.
Perhaps the Pasteur Institute of Paris or other Schools of
interest in Massachusetts; Harvard, etc., which though perform its function
along the elite schools of the country, cannot in itself expel the contribution
by other schools either directly or indirectly influenced by Rockefeller
Institute in the last century.
This will not mean that schools such as City College of New
York with as many Nobel Prize winners as Yale is to be taken away, it shows
however that the merit of open culture and attitude to this merit widens on the
even the smallest avenue of possibility that what works in one area, may not
apply in other cases. It will be useful
to point that the Cold Spring Laboratories in Long Island maintained an open
culture and relevancy of attitude to science from the days of its founding by
Watson and Company to nearly all combating of new virus which CDC is
particularly known for. That will add to the assumptions that the failures over
the years to deliver on HIV may be due to the fact that it was believed to be
disseminated through deviant sexuality and the encouraging the scorn that it
was created by God. But if half of what learnt over the years and at least in
the opening heroic search for cure at the beginning was never replaced or
transferred from one community to another, we may have in my view – purely in
my view – put a final end to the Virus.
While it is easy for me to accept that giant steps in
Medicine has failed in generating final solutions for HIV, it serves then as
well now as an example for what may have transpired between Polio Virus and the
arrival of the scientist who ended the whole sage. In areas I succeeded might
clearly interest you with the fact that I spent 2 years studying Harvard
Medicine for fun of it. And in the last returning decade and a half have spent
hours of a given day on History, Anthropology, and generally studies human
genetics. Majority of these studies show it’s relativity to HIV and the cure
for immune deficiency syndrome prove a lengthy stay for reasons of their own,
to a point that some of the conclusion vary in its results and the end point
was a question of some understanding about viruses and its evolution. This
aspect of our understanding of biology and chemistry is very important given
the very reason why vaccinations seem to have failed.
Barely a year ago, the argument about the SVO40 virus
supposedly from Chimpanzee and the Polio virus seem to have stagnated between
Chimpanzees and human immunogenic viruses, which may have resulted the strain
from Polio considered a leading item to HIV. But this argument in all its forms
had to be dealt with, perhaps decisively given the basic premise of HIV
infections and its pathology. Put it differently, there is no connection
between Polio Viruses and HIV, and there is no link between immunogenic viruses
which infect primates and humans saving the issues of the patterns of infection
and the chief cause of the agents. The example about the slow viruses and
oncogenic viruses are especially important largely for leading but misleading
line of reason about HIV and the very knowledge of viruses and immune
deficiency syndrome.
Looking backwards to some of the stories from Bronx and from
parts of White Plains, New York in the early 90’s, there is hardly anyone who
knows what the virus was all about and what its problems anywhere. It was known
to be deadly, known to remain dormant for a long time, to be conversant with
Homosexuals and with illicit drug users, where they speculated that sharing
needles was very dangerous because of the dangers of blood contamination.
Special classes are taken to handle blood and the secrets keep so tightly about
victims that even some of the workers were placed on a need to basis. On a
special basis as well, there are reference to Russia and the events of Cold
viruses, including period of long epizootic and Moritz Kaposi (Russia) associated
with description of what eventually considered Sarcoma, and pox related virus
sickness.
By
Sampson I.M Onwuka
It will seem also
that the comparison between the Lentivirus that Montagnier is associated with
is not unknown to Gallo, promotes only two possibly arguments that Robert Gallo
were looking at the comparative physiology of the primates and the humans,
their gaps in defense mechanism and whole comparative physiognomy, that he
believes in lieu of Rockefeller Institute and their historical breakthroughs,
that a similar virus if discovered in the primates can lend a pair of eyes to
those of humans.
The second reasons are that he and his group may have
believed upfront that the virus essentially came from Africa. It is only
reasonably reassuring that Interleukin-2 associated thymus which Montagnier
emphasized has its reasons, based perhaps of Claude Jasmine Chermann.
When we look at the structure of the protein from sources
totally available to us, the use and eventually the abuse of Gallo’s strain
resulting in its isolation of the human version of the Zairian Strain, is said
to be oncogenic virus, means that it is cancer causing, will also point to the
fact that over the last returning decade of the search for HIV and its cure was
sentenced to a goose chase, point must be made that the strain however
oncogenic could not connected to human cancer, though the virus when triggered
delivers according to its purpose.
Therefore a connection between the cancer virus and human
immunodeficiency virus were test that led to wrong conclusions, for if HIV in
of itself could infect monkeys, a kind zoonotic trans-infection would be possible
among the humans. Looking at the conflict in the early years between Gallo and
Montagnier, it is becomes gradually clear that Montagnier or the house on which
Montagnier is based would have collapsed, were it not for the fact that he did
specifically mention that he used the Interleukin-2 protein induced virus to
isolate the HIV virus, suggesting that he was right that the virus called HIV
or initially a LAV virus was different from Gallo’s Virus.
For the similarity and differences between Gallo and
Montagnier, it will be common sense to show that cancer is the bottom line in
whole argument, while the Gallo cancer causing virus is different from
Montagnier is perhaps due to their specific origins. Although there are other
viruses that trigger the creation of mutants, the rate at which we notice the
differences between the two scientists is what their viruses do inside the
body.
HIV can be called a kind of cancer; perhaps blood cancer
given the long held observations of people with the virus and may have been the
motivations behind the use of cancer agents with direct reference to the blood.
But it is the blood that matters, what happens to the Red
Blood cells over time which ends up affecting white blood cells or CD4 counts
over time. A dip in the CD4 counts eventually comprises the body’s defense
systems. We are now certain that AIDS patients die from Opportunistic Infection
(OI) and not from HIV itself. Looking at the history of HIV from these schools
will arm with some basic understanding on why emphasis on thymine very central
towards the survival of the patient, and why most efforts in correcting the
reverse transcriptase did not perhaps lead to any new grounds.
Here it will be rewarding to show that mycobacteria is not a
new name in the market, it is has been and for many scientist for instance Lynn
Marguilis and her colleague Dorian Sagan, have given some academic devotion to
the transformation that take place in the life of a bacteria and how these
mutational changes, from one area of the chromosomal to another adds meaning to
what is now called Epigenesist which..., and which Adesinine and Guanine based
protein building on a three level phosphorylation within the cell and through
diacyglecrol perform separate respiratory function relative to the ions of the
surface, where a short and misconceived attraction and relapse duration(cell
respiratory on the Golgi body) can affect the false release of information and
trigger event reaction from the cell are based on some role of oxygen.
If we recall briefly the experiments of Oswald Avery on
pneumococcus, there is an express that he defined about Deoxyribonase Nucleic
Acid (deoxyribonucleic acid) there he emphasized thymine as operand towards the
creation of new DNA.
Some multi-celled organism living in the gut of say Cow or
in its intestines, which are naturally used for the reproductive processes of a
milk (bi-product) are not normally known to be destructive, may remain friendly
in the gut and intestines of the Cow or other mammals until the frequency of
the cells or immunogenic is comprised….It is these two viruses that are equally
significant in the defenses and failures for and against HLTV virus which are
generally oncogenic such as the ras and abl and to some arguable degree yes genes
in blood and pneumonia related cases can be represented as viruses received
from several range from bare-back viruses such as mycobacterium, particularly
Avian which is a Sars virus which is respiratory based virus and in like
viruses or multi-cellular organism and their viruses….
Flossie Wang-Staal researched with great success of the
structure of HIV, and it was the knowledge of the transcription factors acting
on the HIV, especially in the introns and enhancers, the terminations point of
the Amino sequencing that provided the base-board for developing AZT, which
implies the phosphate roles of thymine and was set then without knowing against
a alu genes. The marking in terms of the transcription factor largely because
HIV is replicated at the right of the LTR, but seem by its transcriptase to
have perhaps started its origins at the left of LTR.
That it is no use and cannot really affect humans as such
the placement of the virus at whatever angle and its conjugation to the nearest
human cell which replicates at the right of LTR as with Amino Acid, prove to be
well meaning for a healthy life of a cell, but this key location could also
transduce a mutation leading to cancerous edifies or creation of mutants. This
in-of itself can induce cancer causing deficiency in human beings and has means
and ways of expressing itself in
human beings as primates – with or
without due respect to the Alu genes.
For all intended
reasons we presuppose the methyl alu genes is a jumping genes that is not
insubordinate to mutations, and should be classified as mutagenic. Alu genes
are relatively twisted does not mean they are retrovirus or retrograde, but
there are reasons why these twist, they reveal a different version of the
genetic DNA especially among Africa Blacks. It is suggested that this is part
of their evolutionary past is prove to the causal link between the past Great
Apes and the present but these are alu are not formed in the Great Apes and not
prions or dangerous.
The man who whose theory on defective proteins and prions,
whose work transformed our knowledge of prions is Stanley Prusiner. Whether the
constipation of the alu genes or the jumping genes that confirms Stanley
Prusiner (U.S) long lived Noble Prize on Prions as infectious proteins, we are
clear that infectious proteins are mutagenic and does not inspire a
transformation from one form to another, a saturated argument anyone can make
saving for the vast implications in phage studies.
For sure if in more
recent times, that Arjit Varik and Elaine Muchmore in trying to adapt a new
drug to enzymes working to oppress the profligate of HIV did not award much
help, there is then something wrong in the process, a misleading grasps of the
fundamentals of molecular biology or in recent times, RNA sciences. “By 1998
Varki knew why we were peculiar; a 92-letter sequence was missing from a gene
called CMAH on Chromosome 6 in human beings, a gene that codes for the enzyme
that makes GC.” ‘Right in the middle of
the sequence was an Alu genes = ‘Jumping genes.
“So sometime after the divergence of the human and chimp lineage, this
Alu had done what it does best, which is to jump into the CMAH gene, swap places
with the older Alu, and accidently remove the 92-letter chunk of the gene while
it was about it”
‘Throwing stitches’ using his exert quotations, Matt Ridley
stated that the “Hox genes are the recipes for proteins called “transcription
factors”, which means that their job is to “switch on” other genes. A
transcription factor works by attaching itself to a region of DNA called a
‘promoter’, where IGF2R gene on Chromosome 6 ‘Premature damage to the brain or
late development…
AZT as described by many experts is cell mediated immune
response where AZT is incorporated into the host cells, DNA, and as Irwin
Sherman suggested it is shown to be introduced in some numbers in the DNA which
is set to clarify what Peter Deusberg mentioned that it actually tampers with
your human DNA, whereas the Factor VIII mentioned by Deusberg is not exactly
anomalous may prove to be relevant to Hemophiliacs…..
On AZT a ground breaking theory, we have noticed the work of
other experts such as M. D Grmek (1990; translated by Russell Maulitz, Jacalyn
Duffin), that points out the evolution of the disease in six hierarchical
stages and according to the maturation of its protein, which for the author
reflected “the chorological and biological status of infection…” and it is A,
T, G, and C, that make up DNA…..3-azido-3’-deoxythymidine – or AZT…., the
Antigen-presenting cells and whose Human leukocytes, Storm trooper T cells
antigen (HLA), Viral antigen, T-cell receptor (TCR) and in one major combination shift from basic complex to defense
mechanism – more like the age of protein, with age protein perform different
function in human body.
Dani Bolognesi, the whole structure of HIV protein fell,
with one particular emphasis of the gp120 envelope glycoprotein. This gp 120
proved a deciding mark in the renewed assault on HIV sometime in 80’s and it
revealed considerable presence of what he called ‘main proteins’ (P24/25 inside
of the protein box, and gp120 and gp41-43 outside) whereas some of the proteins
are well to share comparative similarity with sooty mangab1ey (cercocebus atys)
which carried a strain of the virus (STLV – IIIsmm) inside.
In relation to these strain of viruses, there are
lengthy….Grmek as one the foundation members of the war against HIV mentioned
understanding the cleavage enzyme that was delayed in the orchestration of the
CD4, and the primary.
Daniel Bolognesi continued that ‘To this end, biological
modifiers of the T-lymphocytes, such as interleukin-2(IL-2), hormones derived
from the thymus gland, or thymomimetic drugs (DTC, commercial name imnthiol),
were tried, as well as transfusion of HLA-matched lymphocytes or even bone
marrow transplantation.” Emphasis – even
after some decades on HIV is thymomimetic drugs which sometimes prove poisonous
given its
“The first of these products autoimoniotung state or HPA –
23 (so named because it was the twenty – third heteropolyanion synthesized by
chemist Gilbert Herve and Andre’ Teze), was known ever since 1974 work of
Claude Jasmine Chermann as an inhibitor of reverse transcriptase in the
retrovirus responsible for murine leukemia and sarcoma. Chermann studied its
action on the AIDS virus. HPA -23 inhibited the activity of LAV reverse
transcriptase in vitro.” And for this breakthrough studying the reverse transcriptase
is greatly advanced, has dominated a lot of studies in this respect excluding
gene therapy in very recent terms.
The impact of HPA 23 in reversing elemental LTR Amino
replication center including the P. 53 for cancer with respect of the age of the
cells (telomeres) never papered as accurately as the promise of reversing the
reverse transcriptase of probably trapped bacteria prophage in the evolving
chromosomal based (HIV) Viral RNA. The understanding that genes sometimes trip
the activity of Amino acids is a well-established and grounded biological
induction, especially manifest in the attempt of showing the physical-chemical
properties of cells and their lopes which on the surface are controlled by the
transport of energy information and by default oxygen.
Although the uracil (urea) is the set aside as the element
that it responsible for the beginning of the process of all biosynthesis with
look-alike bases comparable to phosphate-methyl 5, most common of which is
thymine, it is for this that elements containing uracil with the 5th position
as bromo-uracil usually translate in the second stages of the sugar complexes
wrong information, since the mutant protein or bacteria that break them the
coupling polysaccharide is turned off or at least considered mutant, and
therefore cannot profligate at the essence of enzymes that dissolves sugar
complexes.
This alone along with
activities that result from the excess lysogenic activity does affect the
replication of Amino Acids, may help in editing some of the information between
RNA and DNA, may repay false RNA to RNA, but may not probably trip the genetic
activity resulting from the rest of body but eventually affecting HPA 23. In
essence, this attempt by Chermann to inhibit the profligate of the VIRUS through
arresting the activity of the binding reverse transcriptase, may involve the
artificial introduction of thymine – which essentially aids the cells to
control the activity of dictated foreign antigen.
Michael Bishop and Harold Varmus discovered that
“virus-encoded oncogenes originate in eukaryotic cells.” But it will be the
Gallo team that will make the better of this theory, and if in the decision
which lend meaning to how some of the theories of oncogenes that dominated the
early and later stages of Baltimore is placed on the same context as Gallo as
he presented some of his assumptions.
That “The HIV dissidents could see two fundamental problems;
HIV was a retrovirus, meaning it should not kill the cells it infected, and the
virus could barely be detected even in late-stage AIDS patients”, Deusberg
(2003) which threw its own light in the context of well understood realities of
the Virus and why it remains part of the human body in spite of the drugs
released to deal with it…..
Although Deusberg and company need to place some faith in
the assumptions raised by the two leading schools of Gallo and Montagnier, the
later holds more promise but Gallo may have struck an ideal comparative between
the operational dynamics of a leukemia virus – perhaps in the discipleship of
Stanley …..and his prions which are destructive proteins which also have
origins somewhere else, and still for reasons not exactly clear is short of the
right stuff in fishing the left and right of HIV when the CCR5 is knocked out
in experimental relocations of the…..
In the event that some worrying castigations on the number
of failed vaccines – at least well-meaning 20 vaccines - can be left to the
primitive carousal of a CD4 protein inhibitor by name nef so named by the
company that identified the proteins which HIV DNA based do not produce, it may
not escape our mind that the intrepid connection between the SV…..In one
Deusberg’s exertion’s “AIDS is not a disease. Instead, the AIDS Syndrome is a
steadily growing collection of (currently) about thirty “previously known”
(old) diseases.
Surprisingly in view of their notoriety for AIDS
definitions, It is true, however, that
the incidence of AIDS diseases has increased dramatically in the 1980’s as
intravenous drug use has increased and as both the consumption of recreational
drugs used as sexual stimulants and the use of AZT as antiviral drug have
increased in male homosexuals….”, may true to a large possible extent, that the
problem of HIV viruses, as they apply to Deusberg theories, is not necessarily
the lipid bi-layer of its outer shell which duck the human cells containing
CCR5 receptor, which also promotes the second attachment between the Virus and
the ducking CCR5 from the HIV virus.
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